The main aim of this study is to establish if giving regular, low dose morphine capsules twice a day are better than placebo (dummy) for chronic breathlessness and whether morphine improves daily activity.
A parallel group, double-blind, randomised, placebo-controlled trial comparing the effectiveness and cost effectiveness of low dose oral modified release morphine versus placebo on patient-reported worst breathlessness in people with chronic breathlessness.
Chief Investigator: Miriam Johnston
Number and location of participating sites (by region/ country): Multiple sites across the UK
EudraCT number: 2019-002479-33
Start and End date:
Of grant award March 2019 to August 2022
Of recruitment April 2020 -
Current Status: Recruitment starting April 2020
Trial Unblinding Information: In circumstances where unblinding is necessary please refer to the protocol and follow instructions provided. Contact details are provided below.
Hull University Teaching Hospitals NHS Trust (UK)
Professor Miriam Johnson firstname.lastname@example.org
Bronwen Williams 01482 462271 email@example.com
Research Nurse: N/A
ECTU involvement: Statistics and Health Economics