Edinburgh Clinical Trials

ABC Sepsis

Feasibility of 5% Albumin compared with Balanced Crystalloid, as intravenous fluid resuscitation in adult patients with sepsis, presenting as an emergency to hospital

The aim of this research study is to compare two different fluids (Human Albumin Solution (HAS) and Balanced Crystalloid that are given via a drip to patients with severe infection (sepsis). We plan to see which fluid is better, and to see if they have a role in improving a patient’s recovery time, reducing complications and the length of time they stay in hospital. This study plans to find out if one fluid is better overall than the other before completing a larger research study.


Chief Investigator: Prof Alasdair Gray  

ABC Sepsis

Number and location of participating sites (by region/ country):

15 UK Sites

EudraCT number: 2020-01352-18

ISRCTN number:  NCT04540094

Funder: J P Moulton Charitable Foundation

Start and End date

Of grant award: 01 Jul 2020 - 30 Apr 2023

Of recruitment: 06 June 2021 = 08 June 2022



Current Status: Closed

Trial Website: No

Email: abcsepsis.trial@ed.ac.uk


UK GDPR Privacy Statement: TBC


Sponsor: ACCORD (https://www.accord.ed.ac.uk/)

Chief Investigator:

Prof Alasdair Gray Address:    Emergency Medicine Research Group (EMERGE) Department of Emergency Medicine Royal Infirmary of Edinburgh 51 Little France Crescent Edinburgh, EH16 4SA

Email: Alasdair.gray@ed.ac.uk


Trial Manager: Kat Oatey Email: abcsepsis.trial@ed.ac.uk


Research nurse: Julia Grahamslaw Email: Julia.grahamslaw@nhslothian.scot.nhs.uk


Protocol https://doi.org/10.1177/1751143722110369


Statistical Analysis Plan dx.doi.org/10.17504/protocols.io.14egn276mg5d/v1


ECTU involvement: Trial management / Statistics / Health Economics / Data base