Project: BREATHE4T

Breathing Retraining for Asthma Trial of Home Exercises for Teenagers (BREATHE4T); repurposing, refining and feasibility

This multi-disciplinary programme of work is aiming to find out if we can repurpose the effective, adult BREATHE breathing retraining intervention to create an age-appropriate intervention for young people with asthma and to demonstrate acceptability and feasibility in this population.

Young people with asthma have impaired quality of life despite using appropriate medication. Many experience dysfunctional breathing. Our DVD delivered breathing retraining programme (BREATHE) improved quality of life in adult asthma but there is no robust evidence for the value of breathing retraining in younger patients. Our recent work with this age group would suggest that the adult intervention would need to be redesigned to be appropriate for, and acceptable to, young people.

Specific objectives

1. To use theory-, evidence- and person-based behavioural analysis to identify the key, young person specific, behavioural issues, needs and challenges that the intervention must address (Stage 1).

2. To develop and optimise the intervention (Stage 2).

3. To undertake a feasibility trial assessing acceptability and feasibility of the intervention (Stage 3).

We're recruiting young people (12-17 years) with physician-diagnosed asthma and impaired quality of life, mostly from primary care and hospital clinics using the CRN network. We're working in collaboration with AsthmaUK, who will provide publicity and an additional recruitment route.

Intervention

A self-guided, breathing retraining digital intervention, delivered via a mobile-friendly, online platform.

Repurposing, optimisation, acceptability, feasibility

We will follow a theory-, evidence- and person-based approach:

Stage 1: intervention planning: Conduct a behavioural analysis to identify key, adolescent specific, behavioural issues, needs and challenges that the intervention must address, drawing on literature, qualitative interviews and consultation with study Patient and Public Involvement (PPI) panels.
Stage 2: intervention development: Development of intervention components, with active involvement of PPI panels and optimisation using feedback from qualitative interviews to ensure the intervention is acceptable and engaging.

Stage 3: feasibility trial: Trialling of breathing retraining intervention in real-life context to evaluate acceptability and feasibility in practice. A total of 116 young people with asthma will be randomised to the intervention or control and reassessed after 6 months. Key objectives are to assess acceptability, uptake, success in collecting follow up data and variance in asthma-related outcome measures.

BREATHE4T project

Get Involved

Are you, or do you know anyone who is, 12-17 years old and living with asthma?

Help the BREATHE4T team find out if a new website can help teenagers manage their asthma better and improve their overall lives!

BREATHE4T study recruitment website

Key People

	Graham Roberts		Stephanie Easton
	Chief Investigator and Consultant Paediatrician		Trial Co-ordinator and PhD student
	Based at: University Hospital Southampton		Based at: University Hospital Southampton
	Graham's Profile		Stephanie's PhD Profile
	Ben Ainsworth		Mike Thomas
	Digital Intervention Development Lead		Primary Care Lead
	Based at: University of Bath		Based at: University of Southampton
	Ben's Profile		Mike's Profile
	Erika Kennington		Rebecca Knibb
	Asthma UK and British Lung Foundation Partnership Lead		Expert in Behaviour Change
			Based at: University of Aston
			Rebecca's Profile
	Sue Latter		Amy Whitehead
	Qualitative Lead		Statistics Lead
	Based at: University of Southampton		Based at: Southampton Clinical Trials Unit
	Sue's Profile		Amy's Profile
	Denise Gibson		Mike Bahrami-Hessari
	Physiotherapy Lead		Patient and Public Involvement Lead
	Based at: University Hospital Southampton		Based at: University Hospital Southampton
	Amber Cook
	Research Nurse
	Based at: University Hospital Southampton