Published a review in The Journal of Pathology
Jan 2015
Ailbhe Brazel and Doug Vernimmen published in the annual review issue of the Journal of Pathology: The complexity of epigenetic diseases
In this review, Ailbhe and Doug argue that (in most cases) epigenetic diseases would be genetic after all !
Abstract:
Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.
Download Open Access paper:http://onlinelibrary.wiley.com/doi/10.1002/path.4647/epdf doi: 10.1002/path.4647