Adam Peel

Project: The utility of biomarkers in the management of acute asthma: a feasibility study

Existing ways of assessing asthma (such as peak flow meters) tell us about lung function and how well people are breathing but they don’t actually tell us how inflamed their airways are nor what the most appropriate treatment is. Every time a person exhales, they breathe out water vapour and various gases; dissolved in the water vapour are different substances that come from the lining of the airways. We hope that by capturing and examining these compounds during an asthma attack we can discover which ones provide the most reliable and useful information for guiding treatment and managing patients. There is a growing body of research in this field; this PhD study aims to determine the feasibility of such a study in the acute hospital setting.

About me

My research interests lie in the management of chronic disease; from issues around therapy adherence to the use of technology to guide treatment and management. My current focus is on breathomics – the analysis of volatile organic compounds in exhaled breath – for biomarker discovery, diagnosis and disease management. I hold undergraduate degrees in Social Sciences, Osteopathy and Nursing, and am a registered nurse practicing at the Norfolk & Norwich University Hospital.

Publications

• Alahmadi F, Peel A, Keevil B, Niven R, Fowler SJ. Assessment of adherence to corticosteroids in asthma by drug monitoring or fractional exhaled nitric oxide: A literature review. Clin Exp Allergy. 2021 Jan;51(1):49-62. DOI: 10.1111/cea.13787

• Peel AM, Wilkinson M, Sinha A, Loke YK, Fowler SJ, Wilson AM. Volatile organic compounds associated with diagnosis and disease characteristics in asthma–A systematic review. Respiratory Medicine. 2020 May 16:105984. DOI: 10.1016/j.rmed.2020.105984 

• Terrington DL, Hayton C, Peel A, Fowler SJ, Fraser W, Wilson AM. The role of measuring exhaled breath biomarkers in sarcoidosis: a systematic review. Journal of breath research. 2019 Jun 24;13(3):036015. DOI: 10.1088/1752-7163/ab1284

• Mattishent, K. Thavarajah, M. Sinha, A. Peel, A. Egger, M. Solomkin, J. de Jonge, S. Latif, A. Berenholtz, S. Allegranzi, B. Loke, YK. (2018) Evaluation of the safety of 80% fraction of inspired oxygen compared to 30-35% fraction of inspired oxygen in patients undergoing surgery: a systematic review and meta-analysis. Accepted for publication; British Journal of Anaesthesia 
• Peel, AM. Loke, YK. Wilson, AM. (2018) Asthma Breathomics and Biomedium Consideration (letter to Editor). Chest
• Peel, AM. Loke, YK. Wilson, AM. (2018) Asthma Breathomics – Promising Biomarkers in Need of Validation (letter to Editor). Pediatric Pulmonology, 2018; 1-3. DOI: 10.1002/ppul.23941
• Peel, AM. Loke, YK. Wilson, AM. (2017) Asthma Breathomics: A Systematic Review Protocol. PROSPERO CRD42017082727 http://www.crd.york.ac.uk/PROSPERO/display_record.php?ID=CRD42017082727
• Crossman-Barnes, CJ. Peel, AM. Fong Soe Khioe, R. Sach, T. Wilson, AM. Barton, G. (2017) Economic Evidence for Non-pharmacological Asthma Management Interventions: A Systematic Review. Allergy, European Journal of Allergy & Clinical Immunology.DOI: 10.1111/all.13337
• Forsyth, A. Peel, AM. Wilson, AM. (2017) Procalcitonin and C-Reactive protein as biomarkers for the initiation of antibiotic therapy in adult patients with acute asthma exacerbations: a systematic review and meta-analysis protocol. PROSPERO: International Prospective Register of Systematic Reviews. CRD42017074575 http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42017074575
• Peel, AM. Crossman-Barnes, CJ. Tang, J. Fowler, SJ. Davies, GA. Wilson, AM. Loke, YK (2017) Biomarkers in Adult Asthma: a Systematic Review of 8-Isoprostane in Exhaled Breath Condensate J. Breath Res.https://doi.org/10.1088/1752-7163/aa5a8a
• Peel, A. Thorpe, G. Deane, K. (2015) Factors Associated with Non-Adherence to Oral Medication for Inflammatory Bowel Disease: A Systematic Review of the Literature 1980-2013. Gastrointestinal Nursing 13(9):17-24 · November 2015. DOI: http://dx.doi.org/10.12968/gasn.2015.13.9.17

Research activity (conferences, congress, annual scientific meeting)

• Terrington, D. Hayton, C. Fowler, S. Wilson, A. (2018) Exhaled Breath Biomarkers in Sarcoidosis: A Systematic Review. European Respiratory Society Conference (poster presentation).
• Peel, A. (2017) Joint Centre meeting with the MRC & Asthma UK Centre in Allergic Mechanisms of Asthma - a PhD perspective. Weblog; Asthma UK Centre for Applied research.www.aukcar.ac.uk/article/joint-centre-meeting-mrc-asthma-uk-centre-allergic-mechanisms-asthma-phd-perspective
• Peel, AM. Fowler, SJ. Davies, GA. Wilson, AM. Loke, YK (2017) Asthma Bronchial Challenge: A Study in Breathomics. Poster presentation. AUKCAR MRC Asthma UK Joint Centre Event 20/09/2017 & AUKCAR Annual Scientific Meeting 23/01/2018
• Peel, AM. Crossman-Barnes, CJ. Tang, J. Fowler, SJ. Davies, GA. Wilson, AM. Loke, YK (2016) Biomarkers in Adult Asthma: A Systematic Review of 8-Isoprostane in Exhaled Breath Condensate. British Thoracic Society Winter Meeting, Oral Presentation. 7/12/2016
• Peel, AM. Crossman-Barnes, CJ. Tang, J. Fowler, SJ. Davies, GA. Wilson, AM. Loke, YK (2016) 8-isoprostane in Exhaled Breath Condensate: A Systematic Review in Adult Asthma. Asthma UK Annual Scientific Meeting, Oral Presentation. 9/11/2016
• Christina-Jane Crossman-Barnes, Adam Peel, Rebekah Fong-Soe-Khioe, Tracey Sach, Andrew Wilson, Garry Barton (2016) Economic evidence for non-pharmacological asthma management interventions: Systematic Review. Asthma UK Annual Scientific Meeting, Poster Presentation. 9/11/2016
• Peel, A. Fowler, S. Davies, G. Loke Y. Wilson, A. (2016) Biomarkers in the Management of Acute Asthma: A Feasibility Study. UEA Faculty of Medicine & Health Sciences Student Conference, Poster Presentation. 03/03/2016 

Acknowledgements

Funded by Asthma UK