Macrophage Therapy For Acute Liver Injury (MAIL)

The aim of this trial is to test the safety and tolerability of macrophage cell therapy in acute liver injury following paracetamol overdose.

Macrophage Therapy For Acute Liver Injury (MAIL) Trial: A Phase 1 Randomised, Blinded, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages (AAM) in Patients with Paracetamol-induced Acute Liver Injury.

Chief Investigator: Professor James Dear 

Number and location of participating sites (by region/ country): Single Centre, Edinburgh Royal Infirmary

ISRCTN number: ISRCTN12637839

Funder:  Medical Research Council

Start and End date

Of grant award: 01 December 2022 - 30 November 2025

Of recruitment: 01 September 2023 - 30 April 2025

Current Status: Recruiting

Email: MAIL.Trial@ed.ac.uk

Sponsor: University of Edinburgh and NHS Lothian -  https://www.accord.scot/

Chief Investigator:

Professor James Dear, University of Edinburgh, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, james.dear@ed.ac.uk

Trial Manager:

Anna Heye, Edinburgh Clinical Trials Unit, Usher Building, The University of Edinburgh, 5‒7 Little France Road, Edinburgh BioQuarter ‒ Gate 3, Edinburgh EH16 4UX   MAIL.Trial@ed.ac.uk

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ECTU involvement: Trial Management, Statistics, Database