Control of Infectious Diseases
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Novel therapeutics against viral diseases

Scientists show that a chemical inhibitor of a cell factor (VCP) is a potent antiviral.

Costaining of VCP and IE2 showing localization of VCP to the viral replication compartments in the nucleous
Costaining of VCP and IE2 showing localization of VCP to the viral replication compartments in the nucleus.

Researchers at The Roslin Institute have identified a host cell factor required for replication of certain types of viruses including human cytomegalovirus.  

The cellular factor - called valosin containing protein (VCP) - is essential for virus replication. Finn Grey and colleages show that a chemical inhibitor of VCP acts as a potent antiviral, highlighting the potential of VCP inhibitors as novel therapeutics against this and related viral diseases.

For further information please see our news story.

Original publication

Lin Y-T, Prendergast J, Grey F (2017) The host ubiquitin-dependent segregase VCP/p97 is required for the onset of human cytomegalovirus replication. PLoS Pathog 13(5): e1006329. https://doi.org/10.1371/journal.ppat.1006329