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Dr Thomas Wishart

Highlighted Publications

Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivo.

Maria del carmen Llavero hurtado, Heidi R Fuller, Andrew Wong, Samantha Eaton, Thomas Gillingwater, Giuseppa Pennetta, Jonathan Cooper, Thomas Wishart Scientific Reports Pages: 7 29 Sep 2017

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Molecular correlates of axonal and synaptic pathology in mouse models of Batten disease

C. Kielar, T. M. Wishart, A. Palmer, S. Dihanich, A. M. Wong, S. L. Macauley, C. H. Chan, M. S. Sands, D. A. Pearce, J. D. Cooper, T. H. Gillingwater Human Molecular Genetics Vol: 18 Pages: 4066-4080 Nov 2009

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Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1

Jamie Mcqueen, Tomás J Ryan, Sean Mckay, Katie Marwick, Paul Baxter, Sarah M. Carpanini, Thomas Wishart, Thomas Gillingwater, Jean Manson, David Wyllie, Seth Grant, Barry McColl, Noboru Komiyama, Giles Hardingham eLIFE 21 Jul 2017

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SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy

T. M. Wishart, J. P. W. Huang, Lyndsay Murray, D. J. Lamont, C. A. Mutsaers, J. Ross, P. Geldsetzer, O. Ansorge, K. Talbot, S. H. Parson, T. H. Gillingwater Human Molecular Genetics Vol: 19 Pages: 4216-4228 Nov 2010

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Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy

Penelope J Boyd, Wen-Yo Tu, Hannah K Shorrock, Ewout J N Groen, Roderick N Carter, Rachael A Powis, Sophie R Thomson, Derek Thomson, Laura C Graham, Anna A L Motyl, Thomas M Wishart, J Robin Highley, Nicholas M Morton, Thomas Becker, Catherina G Becker, Paul R Heath, Thomas H Gillingwater PLoS Genetics Vol: 13 20 Apr 2017

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Bridging the Gap: large animal models in neurodegenerative research

Samantha Eaton, Thomas Wishart Mammalian Genome Vol: 28 Pages: 324-337 Aug 2017

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Analysis of gene expression in the nervous system identifies key genes and novel candidates for health and disease

Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, Kim M Summers Neurogenetics Vol: 18 Pages: 81-95 Apr 2017

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Sideroflexin 3 is a α-synuclein-1 dependent mitochondrial protein 2 that regulates synaptic morphology

Ines Amorim, Laura Graham, Roderick Carter, Nicholas Morton, Fella Hammachi, Tilo Kunath, Giuseppa Pennetta, Sarah Carpanini, Jean Manson, Douglas J Lamont, Thomas Wishart, Thomas Gillingwater Journal of Cell Science Vol: 130 Pages: 325-331 15 Jan 2017

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Systemic restoration of UBA1 ameliorates disease in spinal muscular atrophy

Rachael Powis, Evangelia Karyka, Penelope Boyd, Julien Côme, Ross Jones, Yinan Zheng, Eva Szunyogova, Ewout Groen, Gillian Hunter, Derek Thomson, Thomas Wishart, Catherina Becker, Simon H. Parson, Cécile Martinat, Mimoun Azzouz, Thomas Gillingwater JCI Insight Vol: 1 21 Jul 2016

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Understanding the molecular consequences of inherited muscular dystrophies: advancements through proteomic experimentation

Heidi R Fuller, Laura Graham, Maica Llavero Hurtado, Thomas Wishart Expert review of proteomics Vol: 13 Pages: 659-671 22 Jun 2016

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Commonality amid diversity: multi-study proteomic identification of conserved disease mechanisms in spinal muscular atrophy

Heidi R Fuller, Thomas Gillingwater, Thomas Wishart Neuromuscular Disorders Vol: 26 Pages: 560-569 Sep 2016

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In vitro seeding of amyloid plaques

Kirsty A. Ireland, Thomas M. Wishart, Rona Barron Prion Vol: 10 Pages: S45-S46 18 Apr 2016

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Lack of stress protection by the cellular prion protein: An alternative role in regulating growth factor signaling

Andrew R. Castle, Dominic Kurian, Thomas M. Wishart, Andrew C. Gill Prion Vol: 10 Pages: S39-S39 18 Apr 2016

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Equine grass sickness, but not botulism, causes autonomic and enteric neurodegeneration and increases SNARE protein expression within neuronal perikarya

Bruce McGorum, Sandra Scholes, Elspeth Milne, Samantha Eaton, Thomas Wishart, Ian Poxton, Sharon Moss, Ulli Wernery, Tracey Davey, John Harris, Scott Pirie Equine Veterinary Journal Vol: 48 Pages: 786-791 Nov 2016

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Quantitative imaging of tissue sections using infrared scanning technology

Samantha Eaton, Elizabeth Cumyn, Declan King, Rachel A. Kline, Sarah Carpanini, Jorge Del-Pozo, Rona Barron, Thomas Wishart Journal of Anatomy Vol: 228 Pages: 203-213 Jan 2016

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Proteomic profiling of cranial (superior) cervical ganglia reveals Beta-amyloid and ubiquitin proteasome system perturbations in an equine multiple system neuropathy.

Bruce McGorum, Robert Pirie, Samantha Eaton, John Keen, EM Cumyn, DA Arnott, W Chen, DJ Lamont, Laura Graham, M Llavero Hurtado, Alan Pemberton, Thomas Wishart Molecular and Cellular Proteomics Vol: 14 Pages: 3072-3086 14 Sep 2015

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Molecular neuropathology of the synapse in sheep with CLN5 Batten disease

Inês S. Amorim , Nadia L. Mitchell, David N. Palmer, Stephen J. Sawiak, Roger Mason, Thomas Wishart, Thomas Gillingwater Brain and Behavior Vol: 5 Nov 2015

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Dysregulation of ubiquitin homeostasis and beta-catenin signaling promote spinal muscular atrophy

Thomas M Wishart, Chantal A Mutsaers, Markus Riessland, Michell M Reimer, Gillian Hunter, Marie L Hannam, Samantha L Eaton, Heidi R Fuller, Sarah L Roche, Eilidh Somers, Robert Morse, Philip J Young, Douglas J Lamont, Matthias Hammerschmidt, Anagha Joshi, Peter Hohenstein, Glenn E Morris, Simon H Parson, Paul A Skehel, Thomas Becker, Iain M Robinson, Catherina G Becker, Brunhilde Wirth, Thomas H Gillingwater Journal of Clinical Investigation Vol: 124 Pages: 1821-1834 Apr 2014

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Label-free proteomics identifies Calreticulin and GRP75/Mortalin as peripherally accessible protein biomarkers for spinal muscular atrophy

Chantal A. Mutsaers, Douglas J. Lamont, Gillian Hunter, Thomas M. Wishart, Thomas H. Gillingwater Genome Medicine Vol: 5 18 Oct 2013

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Total Protein Analysis as a Reliable Loading Control for Quantitative Fluorescent Western Blotting

Samantha L. Eaton, Sarah L. Roche, Maica Llavero Hurtado, Karla Suchacki, Colin Farquharson, Thomas H. Gillingwater, Thomas M. Wishart PLoS ONE Vol: 8 30 Aug 2013

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Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration In Vivo

Thomas M Wishart, Timothy M Rooney, Douglas J Lamont, Ann K Wright, A Jennifer Morton, Mandy Jackson, Marc R Freeman, Thomas H Gillingwater PLoS Genetics Vol: 8 2012

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Protein Product of CLN6 Gene Responsible for Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis Interacts with CRMP-2

J. W. Benedict, A. L. Getty, T. M. Wishart, T. H. Gillingwater, D. A. Pearce Journal of Neuroscience Research Vol: 87 Pages: 2157-2166 Jul 2009

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