Current Research

Research using the SDRNT1BIO aims to identify those most at risk of diabetes complications, and to investigate potential early-warning indicators of possible future complications.

Current Projects

To date biosamples have been used for DNA extraction and genome-wide genotyping. Serum samples have been used for the measurement of several biomarkers of interest including C-peptide, serum creatinine and auto-antibodies (GAD, ZnT8, IA2). Journal papers reporting on the findings of these studies will be finalised over the coming months. We have also carried out N-glycome analysis on blood samples, which looks at the association between changes in the structure of important signalling complex molecules and the development of diabetic kidney disease.

The current research projects in 2017-18 are:

• Glycaemia Trajectories in Type 1 Diabetes and their Association with Complications (Diabetes UK funded)
• Harnessing genetic information in the SDRNT1BIO to understand Type 1 diabetes and its complications (Diabetes UK funded)
• Extreme Phenotypes Relevant to Diabetic Complications in Type 1 Diabetes (JDRF funded)
• Validation of Novel and Candidate Biomarkers for Diabetic Kidney Disease in Large Cohorts of people with Type 1 Diabetes (JDRF funded)
• Predictors of Early Stage Decline in Kidney Function in Type 1 Diabetes (JDRF funded)

Collaboration

The Study is managed under a supported collaboration model and includes researchers from a wide range of institutes:

• Broad Institute
• Folkhälsan
• Generation Scotland
• Genos
• Harvard University
• Joslin diabetes Center
• King’s College London
• Steno Diabetes Center
• University of California
• University of Cambridge
• University of Dundee
• University of Exeter
• University of Glasgow
• University of Michigan
• University of Pittsburgh
• University of Toronto
• University of Washington
• University of Wisconsin

Collaborating laboratories that are carrying out biomarker measurements on SDRNT1BIO samples include:

• Myriad RBM, Texas USA
• National Institute of Bioprocessing Research and Training (NIBRT), Dublin Ireland
• Immunoassay Biomarker Core Laboratory, Dundee UK
• Wellcome Trust Clinical Research Facility, Edinburgh UK
• Exeter Clinical Laboratory, Royal Devon and Exeter Hospital, Exeter UK
• Well Child Laboratory, King’s College London UK

Interested collaborators should contact the Study Coordinator in the first instance, email SDRNT1BIO@ed.ac.uk.

Published Papers

• Bermingham ML, Colombo M, McGurnaghan S, Blackbourn LAK, Vučković FM Pučić Baković, Trbojević-Akmačić I, Lauc G, Agakov F, Agakova AS, Hayward C, Klarić L, Palmer CNA, Petrie JR, Chalmers J, Collier A, Green F, Lindsay RS, Macrury S, McKnight JA, Patrick AW, Thekkepat S, Gornik O, McKeigue PM and Colhoun HM, on behalf of the SDRN Type 1 Bioresource Investigators. N-Glycan Profile and Kidney Disease in Type 1 Diabetes. Diabetes Care. Nov 2017 DOI: 10.2337/dc17-1042
• Akbar T, McGurnaghan S, Palmer CNA, Livingstone SJ, Petrie JR, Chalmers J, Lindsay RS, McKnight J, Pearson D W M, Patrick AW, Walker J, Looker HC, Colhoun HM. Cohort Profile: Scottish Diabetes Research Network Type 1 Bioresource Study (SDRNT1BIO). International Journal of Epidemiology. Oct 2016 DOI: 10.1093/ije/dyw152

Abstracts Presented

• McKeigue PM, Spiliopoulou A, McGurnaghan S, Colombo M, McDonald TJ, Colhoun HM, on behalf of the SDRNT1BIO investigators. Genotypic Associations with C-peptide Persistence in People with Type 1 Diabetes. Oral presentation at the American Diabetes Association Meeting in Orlando, June 2018
• Colombo M, Valo E, McGurnaghan S, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM on behalf of the SDRNT1BIO and FinnDiane study group. A Bayesian approach for the discovery of biomarkers of progression of nephropathy. Oral presentation at the 31^st Annual General Meeting of the EDNSG in Groningen, June 2018
• Colombo M, McGurnaghan S, Bell S, Palmer C, MacKenzie F, Chalmers J, Collier A, Green F, Lindsay RS, Macrury S, McKnight JA, Patrick AW, Pearson DW, Petrie J, Thekkepat S, McKeigue P, Colhoun HM on behalf of the SDRNT1BIO investigators. Contemporary Rates and Predictors of Renal Disease Progression in Type 1 Diabetes. Poster presentation at the 77^th American Diabetes Association Scientific Session, June 2017.
• Bermingham ML, Colombo M, McGurnaghan S, Blackbourn L, Vučković F, Pučić Baković M, Lauc G, Agakov FA, Agakov AS, Hayward C, Klaric L, McKeigue PM, Colhoun HM, SDRNT1BIO investigators. Polymorphisms in ST3GAL4, ST6GAL1, PHIP, FUT8 are associated with variation within the serum N-glycome of Scottish type 1 diabetes patients. Poster presentation at the 53^rd EASD Annual Meeting in Lisbon, June 2017.
• Colombo M, Valo E, McGurnaghan S, Blackbourn L, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM, on behalf of the SDRNT1BIO and Finndiane Investigators. Biomarkers associated with progression of renal disease in type 1 diabetes. Poster presentation at the 53^rd EASD Annual Meeting in Lisbon, June 2017.
• Colombo M, Valo E, McGurnaghan S, Dalton RN, Dunger D, Groop PH, McKeigue PM, Forsblom C, Colhoun HM, on behalf of the SDRNT1BIO and Finndiane Investigators. Biomarkers associated with progression of renal disease in type 1 diabetes. Oral presentation at the 30^th Annual General Meeting of the EDNSG in Helsinki, May 2017.
• Colombo M, Vuckovic F, Pucic-Bakovic M, Looker H, Agakov F, Lauc, G, McKeigue PM, Colhoun HM on behalf of the SDRNT1BIO investigators. Associations of serum N-glycans with glycaemic control and albuminuria in type 1 diabetes. Poster presentation at the 51^st EASD Annual Meeting, June 2015
• Looker H, Livingstone S, McGurnaghan S, Collier A, Green F, Lindsay RS, MacRury S, McKnight JA, Milburn K, Palmer CAN, Patrick AW, Pearson DWM, Pearson ER, Petrie JR, Thekkepat S, Walker J, Colhoun HM, on behalf of the SDRNT1BIO investigators. Patterns of Glucose and Diabetes Management among Scottish Diabetes Research Network Type 1 Diabetes Bioresource participants. Poster presented at the Diabetes UK conference in London, March 2015