My research aims to understand the pathogenesis of infectious diseases within the immune system. Particular interests include understanding host-pathogen interactions within the mucosal immune system, especially prion diseases and other gastrointestinal pathogens such as Salmonella and nematodes.
Studies are also focused on the effects of host age on the function of the immune system and how this influences susceptibility to gastrointestinal pathogens.
A systems biology approach is also being used to compare the transcriptomic profiles of distinct immune cell populations in the steady-state, and also during ageing.
This research benefits greatly from the availability of precisely defined mouse prion pathogenesis models, unique transgenic and immunodeficient mice and state-of-the-art bio-imaging and bioinformatics expertise.