Project: PUFFIN
Poly-unsaturated fats for improving nasal polyps and asthma (PUFFIN)
The efficacy and mechanisms of action of N-3 poly-unsaturated fatty acid supplementation in people with non-steroidal exacerbated airways disease and uncontrolled asthma.
Project overview
The project aims to work out if patients who have a particular type of asthma (non-steroidal exacerbated airways disease (N-ERD) and symptomatic asthma) will have greater improvement in controlling their asthma (measured by the ACQ-6 test) 24 weeks after starting the study when treated with omega-3 fatty acids (n-3 polyunsaturated fatty acids (PUFA)) compared to participants treated with placebo.
The study is an interventional clinical trial of an investigational medicinal product (drug). It is a phase III, randomised, placebo-controlled, two arm, double-blind, multicentre clinical trial in 98 participants with non-steroidal exacerbated airways disease (N-ERD) and asthma.
Outcomes will be assessed primarily measuring the change in asthma control using the ACQ-6 test between baseline and 24 weeks post-randomisation. A subgroup of 52 participants (26 per group) will be recruited into the sub-study looking to test markers of inflammation and how they change from the beginning to the end of the study.
Key People
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Andrew Wilson |
Anne-Marie Minihane |
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| Clinical Senior Lecturer in Respiratory Health | Professor of Nutrigenetic | ||
| Based at: University of East Anglia | Based at: University of East Anglia | ||
| Andrew's Profile | Anne-Marie's Profile | ||
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Ann Marie Swart |
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Allan Clark |
| Clinical Trials Unit Director | Medical Statistician | ||
| Based at: University of East Anglia | Based at: University of East Anglia | ||
| Ann Marie's Profile | Allan's Profile | ||
Glenis Scadding |
Peter Howarth |
Shuaib Nasser |
Philip Calder |
| Consultant Physician | Professor of Allergy and Respiratory Medicine | Consultant Physician | Professor of Nutritional Immunology |
| Based at: Royal National Ear, Nose and Throat Hospital | Based at: University of Southampton | Based at: Addenbrooke's Hospital | Based at: University of Southampton |
| Glenis' Profile | Peter's Profile | Philip's Profile | |
Juliet High |
Colin McAlister |
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| Senior Trial Manager |
Trial Manager |
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| Based at: University of East Anglia | Based at: University of East Anglia | ||
| Juliet's Profile |
Timeline
April 2021 - April 2024
Contact us
Want to know more? Contact details below.
Professor Andrew Wilson | Chief Investigator
Colin McAlister | Trial Manager
Acknowledgements
Funder: National Institute for Health Research Efficacy and Mechanism Evaluation (NIHR EME)
Investigational Medicinal Product (IMP) supplier: BASF