Improving Animal Welfare Production Traits

Molecular control of sex determination and gonadal development. Mechanisms underlying sexual dimorphisms in birds. Micro-RNA regulation of cell and tissue differentiation.

Pathophysiologic mechanisms underlying lung disease.

I lead a research group working in the areas of Stem Cell biology and Reproductive Biology in large animal species. We are interested in these species both from a veterinary perspective and as disease models.  Work in my laboratory spans from hypothesis-led studies to understand basic cell, organ and whole animal biology and physiology, all the way through to translational studies with industry to develop novel molecular diagnostics and cell-based therapies to address specific key challenges faced by the livestock (cattle) industry and companion animal sectors. My laboratory is best known for pioneering work on 1) the use of miRNAs as novel diagnostic biomarkers for cattle, and 2) the generation and application of stem cells, particularly induced pluripotent stem cells (iPSCs), in farm species (horse, cattle, pigs). 

Development, maintenance and repair of the skin and its appendages.

Preclinical studies to evaluate safety and efficacy of vectors for respiratory gene/miRNA delivery in mice & sheep. Sheep as a large animal model for respiratory disease.

Adaptations of the neuroendocrine system: hormonal and neural regulation of reproduction and behaviour.  Animal Welfare: Neurobiology of positive welfare and behaviour.

Development of genetically engineered livestock for biomedical and agricultural applications.