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Mr Barry Bradford

Mr Barry Bradford

Core Scientist (Research Fellow)

Highlighted Publications

Host PrP glycosylation: a major factor determining the outcome of prion infection

N. L. Tuzi, E. Cancellotti, Herbert Baybutt, L. Blackford, Barry Bradford, Christopher Plinston, A. Coghill, Patricia Hart, Pedro Piccardo, R. M. Barron, J. C. Manson PLoS Biology Vol: 6 Pages: 872-882 Apr 2008

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Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations.

Anna Raper, Derya Ozdemir, Lucas Lefevre, Kathleen Grabert, Evi Wollscheid-Lengeling, Barry Bradford, Zofia Lisowski, Joana Alves, James Glover, Robert Wallace, David Munro, Veronique Miron, Josef Priller, Stephen Jenkins, Giles Hardingham, Neil Mabbott, Peter Hohenstein, David Hume, Clare Pridans and 11 others Nature Communications 19 Jul 2019

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Glycosylation of PrPC determines timing of neuroinvasion and targeting in the brain following transmissible spongiform encephalopathy infection by a peripheral route

E. Cancellotti, Barry Bradford, N. L. Tuzi, R. D. Hickey, Deborah Brown, K. L. Brown, R. M. Barron, Dorothy Kisielewski, Pedro Piccardo, J. C. Manson Journal of Virology Vol: 84 Pages: 3464-75 2010

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Effect of co-infection with a small intestine-restricted helminth pathogen on oral prion disease pathogenesis in mice

Alejandra Sanchez quintero, Barry Bradford, Rick M Maizels, David Donaldson, Neil Mabbott Scientific Reports Vol: 9 30 Apr 2019

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Antigen presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal-associated bacteria

Felipe Melo-Gonzalez, Hana Kammoun, Elza Evren, Emma Dutton, Markella Papadopoulou, Barry Bradford, Ceylan Tanes, Fahmina Fardus-Reid, Jonathan Swann, Kyle Bittinger, Neil Mabbott, Bruce Vallance, Tim Willinger, David Withers, Matthew R Hepworth Journal of Experimental Medicine 27 Feb 2019

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Type I interferon induces CXCL13 to support ectopic germinal center formation

Alice Denton, Silvia Innocentin, Edward Carr, Barry Bradford, Fanny Lafouresse, Neil Mabbott, Urs Mörbe, Burkhard Ludewig, Joanna Groom, Kim Good-Jacobson, Michelle Linterman Journal of Experimental Medicine 05 Feb 2019

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Oral prion neuroinvasion occurs independently of PrPC expression 1 in the gut epithelium

Alison Marshall, Barry Bradford, Alan R Clarke, Jean Manson, Neil Mabbott Journal of Virology Vol: 92 18 Jul 2018

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Increased susceptibility to oral Trichuris muris infection in the specific absence of CXCR5+ CD11c+ cells

Barry Bradford, David Donaldson, Ruth Forman, Kathryn Else, Neil Mabbott Parasite Immunology Vol: 40 Aug 2018

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Prion disease pathogenesis in the absence of the commensal microbiota

Barry Bradford, Laura Tetlow, Neil Mabbott Journal of General Virology Vol: 98 Pages: 1943-1952 15 Jul 2017

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Oral prion disease pathogenesis is impeded in the specific absence of CXCR5-expressing dendritic cells

Barry Bradford, Boris Reizis, Neil Mabbott Journal of Virology Vol: 91 May 2017

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Prion pathogenesis is unaltered following down-regulation of SIGN-R1

Barry Bradford, Karen Brown, Neil Mabbott Virology Vol: 497 Pages: 337-345 Oct 2016

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The good, the bad and the ugly of dendritic cells during prion disease

Neil Mabbott, Barry Bradford Journal of Immunology Research Vol: 2015 Nov 2015

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Reciprocal Regulation of Lymphoid Tissue Development in the Large Intestine by IL-25 and IL-23: Regulation of colonic ILF by IL-25/IL-23

David Donaldson, Barry Bradford, David Artis, Neil Mabbott Mucosal Immunology Vol: 8 Pages: 582-595 May 2015

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Human prion diseases and the risk of their transmission during anatomical dissection

Barry Bradford, Pedro Piccardo, James Ironside, Neil Mabbott Clinical Anatomy Vol: 27 Pages: 821-832 2014

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Pleiotropic effects of extended blockade of CSF1R signaling in adult mice.

Kristin Sauter, Clare Pridans, Anuj Sehgal, Yi Ting Tsai, Barry Bradford, Sobia Raza, Lindsey Moffat, D. J. Gow, Pip Beard, Neil Mabbott, LB Smith, David Hume Journal of Leukocyte Biology Vol: 96 Pages: 265-274 Aug 2014

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Aging and the mucosal immune system in the intestine

Neil Mabbott, Atsushi Kobayashi, Anuj Sehgal, Barry Bradford, Mari Pattison, David Donaldson Biogerontology Vol: 16 Pages: 133-145 Apr 2015

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Peripheral prion disease pathogenesis is unaltered in the absence of sialoadhesin (Siglec-1/CD169)

Barry Bradford, P R Crocker, Neil Mabbott Immunology Vol: 143 Pages: 120–129 Sep 2014

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Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases.

Nadia L. Tuzi, A.R. Clarke, Barry Bradford, L Aitchison, V. Thomson, Jean Manson Genesis Vol: 40 Pages: 1-6 24 Aug 2004

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Prion Disease and the Innate Immune System

Barry Bradford, Neil Mabbott Viruses Vol: 4 Pages: 3389-3419 28 Nov 2012

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Dramatic Reduction of PrPC Level and Glycosylation in Peripheral Nerves following PrP Knock-Out from Schwann Cells Does Not Prevent Transmissible Spongiform Encephalopathy Neuroinvasion

Barry M. Bradford, Nadia L. Tuzi, M. Laura Feltri, Caroline McCorquodale, Enrico Cancellotti, Jean C. Manson Journal of Neuroscience Vol: 29 Pages: 15445-15454 09 Dec 2009

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Follicular Dendritic Cell-Specific Prion Protein (PrP) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen

L. McCulloch, K.L. Brown, B.M. Bradford, J. Hopkins, M. Bailey, K. Rajewsky, J.C. Manson, N.A. Mabbott Plos pathogens Vol: 7 Dec 2011

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Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages

Barry M Bradford, David P Sester, David A Hume, Neil A Mabbott Immunology Vol: 216 Pages: 1228-1237 Nov 2011

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