EAVE II
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Our Publications

See our findings in academic paper publications.

Quick Access List

A reference list of our key academic paper publications

BNT162b2 COVID-19 vaccination uptake, safety, effectiveness and waning in children and young people aged 12–17 years in Scotland

September 2022: Research published in The Lancet Regional Health Europe looks at the uptake, safety, and effectiveness over time of the Pfizer-BioNTech COVID-19 vaccine for people aged 12-17 in Scotland.

Characterising adults in Scotland who are not vaccinated against COVID-19

September 2022: A Research Letter published in The Lancet looks at who has not yet been vaccinated for COVID-19 in Scotland.

Second-dose Oxford-AstraZeneca and Pfizer-BioNTech vaccines and blood clotting and bleeding events in Scotland

August 2022: Research published in Nature Communications looks at potential side effects of second dose COVID-19 vaccines, related to bleeding and blood clotting.

Effectiveness of Two-Dose Pfizer-BioNTech vaccine among Adolescents in Scotland and Brazil

August 2022: New paper looks at how the effectiveness of two-doses of the Pfizer-BioNTech vaccine changes over time in adolescents. The paper looks at the effectiveness of protection provided against symptomatic infection of the SARS-CoV-2 virus and severe cases of COVID-19.

Pre-print: Obesity is associated with reduced SARS-CoV-2 vaccine efficacy

June 2022: New pre-print outlines research done in collaboration with and led by the University of Cambridge. This study looks at the relationship between the efficacy of COVID-19 vaccines and obesity.

Protocol: Common protocol for validation of the QCOVID algorithm across the four UK nations

June 2022: New protocol outlining a common procedure for conducting and reporting on validation exercises for the QCOVID algorithm.

Impact of first UK COVID-19 lockdown on hospital admissions in England, Scotland and Wales

May 2022: Research published in eClinical Medicine looks at how the first wave of the COVID-19 pandemic has disrupted healthcare in England, Scotland and Wales.

Impact on emergency and elective hospital-based care in Scotland over the first year of the pandemic

May 2022: Research published in the Journal of the Royal Society of Medicine looks at how the COVID-19 pandemic disrupted healthcare in Scotland from March 2020 to March 2021.

Severity of omicron variant of concern and effectiveness of vaccine boosters against symptomatic disease in Scotland (EAVE II)

April 2022: Research published in The Lancet Infectious Diseases looks at COVID-19 hospital admissions, and the effectiveness of vaccine boosters, in people infected by the Omicron variant in Scotland.

Pre-print: Waning of BNT162b2 or ChadOx1 mRNA Boosters against symptomatic infection and severe COVID-19 in Brazil and Scotland

April 2022: Pre-print article published on preprints with The Lancet investigates the waning effectiveness of booster vaccines from Pfizer BioNTech (BNT162b2) and Oxfrord-AstraZeneca (ChadOx1), against symptomatic infection and severe COVID-19 in Brazil and Scotland.

Vaccine Effectiveness of Two-Dose BNT162b2 Over Time Against COVID-19 Symptomatic Infection and Severe Cases Among Adolescents

April 2022 (Pre-print): Research published in The Lancet looks at the effectiveness of two COVID-19 vaccine doses in adolescents over time.

BNT162b2 and ChAdOx1 nCoV-19 Vaccinations, Incidence of SARS-CoV-2 Infections and COVID-19 Hospitalisations in Scotland in the Delta era

March 2022: Research published in the Journal of Global Health looks at patterns of COVID-19 disease and hospital admissions in Scotland when the Delta variant was most common.

Uptake of infant and preschool immunisations in Scotland and England during the COVID-19 pandemic

February 2022: Research published in PLOS Medicine looks at the uptake of routine childhood vaccines in Scotland and England before, during and after COVID-19 pandemic restrictions.

First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis

First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales.

Protocol: Investigating the uptake, effectiveness and safety of COVID-19 vaccines

February 2022: Protocol outlining a new study aimed at assessing the uptake rates, effectiveness, and safety of all currently approved COVID-19 vaccines in the UK.

Risk of serious COVID-19 outcomes among adults with asthma in Scotland: a national incident cohort study

January 2022: Research published in The Lancet Respiratory Medicine looks at which adults with asthma in Scotland might be at risk of serious complications from COVID-19.

SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland

January 2022: Research published in Nature Medicine looks at COVID-19 disease and vaccination in pregnant women in Scotland, and the impact this has had on their health.

Uptake, effectiveness and safety of COVID-19 vaccines in children and young people in Scotland: Protocol for early pandemic evaluation and enhanced surveillance of COVID-19 (EAVE II)

Protocol for a prospective study to investigate the uptake, effectiveness and safety of COVID-19 vaccines in children and young people (CYP) aged 0 to 17 years in Scotland.

Two-dose ChAdOx1 nCoV-19 vaccine protection against COVID-19 hospital admissions and deaths over time

December 2021: The protection offered by the Oxford-Astra Zeneca Covid-19 vaccine declines after three months of receiving two doses, a study says.

Risk of COVID-19 hospital admission among children aged 5–17 years with asthma in Scotland: a national incident cohort study

November 2021: Research published in The Lancet Respiratory Medicine looks at the risk of children with asthma in Scotland being admitted to hospital with COVID-19.

Retrospective cohort study to evaluate medication use in patients hospitalised with COVID-19 in Scotland: protocol for a national observational study

Protocol for an exploratory drug utilisation study, aimed at providing in-depth descriptions of patients receiving any combination of three therapeutic drugs (dexamethasone, remdesivir and tocilizumab), as well as the treatment patterns observed in Scotland.

Characteristics and risk of COVID-19-related death in fully vaccinated people in Scotland

October 2021: A research letter published in The Lancet looks at people in Scotland who have died of COVID-19 after two vaccine doses, and what the risks and causes might be.

Neurological complications after first dose of COVID-19 vaccination and SARS-CoV-2 infection

October 2021: Vaccine data analysis from England and Scotland, published in the Nature Medicine, looks at possible links between conditions of the nervous system and COVID-19 infection and vaccination.

Association between multimorbidity and mortality in a cohort of patients admitted to hospital with COVID-19 in Scotland

October 2021: Research published in the Journal of the Royal Society of Medicine looks at the risk of death after being admitted to hospital with COVID-19. We look at patients who were shielding or living with multiple long term conditions, during the first wave of the pandemic in Scotland.

Vaccine Efficacy against the Delta Variant in Scotland

October 2021: Research published in the New England Journal of Medicine estimates the level of protection that vaccines give against deaths from COVID-19 infection with the Delta variant.

COVID-19 hospital admissions and deaths post BNT162b2 and ChAdOx1 vaccinations: National prospective cohort study of 2.57 million people in Scotland

September 2021: New research published in The Lancet Respiratory Medicine looks at the number of people in Scotland who have died from or been admitted to hospital with COVID-19 after at least one vaccine dose.

Predicted COVID-19 positive cases, hospitalisations, and deaths associated with the Delta variant of concern, June–July, 2021 (EURO 2020)

July 2021: A research letter in The Lancet Digital Health models the impact of the Delta variant on COVID-19 cases, hospital admissions and deaths in Scotland around the time of EURO 2020.

Temporal trends and forecasting of COVID-19 hospitalisations and deaths in Scotland using a national real-time patient-level data platform: a statistical modelling study

July 2021: A paper published in The Lancet Digital Health describes the EAVE II cohort and its use to monitor and forecast COVID-19 health outcomes across the Scottish population since March 2020.

SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness

June 2021: The Delta variant of COVID-19 is associated with approximately double the risk of hospitalisation compared with the Alpha variant, but vaccine continues to protect.

First-dose ChAdOx1 and BNT162b2 COVID-19 vaccines and thrombocytopenic, thromboembolic and hemorrhagic events in Scotland.

June 2021: EAVE II study of 2.53 million first COVID-19 vaccine doses across Scotland shows small increases in risk for some adverse events following Oxford-AstraZeneca vaccine.

Cohort profile: Early pandemic evaluation and enhanced surveillance of COVID-19 (EAVE II) database

The EAVE II cohort profile, detailing why the cohort was set up, who is in the cohort, and what has been found, measured, and more.

Impact of COVID-19 Lockdown on the Incidence and Mortality of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: National Interrupted Time Series Analyses for Scotland and Wales

May 2021: First national level analysis shows hospital admissions for COPD (Chronic Obstructive Pulmonary Disease) across Scotland and Wales fell during the first COVID-19 lockdown.

Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland

May 2021: A milestone study, which points to the success of first dose mass vaccination in reducing COVID-19 hospitalisations across Scotland, is now available from The Lancet.

Impact of COVID-19 lockdown on emergency asthma admissions and deaths: national interrupted time series analyses for Scotland and Wales

March 2021: Study finds 36% fewer people were admitted to hospital in Scotland and Wales in the first lockdown due to asthma.

Pre-print of COVID-19 Vaccines Effectiveness in Scotland paper

Vaccination has been linked to a substantial reduction in the risk of Covid-19 admissions to Scotland’s hospitals, landmark research suggests in pre-print.

Living risk prediction algorithm (QCOVID) for risk of hospital admission and mortality from COVID-19 in adults: national derivation and validation cohort study

October 2020: A study to derive and validate a risk prediction algorithm to estimate hospital admission and mortality outcomes from COVID-19 in adults.

Impact of COVID-19 on accident and emergency attendances and admissions in Scotland

October 2020: A study published in the Journal of the Royal Society of Medicine highlights significant drops in A&E attendances, and emergency and planned hospital admissions across Scotland during the first few months of the pandemic.

Protocol: EAVE II Study

Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II): Protocol for an Observational Study using Linked Scottish National Data