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How vitamin D affects the immune system

Scientists have uncovered fresh insights into how vitamin D affects the immune system and might influence susceptibility to diseases such as multiple sclerosis.

Sunset and mountains
Researchers found that vitamin D affects key cells of the immune system.

Vitamin D is produced by the body in response to sunlight and is often lauded for its health benefits. Researchers found it also affects key cells of the immune system.

This discovery might explain how vitamin D regulates immune reactions that have been implicated in autoimmune diseases such as multiple sclerosis.

Key mechanism

The University of Edinburgh team focused on how vitamin D affects a mechanism in the body’s immune system – dendritic cells’ ability to activate T cells. In healthy people, T cells play a crucial role in helping to fight infections. In people with autoimmune diseases, however, they can start to attack the body’s own tissues.

By studying cells from mice and people, the researchers found vitamin D caused dendritic cells to produce more of a molecule called CD31 on their surface and that this hindered the activation of T cells. The team observed how CD31 prevented the two cell types from making a stable contact – an essential part of the activation process – and the resulting immune reaction was far reduced.

Disease susceptibility

Researchers say the findings shed light on how vitamin D deficiency may regulate the immune system and influence susceptibility to autoimmune diseases.

Low vitamin D status has long being implicated as a significant risk factor for the development of several autoimmune diseases. Our study reveals one way in which vitamin D metabolites can dramatically influence the immune system.

Professor Richard MellanbyCentre for Inflammation Research and The Roslin Institute, University of Edinburgh

The study, published in the journal "Frontiers of Immunology", was funded by the Medical Research Council, Biotechnology and Biological Sciences Research Council, Natural Environment Research Council and Wellcome.

** The Roslin Institute receives strategic investment funding from the Biotechnology and Biological Sciences Research Council and it is part of the University of Edinburgh’s Royal (Dick) School of Veterinary Studies. **

Related links

Journal article

Centre for Inflammation Research

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