Asthma UK Centre for Applied Research

Project: PUFFIN

Poly-unsaturated fats for improving nasal polyps and asthma (PUFFIN)

The efficacy and mechanisms of action of N-3 poly-unsaturated fatty acid supplementation in people with non-steroidal exacerbated airways disease and uncontrolled asthma.

Project overview

The project aims to work out if patients who have a particular type of asthma (non-steroidal exacerbated airways disease (N-ERD) and symptomatic asthma) will have greater improvement in controlling their asthma (measured by the ACQ-6 test) 24 weeks after starting the study when treated with omega-3 fatty acids (n-3 polyunsaturated fatty acids (PUFA)) compared to participants treated with placebo.

The study is an interventional clinical trial of an investigational medicinal product (drug).  It is a phase III, randomised, placebo-controlled, two arm, double-blind, multicentre clinical trial in 98 participants with non-steroidal exacerbated airways disease (N-ERD) and asthma.

Outcomes will be assessed primarily measuring the change in asthma control using the ACQ-6 test between baseline and 24 weeks post-randomisation. A subgroup of 52 participants (26 per group) will be recruited into the sub-study looking to test markers of inflammation and how they change from the beginning to the end of the study.

Key People 

Headshot of Andrew Wilson

Andrew Wilson


Anne-Marie Minihane

Clinical Senior Lecturer in Respiratory Health Professor of Nutrigenetic
Based at: University of East Anglia Based at: University of East Anglia
Andrew's Profile Anne-Marie's Profile
Ann Marie Swart

Ann Marie Swart

Allan Clark

Allan Clark

Clinical Trials Unit Director Medical Statistician
Based at: University of East Anglia Based at: University of East Anglia
Ann Marie's Profile Allan's Profile

Glenis Scadding

Peter Howarth

Shuaib Nasser

Philip Calder

Consultant Physician Professor of Allergy and Respiratory Medicine Consultant Physician Professor of Nutritional Immunology
Based at: Royal National Ear, Nose and Throat Hospital Based at: University of Southampton Based at: Addenbrooke's Hospital Based at: University of Southampton
Glenis' Profile Peter's Profile   Philip's Profile

Juliet High

Colin McAlister

Senior Trial Manager

Trial Manager

Based at: University of East Anglia Based at: University of East Anglia
Juliet's Profile  


April 2021 - April 2024

Contact us

Want to know more? Contact details below.

Professor Andrew Wilson | Chief Investigator

Colin McAlister | Trial Manager

Norwich Clinical Trials Unit


Funder: National Institute for Health Research Efficacy and Mechanism Evaluation (NIHR EME)

Investigational Medicinal Product (IMP) supplier: BASF