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Professor Bruce Whitelaw

Professor Bruce Whitelaw

Genus Personal Chair of Animal Biotechnology

Highlighted Publications

An introduction to non-mouse models

B. Whitelaw 2011

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Animal Productivity and Genetic Diversity: Cloned and Transgenic Animals. Animal Agriculture's Future through Biotechnology, Part 8

R. Wall, G. Laible, E. Mega, G. Seiel, C. B. A. Whitelaw 2009

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The germline manipulation of livestock: progress during the past five years.

A. J. Clark, Alan Archibald, M McClenaghan, J. P. Simons, Bruce Whitelaw, Ian Wilmut Proc NZ Soc Animal Prod Vol: 50 Pages: 167-179 1990

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A Csf1r-EGFP transgene provides a novel marker for monocyte subsets in sheep

Clare Pridans, Gemma Davis, Kristin Sauter, Zofia Lisowski, Yolanda Corripio-Miyar, Anna Raper, Lucas Lefevre, Rachel Young, Mary E. McCulloch, Simon Lillico, Elspeth Milne, Christopher Whitelaw, David Hume Journal of Immunology Vol: 197 Pages: 2297-2305 15 Sep 2016

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Hormonal influences on beta-lactoglobulin transgene expression inferred from chromatin structure

C B Whitelaw Biochemical and Biophysical Research Communications Vol: 224 Pages: 121-5 05 Jul 1996

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Production of human α 1 ‐antitrypsin in the milk of transgenic sheep and mice: Targeting expression of CDNA sequences to the mammary gland

M. Mcclenaghan, Alan Archibald, S. Harris, J.p. Simons, Bruce Whitelaw, I. Wilmut, A.j. Clark Animal biotechnology Vol: 2 Pages: 161-176 01 Jan 1991

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Expression of b-lactoglobulin and hybrid transgenes in the mammary gland.

Bruce Whitelaw, Alan Archibald, S. Harris, M McClenaghan, J. P. Simons, C J Watson, Ian Wilmut, A. J. Clark 1990

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Livestock 2.0 – genome editing for fitter, healthier, and more productive farmed animals

Christine Tait-burkard, Andrea Doeschl-wilson, Mike J. Mcgrew, Alan L. Archibald, Helen M. Sang, Ross D. Houston, C. Bruce Whitelaw, Mick Watson Genome Biology Vol: 19 26 Nov 2018

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Recommendations for Minimum Information for Publication of Experimental Pathology Data: MINPEPA Guidelines

C Scudamore, Elizabeth J Soilleux, Natasha A Karp, Ken Smith, Richard Poulsom, Charles Herrington, Michael Day, Cory Brayton, Brad Bolon, Christopher Whitelaw, Eric White, Jeffrey Everitt, Mark Arends The Journal of Pathology Vol: 238 Pages: 359-367 Jan 2016

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Comparative analysis on the structural features of the 5' flanking region of kappa-casein genes from six different species

Akos Gerencsér, Endre Barta, Simon Boa, Petros Kastanis, Zsuzsanna Bösze, C Bruce A Whitelaw Genetics Selection Evolution Vol: 34 Pages: 117-28 2002

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Transgenic animals as bioreactors

Bruce Whitelaw AgBiotech News and Information Vol: 4 Pages: 371N-372N 1992

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Erratum to: Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs

Janez Jenko, Gregor Gorjanc, Matthew A Cleveland, Rajeev K Varshney, C Bruce A Whitelaw, John A Woolliams, John M Hickey Genetics Selection Evolution Vol: 47 Pages: 69 13 Sep 2015

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Transgenic animal welfare

B Whitelaw Transgenic Research Vol: 10 Pages: 375 Oct 2001

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Cardiac Specific Gene Expression Changes in Long Term Culture of Murine Mesenchymal Stem Cells

H.M. Hodgkiss-Geere, D.J. Argyle, B.M. Corcoran, B. Whitelaw, E. Milne, D. Bennett, S.A. Argyle International Journal of Stem Cells Vol: 4 Pages: 143-148 2011

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Novel GM Animal Technologies and their Governance

Ann Bruce, David Castle, Corinna Gibbs, Joyce Tait, Bruce Whitelaw Transgenic Research Vol: 22 Pages: 681-695 Aug 2013

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Genotype Selection and Modification and the Future of Livestock Production

D. A. Hume, C. B. A. Whitelaw, A. L. Archibald 2012

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Comparable processing of beta-lactoglobulin pre-mRNA in cell culture and transgenic mouse models

G Donofrio, E Bignetti, A J Clark, C B Whitelaw Molecular & general genetics Vol: 252 Pages: 465-9 25 Sep 1996

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A strategy to exploit surrogate sire technology in livestock breeding programs

Paolo Gottardo, Gregor Gorjanc, Mara Battagin, Robert Gaynor, Janez Jenko, Roger Ros Freixedes, Christopher Whitelaw, Alan Mileham, William O. Herring, John Hickey G3 Vol: 9 Pages: 203-215 Jan 2019

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Advances in animal biotechnology: Embryo micromanipulation and gene transfer

Ian Wilmut, D.N. Wells, J McWhir, M. L. Hooper, W. A. Ritchie, Bruce Whitelaw, Alan Archibald, M McClenaghan, J. P. Simons, A. J. Clark 1991

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Comparison of CRISPR/Cas9 and TALENs on editing an integrated EGFP gene in the genome of HEK293FT cells

Zuyong He, Christopher Proudfoot, Christopher Whitelaw, Simon Lillico SpringerPlus Vol: 5 21 Jun 2016

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Welfare assessment in transgenic pigs expressing green fluorescent protein (GFP)

R. C. Huber, L. Remuge, A. Carlisle, S. Lillico, P. Sandoe, D. B. Sorensen, Bruce Whitelaw, I. A. S. Olsson Transgenic Research Vol: 21 Pages: 773-784 2012

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Behaviour of postnatally growth-impaired mice during malnutrition and after partial weight recovery

Reinhard C. Huber, Andreas F. Kolb, Simon Lillico, Ailsa Carlisle, Peter Sandoe, Dorte B. Sorensen, Liliana Remuge, Bruce C. A. Whitelaw, Anna I. S. Olsson Nutritional neuroscience Vol: 16 Pages: 125-134 Mar 2013

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Bovine telomere dynamics and the association between telomere length and productive lifespan

Luise A Seeker, Joanna Warner, Androniki Psifidi, Rachael Wilbourn, Sarah Underwood, Jennifer Fairlie, Rebecca Holland, Hannah Froy, Eliane Salvo-Chirnside, Ainsley Bagnall, Christopher Whitelaw, Mike Coffey, Daniel Nussey, Georgios Banos Scientific Reports Vol: 8 24 Aug 2018

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CD13 is a negative regulator of Fc epsilon RI dependent mast cell activation in vitro and anaphylaxis in vivo

Florian Wölbing, J. Marschall, C. Lassnig, U. Schulte, A. Kolb, Bruce Whitelaw, M. Mueller, T. Biedermann, M. Huber 2012

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TT2016 meeting report on the 13th Transgenic Technology meeting in Prague, Czech Republic

Susan Tamowski, Jinping Luo, Benoît Kanzler, Bruce Whitelaw, Martina Crispo, Lynn Doglio, Boris Jerchow, Jan Parker-Thornburg Transgenic Research 08 Jun 2016

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Investigating the role of PRDM14 in avian germ cell development using an inducible transposon system

James Glover, M. McGrew, H. Sang, B. Whitelaw, L. Taylor 2011

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Control of mammary involution by insulin-like growth factor binding proteins: role of prolactin

D.j. Flint, E. Tonner, C.h. Knight, Bruce Whitelaw, J. Webster, M. Barber, G. Allan Livestock Production Science Vol: 70 Pages: 115-120 01 Jul 2001

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Stat5 as a target for regulation by extracellular matrix

C H Streuli, G M Edwards, M Delcommenne, C B Whitelaw, T G Burdon, C Schindler, C J Watson Journal of Biological Chemistry Vol: 270 Pages: 21639-44 15 Sep 1995

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Targeting gene expression to the mammary gland

A. J. Clark, Alan Archibald, M McClenaghan, J. P. Simons, Bruce Whitelaw, Ian Wilmut 1991

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Pharmaceuticals from transgenic sheep

Bruce Whitelaw Biological Sciences Review Vol: 7 Pages: 25-27 1995

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Use of Genome Editing in Animal Breeding P rograms

Janez Jenko, Gregor Gorjanc, Gabor Meszaros, Bruce Whitelaw, John Woolliams, Matthew A. Cleveland, John Hickey 2014

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The molecular manipulation of milk

Bruce Whitelaw, Alan Archibald, F E Hitchin, M McClenaghan, J. P. Simons, C J Watson, Ian Wilmut, A. J. Clark 1990

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Dolly for dinner? Assessing commercial and regulatory trends in cloned livestock

J Suk, A Bruce, R Gertz, C Warkup, C B A Whitelaw, A Braun, C Oram, E Rodríguez-cerezo, I Papatryfon Nature Biotechnology Vol: 25 Pages: 47-53 01 Jan 2007

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Virus-neutralizing monoclonal antibody expressed in milk of transgenic mice provides full protection against virus-induced encephalitis

A F Kolb, L Pewe, J Webster, S Perlman, C B Whitelaw, S G Siddell Journal of Virology Vol: 75 Pages: 2803-9 Mar 2001

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TT2013 meeting report: the Transgenic Technology meeting visits Asia for the first time

Douglas Strathdee, C Bruce A Whitelaw Transgenic Research Vol: 22 Pages: 667-71 Jun 2013

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Of mice and pigs - tackling the lack of welfare assessment (protocols) in transgenic farms animals

R. Huber, D.B. Sorensen, P. Sandoe, B. Whitelaw, A.S. Olssen 2009

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Tissue-specific, temporally regulated expression mediated by the proximal ovine beta-lactoglobulin promoter in transgenic mice

J Webster, R M Wallace, A J Clark, C B Whitelaw Cellular & molecular biology research Vol: 41 Pages: 11-5 1995

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New insights and current tools for genetically engineered (GE) sheep and goats

A. Menchaca, I. Anegon, Bruce Whitelaw, H. Baldassarre, M. Crispo Theriogenology Vol: 86 Pages: 160-169 01 Jul 2016

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Characterisation and cardiac directed differentiation of canine adult stem cells

H. Hodgkiss-Geere, D. Argyle, B. Corcoran, E. Milne, Bruce Whitelaw, D. Bennett, S. Argyle 2010

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GENETICALLY-EDITED SWINE

Christopher Whitelaw, Simon Lillico 2017

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p21 (WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program

L.Y. Pang, M. Scott, R.L. Hayward, H. Mohammed, C.B. Whitelaw, G.C. Smith, T.R. Hupp Cell Cycle Vol: 10 Pages: 932-950 2011

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Regulation of ovine beta-lactoglobulin gene expression during the first stage of lactogenesis

C B Whitelaw Biochemical and Biophysical Research Communications Vol: 209 Pages: 1089-93 26 Apr 1995

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Frequency of germline mosaicism in founder transgenic mice

Bruce Whitelaw, Alan Archibald, Stephen Harris, Maggie McClenaghan, Anthea Springbett, Paul J Simons, Roberta Wallace, John A. Clark Mouse Genome Vol: 88 Pages: 114 1990

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In Vitro and in Vivo nucleosome positioning on the ovine beta-lactoglobulin gene are related

Marieta Gencheva, Simon Boa, Ross Fraser, Martin Simmen, Bruce Whitelaw, James Allan Journal of Molecular Biology Vol: 361 Pages: 216 11 Aug 2006

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A preliminary proteomic characterisation of extracellular vesicles released by the ovine parasitic nematode, Teladorsagia circumcincta

Thomas Tzelos, Jacqueline B Matthews, Amy H Buck, Fabio Simbari, David Frew, Neil F Inglis, Kevin McLean, Alasdair J Nisbet, C Bruce A Whitelaw, David P Knox, Tom N McNeilly Veterinary Parasitology Vol: 221 Pages: 84-92 15 May 2016

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Potential of promotion of alleles by genome editing to improve quantitative traits in livestock breeding programs

Janez Jenko, Gregor Gorjanc, Matthew A Cleveland, Rajeev K Varshney, C Bruce A Whitelaw, John A Woolliams, John M Hickey Genetics Selection Evolution Vol: 47 02 Jul 2015

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Frontiers in transgenic research

P Christou, B Whitelaw Transgenic Research Vol: 9 Pages: 241-2 2000

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USP18 restricts PRRSV growth through alteration of nuclear translocation of NF-κB p65 and p50 in MARC-145 cells

Dequan Xu, Simon G. Lillico, Mark W. Barnett, Christopher B. A. Whitelaw, Alan L. Archibald, Tahar Ait-Ali Virus Research Vol: 169 Pages: 264-267 Oct 2012

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Nanos knock-out that ablates germline cells.

Jon M. Oatley, Christopher Whitelaw, Simon Lillico, Bhanu Telugu 2015

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Meeting Report: UC Davis Transgenic Animal Research Conference VI: Granlibakken Conference Center, Tahoe City, California, August 12–16, 2007

James D. Murray, Bruce Whitelaw, Lluís Montoliu Transgenic Research Vol: 16 Pages: 835-837 05 Nov 2007

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Domain 5 of cd163 for use in antiviral compositions against prrs, and transgenic animals

Tahar Ait-Ali, Simon Lillico, Alan Archibald, Christopher Whitelaw 2014

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Genetics and Biosynthesis of Milk Proteins

J. L. Vilotte, E. Chanat, F. Le Provost , Bruce Whitelaw, A. Kolb, D. B. Shennan 2013

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Nucleosome organisation of the beta-lactoglobulin gene. Transcription complex formation

C B Whitelaw Advances in Experimental Medicine and Biology Vol: 480 Pages: 147-53 2000

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Derivation and Characterization of Induced Pluripotent Stem Cells from Equine Fibroblasts

Amandine Breton, Ruchi Sharma, Andrea Catalina Diaz, Alea Gillian Parham, Audrey Graham, Claire Neil, Christopher Bruce Whitelaw, Elspeth Milne, Francesc Xavier Donadeu Stem Cells and Development Vol: 22 Pages: 611-621 Feb 2013

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Milk Lacking α-Casein Leads to Permanent Reduction in Body Size in Mice

Andreas F Kolb, Reinhard C Huber, Simon G Lillico, Ailsa Carlisle, Claire J Robinson, Claire Neil, Linda Petrie, Dorte B Sorensen, I Anna S Olsson, C Bruce A Whitelaw PLoS ONE Vol: 6 2011

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Ectopic expression of beta-lactoglobulin transgenes

E Farini, C B Whitelaw Molecular & general genetics Vol: 246 Pages: 734-8 20 Mar 1995

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Marker genes for activation of the RNA interference (RNAi) pathway in the free-living nematode Caenorhabditis elegans and RNAi development in the ovine nematode Teladorsagia circumcincta

T. Tzelos, J. B. Matthews, B. Whitelaw, D. P. Knox Journal of helminthology Vol: 89 Pages: 208-216 01 Jan 2015

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Transgenic embryos and mice produced from low titre lentiviral vectors

William A Ritchie, Claire Neil, Tim King, C Bruce A Whitelaw Transgenic Research Vol: 16 Pages: 661-4 Oct 2007

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Gene targeting, genome editing: from Dolly to editors

C. B. Whitelaw Transgenic Research Vol: 25 Pages: 102-103 2016

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Characterisation and differentiation potential of bone marrow derived canine mesenchymal stem cells

H. M. Hodgkiss-Geere, D. J. Argyle, B. M. Corcoran, B. Whitelaw, E. Milne, D. Bennett, S. A. Argyle Veterinary Journal Vol: 194 Pages: 361-368 2012

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Chromosomal position effects and the modulation of transgene expression

A J Clark, P Bissinger, D W Bullock, S Damak, R Wallace, C B Whitelaw, F Yull Reproduction, Fertility and Development Vol: 6 Pages: 589-98 1994

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Global gene expression analysis of canine osteosarcoma stem cells reveals a novel role for COX-2 in tumour initiation

Lisa Pang, Emma Gattenby, Ayako Kamido, Bruce Whitelaw, Ted Hupp, David Argyle PLoS ONE Vol: 9 2014

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Prolactin inhibits cell loss and decreases matrix metalloproteinase expression in the involuting mouse mammary gland but fails to prevent cell loss in the mammary glands of mice expressing IGFBP-5 as a mammary transgene

D J Flint, M Boutinaud, C B A Whitelaw, G J Allan, A F Kolb Journal of molecular endocrinology Vol: 36 Pages: 435-48 Jun 2006

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Pigs lacking the scavenger receptor cysteine-rich domain 5 of CD163 are resistant to PRRSV-1 infection

Christine Burkard, Tanja Opriessnig, Alan J Mileham, Tomasz Stadejek, Tahar Ait-Ali, Simon G Lillico, C Bruce A Whitelaw, Alan L Archibald Journal of Virology 20 Jun 2018

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Introducing genetic resistance for trypanosomiasis into sheep and cattle

J. Raper, R. Zipkin, J. Verdi, S. Suhr, J. Cibelli, C. Schoenherr, A. Economides, D. Frendewey, V. Lai, D. Valenzuela, C. Proudfoot, S. Lillico, B. Ritchie, B. Whitelaw, A. Archibald, M. Y. Yu, S. Kemp Transgenic Research Vol: 25 Pages: 102 2016

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Biosynthesis of Milk Proteins

J. L. Vilotte, Bruce Whitelaw, M. Ollivier-Bousquet, D. B. Shennan 2003

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Producing recombinant human milk proteins in the milk of livestock species

Z. Bosze, M. Baranyi, C. B. A. Whitelaw 2008

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p21(Waf1/Cip1) as a molecular sensor for BoHV-4 replication

A. Capocefalo, V. Franceschi, C. B. A. Whitelaw, D. B. Vasey, S. G. Lillico, S. Cavirani, G. Donofrio Journal of Virological Methods Vol: 161 Pages: 308-311 Nov 2009

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Highly efficient targeted chromosome deletions using CRISPR/Cas9

Zuyong He, Christopher Proudfoot, Alan J. Mileham, David G. Mclaren, C. Bruce A Whitelaw, Simon G. Lillico Biotechnol Bioeng Vol: 112 Pages: 1060-1064 01 Jan 2015

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Insulin-like growth factor binding protein-5 (IGFBP-5) potentially regulates programmed cell death and plasminogen activation in the mammary gland

E Tonner, G Allan, L Shkreta, J Webster, C B Whitelaw, D J Flint Advances in Experimental Medicine and Biology Vol: 480 Pages: 45-53 2000

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Production of germline ablated male pigs via Crispr/Cas editing of the NANOS2 gene

A. Kaucher, K. E. Park, M. Oatley, A. Powell, D. M. Donovan, L. A. Blomberg, S. Lillico, B. Whitelaw, A. Mileham, B. Telugu, J. Oatley Transgenic Research Vol: 25 Pages: 209-210 2016

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Editing myostatin in livestock animals

Rachel Huddart, Chris Proudfoot, Daniel Carlson, Charles Long, Jane Prior, Tim King, Simon Lillico, Alan Mileham, David McLaren, Bruce Whitelaw, Scott Fahrenkrug Transgenic Research Vol: 23 Pages: 867-867 Oct 2014

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Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway

L Y Pang, Thalia Blacking, R W Else, A Sherman, H M Sang, B A Whitelaw, T R Hupp, D J Argyle Veterinary Journal Vol: 196 Pages: 414-423 Jun 2013

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Peroxiredoxin Gene Expression Signatures in Liver Reflect Toxic Insult

Rachel Young, John D. Hayes, Ken Brown, C. Roland Wolf, C. Bruce A. Whitelaw Assay and Drug Development Technologies Vol: 8 Pages: 512-517 Aug 2010

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Enhancing the efficiency of transgene expression

A J Clark, A L Archibald, M McClenaghan, J P Simons, R Wallace, C B Whitelaw Philosophical Transactions of the Royal Society B: Biological Sciences Vol: 339 Pages: 225-32 27 Feb 1993

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Unexpected mutations were expected and unrelated to CRISPR-Cas9 activity

Lluis Montoliu, C Bruce A Whitelaw Transgenic Research Vol: 27 Pages: 315-319 Aug 2018

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An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses

L. Nelson, S. Anderson, A. L. Archibald, S. Rhind, Z. H. Lu, A. Condie, Neil Macintyre, J. Thompson, R. Nenutil, B. Vojtesek, C. B. Whitelaw, T. J. Little, T. Hupp Cell Stress and Chaperones Vol: 13 Pages: 375-385 Sep 2008

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RNA-based biotechnologies: potential future impact on animal health.

Bruce Whitelaw OIE Bulletin Vol: 2 Pages: 15-19 2008

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Multiple copies of beta-lactoglobulin promoter do not function as LCR

R M James, C Neil, J Webster, S Roos, A J Clark, C B Whitelaw Biochemical and Biophysical Research Communications Vol: 272 Pages: 284-9 27 May 2000

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A virus-neutralising antibody is not cytotoxic in vitro

Andreas F Kolb, C Bruce A Whitelaw Molecular Immunology Vol: 43 Pages: 677-89 Feb 2006

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Viral and nonviral vectors

B. Whitelaw Reproduction, Fertility and Development Vol: 25 Pages: 317 2013

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Comment on mosaic nature of G0 transgenic mice.

A.J. Springbett, Tom Burdon, F.E. Yull, Bruce Whitelaw Mouse Genome Vol: 91 Pages: 113 1993

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Duplication of Stat5-binding sites within the beta-lactoglobulin promoter compromises transcription in vivo

Ramona N Pena, C Bruce A Whitelaw Biochimie Vol: 87 Pages: 523-8 Jun 2005

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p21-LacZ reporter mice reflect p53-dependent toxic insult

D. B. Vasey, C. R. Wolf, T. MacArtney, K. Brown, C. B. Whitelaw Toxicology and Applied Pharmacology Vol: 227 Pages: 440-450 Mar 2008

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Position-independent expression of the ovine beta-lactoglobulin gene in transgenic mice

C B Whitelaw, S Harris, M McClenaghan, J P Simons, A J Clark Biochemical Journal Vol: 286 ( Pt 1) Pages: 31-9 15 Aug 1992

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Developing welfare protocols for transgenic large animals

Reinhard Huber, Anna Olsson, Dorte Sorensen, Simon Lillico, Peter Sandoe, Bruce Whitelaw Transgenic Research Vol: 19 Pages: 138-138 Feb 2010

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Genome edited sheep and cattle

Christopher Proudfoot, Daniel F Carlson, Rachel Huddart, Charles R Long, Jane H Pryor, Tim J King, Simon G Lillico, Alan J Mileham, David G McLaren, C Bruce A Whitelaw, Scott C Fahrenkrug Transgenic Research Vol: 24 Pages: 147-153 Feb 2015

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Engineering resilience to African swine fever

M. K. Ballantyne, S. G. Lillico, A. J. Mileham, C. B. Whitelaw Transgenic Research Vol: 25 Pages: 101-102 2016

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Longitudinal changes in telomere length and associated genetic parameters in dairy cattle analysed using random regression models

Luise Seeker, Joanna Warner, Androniki Psifidi, Rachael Wilbourn, Sarah Underwood, Jennifer Fairlie, Rebecca Holland, Ainsley Bagnall, Christopher Whitelaw, Mike Coffey, Daniel Nussey, Georgios Banos PLoS ONE Vol: 13 13 Feb 2018

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Transfection of bovine cell culture with bovine herpesvirus 4 DNA obtained by cell nuclear extraction

G Donofrio, S Cavirani, B Whitelaw, C F Flammini, F Scatozza The new microbiologica Vol: 23 Pages: 129-35 Apr 2000

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Promotion of alleles by genome editing in livestock breeding programmes

John Hickey, Christopher Whitelaw, Gregor Gorjanc Journal of Animal Breeding and Genetics Vol: 133 Pages: 83-84 16 Mar 2016

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The majority of G0 transgenic mice are derived from mosaic embryos

C B Whitelaw, A J Springbett, J Webster, J Clark Transgenic Research Vol: 2 Pages: 29-32 Jan 1993

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Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland

D J Flint, M Boutinaud, E Tonner, C J Wilde, W Hurley, P A Accorsi, A F Kolb, C B A Whitelaw, J Beattie, G J Allan Domestic Animal Endocrinology Vol: 29 Pages: 274-82 Aug 2005

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CRISPR-Based Gene Drives for Pest Control

Gus R. McFarlane, C. Bruce A. Whitelaw, Simon G. Lillico Trends in biotechnology Vol: 36 Pages: 130-133 Feb 2018

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Transgenic Livestock for Food Production, An Introduction to.

Bruce Whitelaw 2012

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Matrix attachment region regulates basal beta-lactoglobulin transgene expression

C B Whitelaw, S Grolli, P Accornero, G Donofrio, E Farini, J Webster Gene Vol: 244 Pages: 73-80 22 Feb 2000

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Gene inactivation and nonmeiotic allele introgression in livestock species using talens

S. C. Fahrenkrug, W. F. Tan, S. G. Lillico, D. Stverakova, C. Proudfoot, G. Williamson, C. R. Long, B. A. Whitelaw, D. F. Carlson Reproduction, Fertility and Development Vol: 25 Pages: 318 2013

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Promoter characterization and functional association with placenta of porcine MAGEL2

Caode Jiang, Yongsheng Yang, Chenchen Huang, Bruce Whitelaw Gene Vol: 547 Pages: 63-69 15 Aug 2014

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The minipig as a platform for new technologies in toxicology

Roy Forster, Philippe Ancian, Merete Fredholm, Henner Simianer, Bruce Whitelaw, RETHINK Project Journal of Pharmacological and Toxicological Methods Vol: 62 Pages: 227-235 2010

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Mammary gland differentiation inversely correlates with GDF-8 expression

R. Manickam, R. N. Pena, C. B. Whitelaw Molecular Reproduction and Development Vol: 75 Pages: 1783-1788 Dec 2008

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CD13/aminopeptidase N is a negative regulator of mast cell activation

J. S. Zotz, F. Wo lbing, C. Lassnig, M. Kauffmann, U. Schulte, A. Kolb, B. Whitelaw, M. Mu ller, T. Biedermann, M. Huber The FASEB Journal Vol: 30 Pages: 2225-2235 02 Mar 2016

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Lentiviral vectors containing mouse Csf1r control elements direct macrophage-restricted expression in multiple species of birds and mammals

Clare Pridans, Simon Lillico, Bruce Whitelaw, David A Hume Molecular Therapy — Methods & Clinical Development Vol: 1 Apr 2014

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C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

Bhuvaneish Thangaraj Selvaraj, Matthew Livesey, Jenna Gregory, Amit Chouhan, Emma Perkins, Owen Dando, Simon Lillico, Navneet Vasistha, Dario Magnani, David Story, Peter Kind, Timothy Aitman, Christopher Whitelaw, Ian Wilmut, Colin Smith, Giles Hardingham, David Wyllie, Siddharthan Chandran and 14 others Nature Communications Vol: 9 Pages: 347 24 Jan 2018

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Disease-resistant genetically modified animals

C B A Whitelaw, H M Sang Revue scientifique et technique-Office international des epizooties Vol: 24 Pages: 275-83 Apr 2005

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Zinc finger nuclease technology heralds a new era in mammalian transgenesis

Fabienne Le Provost, Simon Lillico, Bruno Passet, Rachel Young, Bruce Whitelaw, Jean-Luc Vilotte Trends in biotechnology Vol: 28 Pages: 134-141 Mar 2010

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Illuminating Role of CYP1A1 in Skin Function

J. M. Rowe, C. Welsh, R. N. Pena, C. R. Wolf, K. Brown, C. B. Whitelaw Journal of Investigative Dermatology Vol: 128 Pages: 1866-1868 Jul 2008

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Pharmaceutical proteins in milk from transgenic animals.

Bruce Whitelaw 2001

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Regulatory domains within the P0 promoter of human c-myc

J C Lang, N M Wilkie, A M Clark, A Chudleigh, S Talbot, B Whitelaw, Margaret Frame Oncogene Vol: 6 Pages: 2067-75 Nov 1991

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The changing role of cell culture in the generation of transgenic livestock

C B Whitelaw, E Farini, J Webster Cytotechnology Vol: 31 Pages: 3-8 Sep 1999

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Nonmeiotic introgression of quantitative trait nucleotides and correction of congenital mutations in livestock with transcription activator-like effector nucleases

S. C. Fahrenkrug, W. Tan, S. G. Lillico, D. Stverakova, C. Proudfoot, G. Williamson, C. R. Long, C. B. A. Whitelaw, D. F. Carlson Reproduction, Fertility and Development Vol: 25 Pages: 316 2013

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Tissue-specific and expression of porcine growth hormone gene in BAC transgenic mice

Jia Tong, Simon G Lillico, Ming Jun Bi, Tong Qing, Xiao Fang Liu, Yuanyuan Wang, Min Zheng, Meili Wang, Yun Ping Dai, C Bruce A Whitelaw, Ning Li Transgenic Research Vol: 20 Pages: 933-8 Aug 2011

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Live lambs born from zona-pellucida denuded embryos

William A Ritchie, Jane E Taylor, John O Gardner, Ian Wilmut, Ailsa Carlisle, Claire Neil, Tim King, C Bruce A Whitelaw Cloning and Stem Cells Vol: 7 Pages: 178-82 2005

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Optimisation of transgene expresssion in the mammary gland.

Bruce Whitelaw, A J Clark 1999

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Lentiviral-directed transgenesis in swine is an efficient tool to study human dominant genetic diseases

C. Kostic, N. Grandchamp, T. King, S. Crippa, S. Philippe, S. Lillico, C. Sarkis, J. Mallet, Y. Arsenijevic, B. Whitelaw Human Gene Therapy Vol: 23 Pages: A147-A147 2012

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Generation of functional neurons from feeder-free, keratinocyte-derived equine induced pluripotent stem cells

Ruchi Sharma, Matthew R Livesey, David Ja Wyllie, Christopher Proudfoot, Bruce Whitelaw, David C Hay, Xavier Donadeu Stem Cells and Development Vol: 23 Pages: 1524-1534 18 Feb 2014

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Toward designer milk

B Whitelaw Nature Biotechnology Vol: 17 Pages: 135-6 Feb 1999

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Mammalian interspecies substitution of immune modulatory alleles by genome editing

Simon Lillico, Christopher Proudfoot, Timothy King, Wenfang Tan, Lei Zhang, Rachel Mardjuki, David E. Paschon, Edward J Rebar, Fyodor D Urnov, Alan J Mileham, David G McLaren, Christopher Whitelaw Scientific Reports Vol: 6 22 Feb 2016

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A high resolution atlas of gene expression in the domestic sheep (Ovis aries)

Emily Clark, Stephen Bush, Mary McCulloch, Iseabail Farquhar, Rachel Young, Lucas Lefevre, Clare Pridans, Hiu-gwen Tsang, Chunlei Wu, Cyrus Afrasiabi, Michael Watson, Christopher Whitelaw, Tom Freeman, Kim Summers, Alan Archibald, David Hume PLoS Genetics Vol: 13 15 Sep 2017

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Distal transgene insertion affects CpG island maintenance during differentiation

D. Strathdee, C. B. A. Whitelaw, A. J. Clark Journal of Biological Chemistry Vol: 283 Pages: 11509-11515 Apr 2008

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Spatial p21 expression profile in the mid-term mouse embryo

Douglas B. Vasey, C. Roland Wolf, Ken Brown, C. Bruce A. Whitelaw Transgenic Research Vol: 20 Pages: 23-28 Feb 2011

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Using standard nomenclature to adequately name transgenes, knockout gene alleles and any mutation associated to a genetically modified mouse strain

Lluis Montoliu, C. Bruce A. Whitelaw Transgenic Research Vol: 20 Pages: 435-440 Apr 2011

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Chromatin structure of ß-lactoglobulin transgenes

Bruce Whitelaw 1993

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Chromatin heterogeneity within multicopy transgene arrays

Bruce Whitelaw, John Webster Transgenic Research Vol: 7 Pages: 401-402 01 Jan 1998

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The sheep gene expression atlas project

Emily L. Clark, Iseabail L. Farquhar, Mary B. McCulloch, Stephen J. Bush, C. Bruce Whitelaw, Michael Watson, Kim M. Summers, Alan L. Archibald, David A. Hume 09 Jan 2016

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Transgenic livestock made easy

C Bruce A Whitelaw Trends in biotechnology Vol: 22 Pages: 157-9; discussion 159-60 Apr 2004

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Introduction to Mammalian Genome Special Issue: Genome editing

Lydia Teboul, Yann Hérault, Cynthia Smith, Bruce Whitelaw Mammalian Genome Vol: 28 Pages: 235-236 Aug 2017

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The molecular manipulation of milk composition

A J Clark, S Ali, A L Archibald, H Bessos, P Brown, S Harris, M McClenaghan, C Prowse, J P Simons, C B Whitelaw Mammalian Genome Vol: 31 Pages: 950-5 1989

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After three decades of GE animals: what will the 4th bring?

Bruce Whitelaw Transgenic Research Vol: 23 Pages: 200-201 Feb 2014

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Mammary gland development is delayed in mice deficient for aminopeptidase N

Andreas F Kolb, David Sorrell, Caroline Lassnig, Simon Lillico, Ailsa Carlisle, Claire Neil, Claire Robinson, Mathias Müller, C Bruce A Whitelaw Transgenic Research Vol: 22 Pages: 425-434 2012

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Production of transgenic farm animals by viral vector mediated gene transfer

C. B. A. Whitelaw, Simon Lillico, T. King Reproduction in Domestic Animals Vol: 43 Pages: 355-358 Jul 2008

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Functional Annotation of the Sheep (Ovis aries) Genome

Emily Clark, Stephen Bush, Kim Summers, David Hume, Christopher Whitelaw, Michael Watson, Iseabail Farquhar, Alan Archibald 16 Jan 2017

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Transcriptional regulation of the human c-myc gene

J C Lang, B Whitelaw, S Talbot, N M Wilkie The British journal of cancer. Supplement Vol: 9 Pages: 62-6 Dec 1988

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TALEN-mediated engineering of the porcine genome

M. Ballantyne, S. Lillico, C. Proudfoot, D. Carlson, D. McLaren, A. Mileham, S. Fahrenkrug, B. Whitelaw Transgenic Research Vol: 23 Pages: 202-202 Feb 2014

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Chromatin structures of goat and sheep beta-lactoglobulin gene differ

R N Pena, J M Folch, A Sánchez, C B Whitelaw Biochemical and Biophysical Research Communications Vol: 252 Pages: 649-53 27 Nov 1998

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Transgenic sheep designed for transplantation studies

W. A. Ritchie, T. King, Claire Neil, Ailsa Carlisle, Simon Lillico, G. McLachlan, C. B. Whitelaw Molecular Reproduction and Development Vol: 76 Pages: 61-64 Jan 2009

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Efficient TALEN-mediated gene knockout in livestock

Daniel F Carlson, Spring Tan, Simon G Lillico, Dana Stverakova, Christopher Proudfoot, Michelle Christian, Daniel F Voytas, Charles R Long, C Bruce A Whitelaw, Scott C Fahrenkrug Proceedings of the National Academy of Sciences Vol: 109 Pages: 17382-7 2012

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Development of Germline Manipulation Technologies in Livestock

Bruce Whitelaw 2005

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Dynein light chain 1 (LC8) sequence is highly conserved between pig species

C. J. Palgrave, Z. H. Lu, C. S. Lowden, C. B. A. Whitelaw Animal Genetics Vol: 42 Pages: 337-337 Jun 2011

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Efficient generation of transgenic pigs using equine infectious anaemia virus (EIAV) derived vector

C Bruce A Whitelaw, Pippa A Radcliffe, William A Ritchie, Ailsa Carlisle, Fiona M Ellard, Romi N Pena, Jo Rowe, A John Clark, Tim J King, Kyriacos A Mitrophanous FEBS Letters Vol: 571 Pages: 233-6 30 Jul 2004

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Genetically engineering milk

C Bruce A Whitelaw, Akshay Joshi, Satish Kumar, Simon G Lillico, Christopher Proudfoot Journal of Dairy Research Vol: 83 Pages: 3-11 12 Feb 2016

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Temporal profiles of appearance of DNase I hypersensitive sites associated with the ovine beta-lactoglobulin gene differ in sheep and transgenic mice

C B Whitelaw, J Webster Molecular & general genetics Vol: 257 Pages: 649-54 Apr 1998

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95 production of gene-edited pigs, cattle, and lambs by embryo injection of TALENS or ZFNs

S C Fahrenkrug, S G Lillico, C Proudfoot, T J King, J H Pryor, C R Long, C B A Whitelaw, D F Carlson Reproduction, Fertility and Development Vol: 26 Pages: 161 Dec 2013

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The future of animal production: improving productivity and sustainability

D. A. Hume, C. B. A. Whitelaw, A. L. Archibald Journal of Agricultural Science Vol: 149 Pages: 9-16 2011

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A virus-neutralising monoclonal antibody expressed in the milk of transgenic mice

A F Kolb, J Webster, C B Whitelaw, S G Siddell Advances in Experimental Medicine and Biology Vol: 494 Pages: 411-4 2001

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Transgene methylation in mice reflects copy number but not expression level

Ramona N Pena, John Webster, Stephen Kwan, Jan Korbel, Bruce A Whitelaw Molecular Biotechnology Vol: 26 Pages: 215-20 Mar 2004

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EXPRESSION OF HUMAN ANTI-HEMOPHILIC FACTOR-IX IN THE MILK OF TRANSGENIC SHEEP

A J CLARK, H BESSOS, J O BISHOP, P BROWN, S HARRIS, R LATHE, M MCCLENAGHAN, C PROWSE, J P SIMONS, Bruce Whitelaw, I WILMUT Bio-technology Vol: 7 Pages: 487-492 May 1989

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Large animal models of cardiovascular disease

Hiu-Gwen Tsang, Nabil Rashdan, Christopher Whitelaw, Brendan Corcoran, Kim Summers, Victoria MacRae Cell Biochemistry and Function Vol: 34 Pages: 113–132 24 Feb 2016

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Spatial monitoring of toxicity in HMOX-LacZ transgenic mice

Rachel Young, C. R. Wolf, K. Brown, J. D. Hayes, C. B. A. Whitelaw Transgenic Research Vol: 19 Pages: 897-902 Oct 2010

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CMV enhancer-promoter is preferentially active in exocrine cells in vivo

D B Vasey, S G Lillico, H M Sang, T J King, C B A Whitelaw Transgenic Research Vol: 18 Pages: 309-14 Apr 2009

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Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function

Christine Burkard, Simon Lillico, Elizabeth Reid, Ben Jackson, Alan J. Mileham, Tahar Ait-Ali, Christopher Whitelaw, Alan Archibald Plos pathogens Vol: 13 23 Feb 2017

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On the use of post-transcriptional processing elements in transgenes

C B A Whitelaw, L Hiripi, E Farini, M L Opsahl, Z Bosze Transgenic Research Vol: 13 Pages: 75-9 Feb 2004

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Gene targeting, genome editing: from Dolly to editors

Wenfang Tan, Christopher Proudfoot, Simon Lillico, Christopher Whitelaw Transgenic Research Vol: 25 Pages: 273-287 Jun 2016

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Rescue of an MMTV transgene by co-integration reveals novel locus control properties of the ovine beta-lactoglobulin gene that confer locus commitment to heterogeneous tissues

B Langley, J L Vilotte, M G Stinnakre, C B Whitelaw, P J L'Huillier Transgenic Research Vol: 7 Pages: 205-12 May 1998

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Reprogramming Pig Fetal Fibroblasts Reveals a Functional LIF Signaling Pathway

Alison J Thomson, Hadrien Pierart, Stephen Meek, Alexandra Bogerman, Linda Sutherland, Helen Murray, Edward Mountjoy, Alison Downing, Richard Talbot, Chiara Sartori, C Bruce A Whitelaw, Tom C Freeman, Alan L Archibald, Tom Burdon Cellular Reprogramming Vol: 14 Pages: 112-122 2012

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Toward Ovine iPSCs

C Bruce A Whitelaw Cellular Reprogramming Vol: 15 Pages: 385-8 Oct 2013

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Potential to exploit RNA processing elements in transgenic mice.

Bruce Whitelaw, J Webster, P Kastanis, E Farini, F Osman, R Kaempfer, L Hiripi, S Bosze Cloning and Stem Cells Vol: 3 Pages: 170 2001

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Relative transgene expression frequencies in homozygous versus hemizygous transgenic mice

Su-Ping Chang, Margaret L Opsahl, C Bruce A Whitelaw, Steven D Morley, John D West Transgenic Research Vol: 22 Pages: 1143-1154 Dec 2013

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Multiple effects of genetic background on variegated transgene expression in mice

M L Opsahl, M McClenaghan, A Springbett, S Reid, R Lathe, A Colman, C B A Whitelaw Genetics Vol: 160 Pages: 1107-1112 Mar 2002

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Genome Editing and the Future of Farming meeting report

Monica Hoyos-Flight, Emilie Brady, Helen Sang, Bruce Whitelaw Transgenic Research Vol: 26 Pages: 319-321 Apr 2017

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Precision genetics for complex objectives in animal agriculture

S. C. Fahrenkrug, A. Blake, D. F. Carlson, T. Doran, A. Van Eenennaam, D. Faber, C. Galli, Q. Gao, P. B. Hackett, N. Li, E. A. Maga, W. M. Muir, J. D. Murray, D. Shi, R. Stotish, E. Sullivan, J. F. Taylor, M. Walton, M. Wheeler, B. Whitelaw, B. P. Glenn Journal of Animal Science Vol: 88 Pages: 2530-2539 Jul 2010

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Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene

Ki-Eun Park, Amy V. Kaucher, Anne Powell, Muhamad Salman Waqas, Shelley E.S. Sandmaier, Melissa J. Oatley, Chi-Hun Park, Ahmed Tibary, David M. Donovan, Le Ann Blomberg, Simon Lillico, Christopher Whitelaw, Alan Mileham, Bhanu Telugu, Jon M. Oatley Scientific Reports Vol: 7 10 Jan 2017

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Mono-allelic expression of variegating transgene locus in the mouse

M L Opsahl, A Springbett, R Lathe, A Colman, M McClenaghan, C B A Whitelaw Transgenic Research Vol: 12 Pages: 661-669 Dec 2003

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Evaluation of RNA-knockdown strategies for modulation of cytochrome P450 reductase activity in mouse hepatocytes

Neil C. W. Mackenzie, Simon Lillico, K. Brown, C. R. Wolf, C. B. A. Whitelaw Journal of RNAi and Gene Silencing. Vol: 6 Pages: 416-421 2010

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Methods of gene transfer and their potential use to modify milk composition

I. Wilmut, Alan Archibald, S. Harris, M. Mcclenaghan, J.p. Simons, Bruce Whitelaw, A.j. Clark Theriogenology Vol: 33 Pages: 113-123 01 Jan 1990

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Transgenic mice secreting coronavirus neutralizing antibodies into the milk

I Sola, J Castilla, B Pintado, J M Sánchez-Morgado, C B Whitelaw, A J Clark, L Enjuanes Journal of Virology Vol: 72 Pages: 3762-72 May 1998

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Recombinant protein production in milk.

R Pena, Bruce Whitelaw Biological Sciences Review Vol: 15 Pages: 39-41 2002

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Comparison of surrogate reporter systems for enrichment of cells with mutations induced by genome editors

Zuyong He, Xuan Shi, Meirui Liu, Guangjie Sun, Christopher Proudfoot, Christopher Whitelaw, Simon Lillico, Yaosheng Chen Journal of Biotechnology Vol: 221 Pages: 49-54 10 Mar 2016

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Live pigs produced from genome edited zygotes

Simon Lillico, Christopher Proudfoot, D. F. Carlson, Dana Stverakova, Claire Neil, Carol Blain, Tim King, WA Ritchie, Spring Tan, A Mileham, D Mclaren, Scott C Fahrenkrug, Bruce Whitelaw Scientific Reports Vol: 3 Pages: 1-4 2013

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A future for transgenic livestock

John Clark, Bruce Whitelaw Nature Reviews Genetics Vol: 4 Pages: 825-833 01 Oct 2003

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Characterisation and cardiac directed differentiation of canine adult cardiac stem cells

H.M. Hodgkiss-Geere, David Argyle, Brendan Corcoran, B. Whitelaw, E. Milne, D. Bennett, Sally Argyle Veterinary Journal Vol: 191 Pages: 176-182 2012

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Lentiviral transgenesis in livestock

Simon Lillico, D. Vasey, Tim King, B. Whitelaw Transgenic Research Vol: 20 Pages: 441-442 2011

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Ovine-Induced Pluripotent Stem Cells Can Contribute to Chimeric Lambs

C. Sartori, A.I. Didomenico, A.J. Thomson, E. Milne, S.G. Lillico, T.G. Burdon, C.B. Whitelaw Cellular Reprogramming Vol: 14 Pages: 8-19 2012

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Transgenic constructs with some (but not all) introns.

Alan Archibald, A. J. Clark, S. Harris, M McClenaghan, J. P. Simons, Bruce Whitelaw 1998

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Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs

Serap Gonen, Janez Jenko, Gregor Gorjanc, Alan J Mileham, Christopher Whitelaw, John Hickey Genetics Selection Evolution Vol: 49 04 Jan 2017

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The Genome Editing Revolution in Livestock Marches on

Christopher Whitelaw Human Mutation Vol: 37 Pages: 5 2016

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Does genetic modification violate intrinsic value?

C Bruce A Whitelaw, Donald M Bruce Trends in biotechnology Vol: 20 Pages: 488-9 Dec 2002

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Genetic engineering: Animal cell technology

R M Tywman, Bruce Whitelaw 2000

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Expression of c-myc is down-regulated as mouse mammary epithelial cells become confluent

S Grolli, P Accornero, R Ramoni, G Donofrio, C B Whitelaw Biochemical and Biophysical Research Communications Vol: 239 Pages: 566-9 20 Oct 1997

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Analysis Of Photoreceptor Abnormality In Gucy2d E837D/R838S Transgenic Pigs

Corinne Kostic, Tim King, Sylvain V Crippa, Stephanie Philippe, Simon Lillico, Chamsy Sarkis, Jacques Mallet, Yvan Arsenijevic, Bruce Whitelaw 2012

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Production of pharmaceutical proteins in milk

I. Wilmut, A. L. Archibald, M. Mcclenaghan, J. P. Simons, C. B. A. Whitelaw, A. J. Clark Experientia Vol: 47 Pages: 905-912 01 Sep 1991

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Rapid cohort generation and analysis of disease spectrum of large animal model of cone dystrophy

Corinne Kostic, Simon Geoffrey Lillico, Sylvain Vincent Crippa, Nicolas Grandchamp, Héloïse Pilet, Stéphanie Philippe, Zen Lu, Tim James King, Jacques Mallet, Chamsy Sarkis, Yvan Arsenijevic, Christopher Bruce Alexander Whitelaw PLoS ONE Vol: 8 Pages: e71363 2013

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Method specific calibration corrects for DNA extraction method effects on relative telomere length measurements by quantitative PCR

Luise A Seeker, Rebecca Holland, Sarah Underwood, Jennifer Fairlie, Androniki Psifidi, Joanna Warner, Ainsley Bagnall, Bruce Whitelaw, Mike Coffey, Georgios Banos, Daniel Nussey PLoS ONE Vol: 11 10 Oct 2016

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Strategies for production of pharmaceutical proteins in milk

I Wilmut, C B Whitelaw Reproduction, Fertility and Development Vol: 6 Pages: 625-30 1994

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Expression of ß-lactoglobulin and hybrid transgenes in the mammary gland.

Bruce Whitelaw, Alan Archibald, M McClenaghan, S. Harris, J. P. Simons, C J Watson, Ian Wilmut, A. J. Clark Proc Biotech USA Pages: 130-136 1990

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Strain-specific copy number variation in the intelectin locus on the 129 mouse chromosome 1

Z.H. Lu, A. Di Domenico, S.H. Wright, P.A. Knight, C.B.A. Whitelaw, A.D. Pemberton BMC Genomics Vol: 12 2011

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Mice Transgenic For Human Dominant Mutations Of The GUCY2D Gene

Corinne Kostic, Verene Pignat, Bruce Whitelaw, Heloise Pilet, Suzanne Ursulet, Sebastien Dussaud, Yvan Arsenijevic, Chamsy Sarkis 2011

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Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice

Elizabeth Tonner, Michael C Barber, Gordon J Allan, James Beattie, John Webster, C Bruce A Whitelaw, David J Flint Development Vol: 129 Pages: 4547-57 Oct 2002

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Intronic sequences modulate the sensitivity of beta-lactoglobulin transgenes to position effects

J Webster, G Donofrio, R Wallace, A J Clark, C B Whitelaw Gene Vol: 193 Pages: 239-43 09 Jul 1997

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Animal and cellular models of human disease

Mark Arends, Eric White, Christopher Whitelaw The Journal of Pathology Vol: 238 Pages: 137-140 Jan 2016

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Engineering large animal models of human disease: Domesticated Animal Models of Human Disease

C. Bruce A. Whitelaw, Timothy P. Sheets, Simon G. Lillico, Bhanu P. Telugu The Journal of Pathology Vol: 238 Pages: 247-256 Jan 2016

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The New R: How an Animal Welfare and Ethical Review Body in the UK Is Tackling Reproducibility

Jane Gebbie, Christopher Whitelaw 2016

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Truncated beta-lactoglobulin transgenes are expressed in the kidney

C B Whitelaw Gene Vol: 178 Pages: 157-9 31 Oct 1996

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Animal bioreactors.

Bruce Whitelaw, A. J. Clark AgBiotech News and Information Vol: 1 Pages: 701-705 1989

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Modification of milk composition by gene transfer

J. P. Simons, S. Ali, Alan Archibald, P. Brown, S. Harris, M McClenaghan, Bruce Whitelaw, Ian Wilmut, A. J. Clark 1990

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Multiple effects of genetic background on variegated transgene expression in mice

Margaret L Opsahl, Margaret McClenaghan, Anthea Springbett, Sarah Reid, Richard Lathe, Alan Colman, C Bruce A Whitelaw Genetics Vol: 160 Pages: 1107-12 Mar 2002

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Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice

C B Whitelaw, A L Archibald, S Harris, M McClenaghan, J P Simons, A J Clark Transgenic Research Vol: 1 Pages: 3-13 Dec 1991

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Pigs Transgenic For Human Dominant Mutations Of The GUCY2D Gene

Yvan Arsenijevic, Tim King, Sylvain V Crippa, Simon Lillico, Chamsy Sarkis, Jacques Mallet, Corinne Kostic, Bruce Whitelaw 2011

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Gene targeting of the rat Csf1r locus using homologous recombination in ES cells

K.R. Upton, C. Pridans, S. Meek, L. Sutherland, B. Whitelaw, T. Burdon, D. Hume 2011

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