Edinburgh Clinical Trials


The main aim of this study is to establish if giving regular, low dose morphine capsules twice a day are better than placebo (dummy) for chronic breathlessness and whether morphine improves daily activity.

A parallel group, double-blind, randomised, placebo-controlled trial comparing the effectiveness and cost effectiveness of low dose oral modified release morphine versus placebo on patient-reported worst breathlessness in people with chronic breathlessness.


Chief Investigator: Miriam Johnston


Number and location of participating sites (by region/ country): Multiple sites across the UK


EudraCT number:  2019-002479-33


Funder: HTA

Start and End date

Of grant award                 March 2019 to August 2022

Of recruitment                  April 2020 -


Current Status: Recruitment starting April 2020


Trial Unblinding Information: In circumstances where unblinding is necessary please refer to the protocol and follow instructions provided. Contact details are provided below.


Contact details:


Hull University Teaching Hospitals NHS Trust (UK)

Professor Miriam Johnson miriam.johnson@hyms.ac.uk

Bronwen Williams 01482 462271  bronwen.williams@hyms.ac.uk

Research Nurse: N/A


ECTU involvement: Statistics and Health Economics

Maberl Trial Logo