HEMOglobin transfusion threshold in Traumatic brain Injury OptimizatioN: The HEMOTION TRIAL PROTOCOL
Most trauma deaths are related to traumatic brain injury (TBI). Although the management of patients has improved, mortality remains unacceptably high, and half of survivors of moderate and severe TBI are left with major functional impairment. Current management guidelines are based on limited evidence and practice is highly variable. Most acutely ill patients with TBI will develop anemia, which may decrease oxygen delivery to a fragile brain. While clinical practice is moving towards transfusing at low hemoglobin (Hb) levels, experts have expressed concerns regarding restrictive strategies, which may adversely affect clinical outcomes in TBI. Our primary objective is to evaluate the effect of red blood cell (RBC) transfusion thresholds on neurological functional outcome. We hypothesize that a liberal transfusion strategy improves outcomes compared to a restrictive strategy.
Chief Investigator: Prof Alexis F Turgeon
Number and location of participating sites / geographical scope (by region/ country): UK 8 sites Canada multiple sites
Funder: Canadian Institutes of Health Research
Start and End date
Of grant award: December 2016 for 5 years
Current Status: Recruiting
GDPR privacy statement: GDPR statement provided at consent
Sponsor: University of Laval, Canada
CI: Professor A Turgeon, CHU de Québec-Université Laval
1401, 18e Rue, Québec (Québec) G1J 1Z4, Canada
Phone: 418-649-0252, extension 66064; Email: Alexis.Turgeon@fmed.ulaval.ca
Trial manager: Lucy Clayton; +1 (514) 345-4931 ext 6816; Lucy.email@example.com
For UK enquiries contact UK.Hemotion@ed.ac.uk
ECTU Involvement: UK Co-ordination and blinded 6 month follow up of UK cohort.