Chromatin Biology and Epigenetics

Published a review in Trends in Genetics

Nov 2015

Doug Vernimmen and Wendy Bickmore published a review in Trends in Genetics entitled: The Hierarchy of Transcriptional Activation: From Enhancer to Promoter

In this review, Doug and Wendy describe how enhancers are primed during cell commitment and how they interact with they cognate promoter. They also argue that the mechanism involved in enhancer-promoter interaction may depend on the distance separating them and that more single locus dissection is required to understand the nature of these interactions.  


Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.

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doi: 10.1016/j.tig.2015.10.004  

UPDATE: A lay friendly description of this paper was published by the Atlas of Science.