Clinical Surgery

Professor Damian J Mole

Damian’s research is driven by a vision to produce innovative solutions to difficult surgical problems and challenging diseases. His research strategy is based on a critical questioning approach, disease mechanism evaluation and seeking out and building the best teams to discover and deliver these solutions. His current specific challenges are centered on mechanism evaluation and therapies for multiple organ dysfunction triggered by severe acute pancreatitis, and on harnessing the power of regeneration for tissue restitution.

Professor Damian J Mole

Professor of Clinical and Experimental Surgery, Senior Clinical Lecturer and Honorary Consultant Surgeon

Current Research and Funding

Damian’s research is driven by a vision to produce innovative solutions to difficult surgical problems and challenging diseases. His research strategy is based on a critical questioning approach, disease mechanism evaluation and seeking out and building the best teams to discover and deliver these solutions. His current specific challenges are centered on mechanism evaluation and therapies for multiple organ dysfunction triggered by severe acute pancreatitis, and on harnessing the power of regeneration for tissue restitution.

Damian has recently been awarded a Senior Clinical Fellowship from the Medical Research Council to study cell and organ senescence after acute pancreatitis -  MRC Senior Clinical Fellowship

Together with Perspectum Diagnostics and Basingstoke HPB Unit, Damian is leading an InnovateUK Biomedical Catalyst collaboration to improve imaging assessment of liver health prior to surgery - InnovateUK Biomedical Catalyst

Damian collaborates with GSK through the Discovery Partnerships with Academia (DPAc scheme). Damian holds one of 10 prestigious DPAc awards worldwide. The goal is to develop a new medicine to prevent and treat multiple organ failure triggered by severe acute pancreatitis. He works closely with the Drug Discovery Core and Edinburgh Bioquarter commercialization team.

GSK Discovery Partnerships with Academia

Drug Discovery Core

Damian is currently leading a UK and international consortium of patients, clinicians, academics and industry partners to define critical illness trajectories in acute pancreatitis: the APPreSci (Acute Pancreatitis Precision Science) Consortium. APPreSci is through to the final round of the current MRC Stratified Medicines Initiative call - APPreSci Consortium

Damian believes Edinburgh leads in transforming global healthcare. - Transforming Global Healthcare

Damian has recently held major awards from the MRC (DPFS pilot portfolio award) and Wellcome Trust (Institutional Strategic Support Fund).

Damian is a Developing Principal Investigator in the MRC Centre for Inflammation Research, University of Edinburgh. He is a graduate of the Health Foundation Leadership Training Program.

Developing Principal Investigator

MRC Centre for Inflammation Research

Health Foundation Leadership Training Program

Clinical Interests

Damian’s clinical focus is on the surgical management of benign and malignant disorders of the liver, pancreas and bile ducts. In addition to contributing to the tertiary referral HPB specialist team at the Royal Infirmary of Edinburgh, he periodically leads the Emergency General Surgery receiving team and manages common elective general surgical conditions.

Damian is leading a reorganisation of HPB Cancer Referral Pathways in Scotland in collaboration with the Innovative Healthcare Delivery Programme and Farr@Scotland - IHDP Farr@Scotland

Damian is Year 3 Director of the ESSQ program - ESSQ program

Current Appointments

  • MRC Senior Clinical Fellow, MRC Centre for Inflammation Research.
  • Honorary Consultant HPB Surgeon, Royal Infirmary of Edinburgh.
  • Year 3 Director, ESSQ.

Qualifications

  • 1995 BMedSc (Hons) Cell and Molecular Pathology, First Class, University of Birmingham.
  • 1998 MBChB (Hons and Distinctions) University of Birmingham.
  • 2006 PhD “Mechanisms of pancreatitis-associated organ failure”. Queen’s University of Belfast, including research sabbatical at UMDNJ, New Jersey USA.
  • 2012 FRCS (GenSurg) HPB subspecialty examination.

Research Team

Postdoctoral Research Associate

  • 2008 to present: Dr Xiaozhong Zheng PhD - Research Associate, MRC Centre for Inflammation Research

Postgraduate Doctoral Students

  • 2016 to 2020: Miss Lucile Neyton MSc – MRC Developmental Training Pathway in Precision Medicine (towards PhD). Integrated systems biology of multiple organ dysfunction in acute pancreatitis - MRC DTP in Precision Medicine
  • 2016: Miss Soudabeh Rad Pour – Erasmus+ visiting PhD student from the Karolinska Institute. Metabolic flux in tumour immunity.
  • 2014 to 2017: Mr Alastair J Hayes MRCS – Clinical research training fellow (towards PhD) Amelie Waring Fellowship, CORE. Resolution of Inflammation in Experimental Acute Pancreatitis - Amelie Waring Fellowship
  • 2012 to 2016: Mr Christos Skouras MRCS – Clinical research training fellow (towards MD)– Observational Experimental Study in Acute Pancreatitis in Humans
  • 2011 to 2014: Dr Kris Wilson PhD – MRC Research Training Fellow – PhD awarded 2014. Novel drug discovery methodologies

MSc by Research Students

  • 2015-2016: Mr Toby Murray BMedSc - MSc by Research. Kynurenine Pathway Pharmacokinetics in rodents. Recipient of Royal College of Surgeons of England Intercalated Degree Bursary
  • 2014 to 2015: Francesca Th'ng MB ChB - MSc by Research awarded 2015. Circulating miRNA bio-markers of inflammatory complications of biliary tract disease. Co-supervised with Dr James Dear (Senior Lecturer in Toxicology). Project funded by Lothian Health Foundation

Publications

A list of Damian Moles publications can be found by clicking here.