Advanced Care Research Centre

ACRC Journal Articles

Papers which ACRC has written or contributed to are featured below.

In order to make our research more accessible, we are in the process of developing lay summaries for papers we have published. These are available, here.

Entity linking for English and other languages: a survey

Guellil, I., Garcia-Dominguez, A., Lewis, P.R. et al. Knowledge and Information Systems (2024).

A mixed-methods evaluation of patients’ views on primary care multi-disciplinary teams in Scotland

Sweeney, K, Donaghy, E, Henderson, D, Wang, HHX, Thompson, A, Guthrie, B & Mercer, SW 2024, British Journal of General Practice Open (BJGP Open).

Storylines of family medicine VIII: clinical approaches

Ventres, W, Stone, L, Gibson-Oliver, L, Meehan, E, Ricker, M, Loxterkamp, D, Ogbeide, S, deGruy, F, Mahoney, M, Lin, S, MacRae, C & Mercer, SW 2024, Family Medicine and Community Health, vol. 12, no. Suppl 3, e002795.

Multiple adverse outcomes associated with antipsychotic use in people with dementia: a population-based cohort study

Mok, PLH, Carr, MJ, Guthrie, B, Morales, DR, Sheikh, A, Elliott, RA, Camacho, EM, Staa, TV, Avery, AJ & Ashcroft, DM 2024, British Medical Journal (BMJ), vol. 385, e076268.

Storylines of family medicine V: honing the therapeutic self

Mercer, SW 2024, Family Medicine and Community Health.

Tackling the inverse care law in Scottish general practice: A report funded by the Health Foundation and produced by the University of Glasgow and the University of Edinburgh

Blane, D, Lunan, C, Bogie, J, Albanese, A, Henderson, D & Mercer, SW, University of Glasgow & University Edinburgh. Health Foundation

Primary care transformation in Scotland: a qualitative evaluation of the views of patient

Eddie Donaghy, Kieran Sweeney, David Henderson, Colin Angus, Morag Cullen, Mary Hemphill, Harry HX Wang, Bruce Guthrie and Stewart W Mercer, British Journal of General Practice, 13 May 2024; BJGP.2023.0437. DOI:

Predicting short- to medium-term care home admission risk in older adults: a systematic review of externally validated models

Leonard Ho, Carys Pugh, Sohan Seth, Stella Arakelyan, Nazir I Lone, Marcus J Lyall, Atul Anand, Jacques D Fleuriot, Paola Galdi, Bruce Guthrie Age and Ageing, Volume 53, Issue 5, May 2024, afae088,

Multimorbidity analysis with low condition counts: a robust Bayesian approach for small but important subgroups

Guillermo Romero Moreno a, Valerio Restocchi a, Jacques D. Fleuriot a, Atul Anand b, Stewart W. Mercer c, Bruce Guthrie, eBioMedicine, Volume 102, April 2024, 105081

Analysis of the impact of COVID-19 on Scotland’s care-homes from March 2020 to October 2021: national linked data cohort analysis

Jennifer Kirsty Burton, Megan McMinn, James E Vaughan, Glenna Nightingale, Jacques Fleuriot, Bruce Guthrie, Age and Ageing, Volume 53 Issue 2, February 2024, afae015,

Income Trajectories and Precarity in Later life

Alan Marshall, Chima Eke, Bruce Guthrie, Carys Pugh, Sohan Seth, Journal of Population Ageing, January 2024,

Barriers and Opportunities for WHO ‘Best Buys’ Non-Communicable Disease Policy Adoption and Implementation From a Political Economy Perspective: A Complexity Systematic Review.

Giulia Loffreda, Stella Arakelyan, Ibrahim Bou-Orm, Hampus Holmer, Luke N. Allen, Sophie Witter, Alastair Ager, Karin Diaconu. 2024. International Journal of Health Policy and ManagementDOI: 10.34172/IJHPM.2023.7989.

Comparing Research Priority-Setting Partnerships for Older Adults Across International Health Care Systems: A Systematic Review

Leonard Ho, Katherine Lloyd, Martin Taylor-Rowan, Shoba Dawson, Monica Logan, Stephanie Leitch, Terence J. Quinn, Susan D. Shenkin, Steve W. Parry, Heather Jarman, Emily J. Henderson, Journal of Post Acute and Long Term Care Medicine VOLUME 24, ISSUE 11, P1726-1745, NOVEMBER 2023

The Effectiveness of Advance Care Planning (ACP) Training for Care Home Staff: An Updated Systematic Review

Victoria Barber-Fleming, Mala Mann, Gillian Mead, Aoife Gleeson, Journal of Long Term CareYear: 2023, Page/Article: 273–287, 

Being there’ is what matters: Methodological and ethical challenges when undertaking research on the outdoor environment with older people during and beyond the COVID-19 pandemic

Effectiveness of holistic assessment-based interventions for adults with multiple long-term conditions and/or frailty: An umbrella review of systematic reviews

Stella Arakelyan, Nataysia Mikula-Noble, Leonard Ho, Nazir Lone, Atul Anand, PhD, Marcus J Lyall, Prof Stewart W Mercer, Prof Bruce Guthrie, The Lancet Healthy Longevity, Volume 4 Issue 11, E629-E644 Nov 23 

The United Nations Convention on the Rights of Persons with Disabilities and Social Work: Evidence for Impact?

Pearse McCusker, Lauren Gillespie, Gavin Davidson, Sarah Vicary, Kevin Stone, Environmental Research and Public Health, 2023, 20(20), 6927 

Evaluation of the Implementation of Street Support Edinburgh in Response to the Predicted Increase in Homelessness in Edinburgh Following the COVID-19 Pandemic

Fiona Cuthill, Kieran Turner, Maria Wolters, Aba-Sah Dadzie, Emily Adams, Stewart Mercer International Journal on Homelessness, 2023 3(3), 1–15. 

Supported decision making

Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline

Rodrigo Ramalho, Paolo Fusar Poli, Andreas S. Lappas, Daniel Pinto, Kristian Steen Frederiksen, Grazia Maria Corbi, Olga Karpenko, Jean Georges, João Durães,  Mathias Schlögl, Ozlem Yilmaz, Cornel Sieber, Susan D. Shenkin, Lee Smith, Jean Yves Reginster, Stefania Maggi, Federica Limongi, Joan Ars, Mario Barbagallo, Antonio Cherubini, Terry Quinn  European Geriatric Medicine

Understanding performance and reliability of NLP tools: A comparison of four NLP tools predicting stroke phenotypes in radiology reports

Arlene Casey Emma Davidson, Claire Grover, Richard Tobin, Andreas Grivas Huayu Zhang, Patrick Schrempf, Alison Q. O’Neil Liam Lee, Michael Walsh, Frey Pellie Karen Ferguson, Vera Cvero, Honghan Wu, Heather Whalley, Grant Mair William Whiteley, Beatrice Alex Frontiers Volume 5 - 2023

Evaluating primary care transformation: synthesis of findings across UK pilot projects. 

Emilie McSwiggan, Lauren Ng, Eddie Donaghy, Huayi Huang, John Gillies, David AG Henderson, Andrew Thompson, Harry HX Wang and Stewart W Mercer BJGP Open 2023; 7 (2): BJGPO.2022.0154. DOI:

Is polypharmacy associated with difficulty taking medicines in people aged ≥85 living at home? Findings from the Newcastle 85+ Study

Impact of data source choice on multimorbidity measurement: a comparison study of 2.3 million individuals in the Welsh National Health Service

Clare MacRae, Daniel Morales, Stewart W. Mercer, Nazir Lone, Andrew Lawson, Emily Jefferson, David McAllister, Marjan van den Akker, Alan Marshall, Sohan Seth, Anna Rawlings, Jane Lyons, Ronan A. Lyons, Amy Mizen, Eleojo Abubakar, Chris Dibben & Bruce Guthrie BMC Geriatrics 21, Article number: 309 (2023) DOI: 10.1186/s12916-023-02970-z

Examining the social networks of older adults receiving informal or formal care: a systematic review

Iris Szu-Szu Ho, Kris McGill, Stephen Malden, Cara Wilson, Caroline Pearce, Eileen Kaner, John Vines, Navneet Aujla, Sue Lewis, Valerio Restocchi, Alan Marshall & Bruce Guthrie, BMC Geriatrics 23, Article number: 531 (2023) DOI: 10.1186/s12877-023-04190-9

Complex interventions for improving independent living and quality of life amongst community-dwelling older adults: a systematic review and meta-analysis

Leonard Ho, Stephen Malden, Kris McGill, Michal Shimonovich, Helen Frost, Navneet Aujla, Iris S-S Ho, Susan D Shenkin, Barbara Hanratty, Stewart W Mercer, Bruce Guthrie, Age and Ageing, Volume 52, Issue 7, July 2023 Read more, here.

Green social prescribing: challenges and opportunities to implementation in deprived areas

Helen Frost, Tricia Tooman, Katie Hawkins, Navneet Aujla and Stewart W Mercer, British Journal of General Practice 2023; 73 (733): 342-343. DOI:

Effect on life expectancy of temporal sequence in a multimorbidity cluster of psychosis, diabetes, and congestive heart failure among 1·7 million individuals in Wales with 20-year follow-up: a retrospective cohort study using linked data

Rhiannon K Owen PhDJane Lyons MScAshley Akbari MScProf Bruce Guthrie PhD, Utkarsh Agrawal PhDProf Daniel C Alexander PhDAmaya Azcoaga-Lorenzo PhD Prof Anthony J Brookes PhD, Prof Spiros Denaxas PhDProf Carol Dezateux MDAdeniyi Francis Fagbamigbe PhDGill Harper PhDPaul D W Kirk PhDEda Bilici Özyiğit PhDProf Sylvia Richardson PhDProf Sophie Staniszewska DPhilProf Colin McCowan PhDProf Ronan A Lyons MD Prof Keith R Abrams PhD  The Lancet Public Health Volume 8, Issue 7, July 2023, Pages e535-e545

A systematic review of studies reporting on neuropsychological and functional domains used for assessment of recovery from delirium in acute hospital patients

Haruno McCartney , Erin Noble , Alasdair M J MacLullich , Daniel H J Davis , Jonathan Evans,  Susan D Shenkin, Graciela Muniz-Terrera, Daisy Sandeman, Zoë Tieges, Int J Geriatr Psychiatry. 2023 Jun;38(6):e5943. doi: 10.1002/gps.5943PMID: 37294207 Review.

Ontology-driven and weakly supervised rare disease identification from clinical notes

Hang Dong , Víctor Suárez-Paniagua , Huayu Zhang , Minhong Wang , Arlene Casey , Emma Davidson , Jiaoyan Chen,  Beatrice Alex , William Whiteley , Honghan Wu, BMC Medical Informed Decision Making. 2023 May 5;23(1):86  doi: 10.1186/s12911-023-02181-9

External validation of the QLifetime cardiovascular risk prediction tool: population cohort study

Shona Livingstone, Daniel R. Morales, Jacques Fleuriot, Peter T. Donnan & Bruce Guthrie, BMC Cardiovascular Disorders, volume 23, Article number: 194 (2023), Available here.


Søren T Skou, Frances S Mair, Martin Fortin, Bruce Guthrie, Bruno P Nunes, J Jaime Miranda, Cynthia M Boyd, Sanghamitra Pati, Sally Mtenga, Susan M Smith, Nature Review Disease Primers2022 Jul 14;8(1):48.  doi: 10.1038/s41572-022-00376-4.

Increased COVID-19 mortality rate in rare disease patients: a retrospective cohort study in participants of the Genomics England 100,000 Genomes project

Huayu Zhang, Johan H. Thygesen, Ting Shi, Georgios V. Gkoutos, Harry Hemingway, Bruce Guthrie, Honghan WuOrphanet Journal of Rare Diseases17, 166 (2022).

Alignment-based conformance checking over probabilistic events

Jiawei Zheng, Petros Papapanagiotou, Jacques D. Fleuriot, arXiv 2209.04309 

Effectiveness of holistic assessment-based interventions in improving outcomes in adults with multiple long-term conditions and/or frailty: an umbrella review protocol

Arakelyan, Stella; Lone, Nazir; Anand, Atul; Mikula-Noble, Nataysia; J Lyall, Marcus; De Ferrari, Luna; Mercer, Stewart W.; Guthrie, Bruce, JBI Evidence Synthesis ():10.11124/JBIES-22-00406, May 4, 2023, DOI: 10.11124/JBIES-22-00406

Identifying dementia using medical data linkage in a longitudinal cohort study: Lothian Birth Cohort 1936

Donncha S. Mullin, Lucy E. Stirland, Emily Buchanan, Catherine-Anne Convery, Simon R. Cox, Ian J. Deary, Cinzia Giuntoli, Holly Greer, Danielle Page, Elizabeth Robertson, Susan D. Shenkin, Anna Szalek, Adele Taylor, Georgina Weatherdon, Tim Wilkinson & Tom C. Russ, BMC Psychiatry volume 23, Article number: 303 (2023), 

A comparative overview of health and social care policy for older people in England and Scotland, United Kingdom (UK)

Navneet Aujla, Helen Frost, Bruce Guthrie, Barbara Hanratty, Eileen Kaner, Amy O'Donnell, Margaret E. Ogden, Helen G. Pain, Susan D. Shenkin, Stewart W. Mercer, 

Impact of MidMed, a general practitioner-led modified comprehensive geriatric assessment for patients with frailty

Helen E Jones, Atul Anand, Iain Morrison, Simon Hurding, Sarah H Wild, Stewart W Mercer, Susan D Shenkin, Age and Ageing, Volume 52, Issue 3, March 2023,

The impact of varying the number and selection of conditions on estimated multimorbidity prevalence: A cross-sectional study using a large, primary care population dataset

Clare MacRae, Megan McMinn, Stewart W. Mercer, David Henderson, David A. McAllister, Iris Ho, Emily Jefferson, Daniel R. Morales, Jane Lyons, Ronan A. Lyons, Chris Dibben, Bruce Guthrie, PLOS Medicine

General practitioner-led adapted comprehensive geriatric assessment for frail older people: a multi-methods evaluation of the ‘Living Well Assessment’ quality improvement project in Scotland

Eddie Donaghy, Franca Still, Helen Frost, Julia Lutte, Susan Shenkin, Helen Jones and Stewart Mercer, BJGP Open 23 December 2022; BJGPO.2022.0184. DOI:

Developing a care home data platform in Scotland: a mixed methods study of data routinely collected in care homes

Susan D Shenkin, Lucy Johnston, Jo Hockley, David A G Henderson, Age Ageing 2022 Dec 5;51(12), doi: 10.1093/ageing/afac265 

Alignment-based conformance checking over probabilistic events

Jiawei Zheng, Petros Papapanagiotou, Jacques D. Fleuriot, Conference Abstract, 

The impact of inconsistent human annotations on AI driven clinical decision making

Aneeta Sylolypavan, Derek Sleeman, Honghan Wu & Malcolm Sim, npj Digital Medicine volume 6, Article number: 26 (2023)

A survey on clinical natural language processing in the United Kingdom from 2007 to 2022

Honghan Wu, Minhong Wang, Jinge Wu, Farah Francis, Yun-Hsuan Chang, Alex Shavick, Hang Dong, Michael T. C. Poon, Natalie Fitzpatrick, Adam P. Levine, Luke T. Slater, Alex Handy, Andreas Karwath, Georgios V. Gkoutos, Claude Chelala, Anoop Dinesh Shah, Robert Stewart, Nigel Collier, Beatrice Alex, William Whiteley, Cathie Sudlow, Angus Roberts & Richard J. B. Dobson, npj Digital Medicine, volume 5, Article number: 186 (2022)

Understanding Pathways into Care homes using Data (UnPiCD study): a retrospective cohort study using national linked health and social care data 

Jennifer Kirsty Burton, Giorgio Ciminata, Ellen Lynch, Susan D Shenkin, Claudia Geue, Terence J Quinn, Age and Ageing, Volume 51, Issue 12, December 2022,

The association between multimorbidity and mobility disability-free life expectancy in the very old: A modelling study in the Newcastle 85+ cohort

Laurie E Davies, Stewart W Mercer, Katie Brittain, Carol Jagger, Louise Robinson, Andrew Kingston, PLOS Medicine 19(11): e1004130, 

Effect of competing mortality risks on predictive performance of the QFracture risk prediction tool for major osteoporotic fracture and hip fracture: external validation cohort study in a UK primary care population

Shona J Livingstone, Daniel R Morales, Megan McMinn, Chima Eke, Peter Donnan and Bruce Guthrie, BMJ Medicine 2022. doi: 10.1136/bmjmed-2022-000316

Does polypharmacy shape dependency transitions in the very old? Findings from the Newcastle 85+ Study

Laurie E Davies, Adam Todd, Louise Robinson, Andrew Kingston, Age and Ageing, Volume 51, Issue 10, October 2022, 

Foundation Level Barriers to the Widespread Adoption of Digital Solutions by Care Homes: Insights from Three Scottish Studies

Lucy Johnston, Heidi Koikkalainen, Lynda Anderson, Paul Lapok, Alistair Lawson, Susan D. Shenkin, Int. J. Environ. Res. Public Health 2022, 19(12), 7407,

The association between the discharge of patients from hospitals and COVID in care homes

A consensus statement from the Social Care Working Group to the Scientific Advisory Group for Emergencies (SAGE), Bruce Guthrie, Adelina Comas-Herrera, Dimple Chudasama, Jackie Cassell, Rich Fry, Ian Hall, Éamonn O’Moore and wider Social Care Working Group participants. Read publication here,

Commercial Off-the-Shelf Components (COTS) in Realizing Miniature Implantable Wireless Medical Devices: A Review

Sadeque Reza Khan, Andrew J. Mugisha, Andreas Tsiamis and Srinjoy Mitra, MDPI Sensors 2022, 22(10), 3635;

Wireless Battery-Free Body Temperature Sensing Device for Key Workers

Amin Rigi; Andrew J. Mugisha; Ahmed Arefian; Sadeque Reza Khan; Srinjoy Mitra, IEEE Vol 6. Issue 2,

Describing transitions in residential status over 10 years in the very old: results from the Newcastle 85+ Study

Laurie E Davies, Katie Brittain, Heather Wilkinson, Sue Lewis, Louise Robinson, Andrew Kingston, Age and Ageing - British Geriatrics Society, Volume 51, Issue 3, March 2022,

Integration of health and social care: necessary but challenging for all

Stewart Mercer, David Henderson, Huayi Huang, Eddie Donaghy, Ellen Stewart, Bruce Guthrie and Harry Wang, British Journal of General Practice, 2021; 71 (711): 442-443, Read the publication here

The Use of Telemonitoring in Managing the COVID-19 Pandemic: Pilot Implementation Study

Brian McKinstry;  Helen Alexander;  Gabriela Maxwell;  Lesley Blaikie;  Sameer Patel;  Bruce Guthrie;  Technology Enabled Care TeleCOVID Group, Journal of Medical Internet Research, JMIR Form Res 2021;5(9):e20131, Read the publication here

Classification of Alzheimers Disease using RF Signals and Machine Learning

Saied, I., Arslan, T., Chandran, S, IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology. 2021, Read the publication here

Care-home outbreaks of COVID-19 in Scotland March to May 2020: national linked data cohort analysis

Burton JK, McMinn M, Vaughan J, Fleuriot J, Guthrie B, Age and Ageing. 2021. Volume 50, Issue 5, September 2021, Pages 1482–1492, Read the publication here

Area effects on the level and development of social exclusion in later life

Prattley, J., Buffel, T., Marshall, A., Nazroo, J, Social Science and Medicine. 2020;246(3): 1-11, Read the publication here

Closing the UK care home data gap – methodological challenges and solutions

Burton JK, Goodman C, Guthrie B, Gordon AL, Hanratty B, Quinn TJ, International Journal of Population Data Science. 2020;5(4): 1-6, Read the publication here

Evolution and impact of COVID-19 outbreaks in care-homes: population analysis in 189 care-homes in one geographic region

Burton JK, Bayne G, Evans C, Garbe F, Gorman D, Honhold N, McCormick D, Othieno R, Stevenson J, Swietlik S, Templeton KE, Tranter M, Willocks L, Guthrie B, Lancet Healthy Longevity. 2020;1(1): E21-E31, Read the publication here

Discharges from NHSScotland hospitals to care homes

Management Information Statistics publication for Scotland. 2020;1(1): 1-94, Read the publication here