Dr Vicky MacRae
Reader
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Background
Positions available
PhD studentship opportunities
Projects are available for individuals with self arranged funding, who are able to meet University tuition fees and living expenses through dedicated fellowships and/or private means. Please contact Dr Vicky MacRae (vicky.macrae@roslin.ed.ac.uk) for details.
Qualifications
2001Doctor of Philosophy (PhD), University of Edinburgh, College of Medicine Growth associated and stress-induced myopathies in the domestic chicken (Gallus domesticus)1997Bachelor of Science, University of Edinburgh
Responsibilities & affiliations
The Roslin Institute Seminar Committee
The Roslin Institute Animal Welfare and Ethics Committee
The Bone Research Society Committee
Undergraduate teaching
Cell motility lecture and tutorials in The Animal Body (I) (1st year BVMS)
Supervision of postgraduate, honours and summer student research projects.
Research summary
Investigating new mechanisms of bone formation and vascular calcification.
Current research interests
Our group undertakes research in bone formation and vascular calcification. We examine the mechanisms of differentiation and calcification in growth plate chondrocytes, osteoblasts, vascular smooth muscle cells and valvular interstitial cells. Our research employs transgenic models and clinical samples and utilises use a range of molecular, histological and imaging techniques. The elucidation of new mechanisms of bone formation and vascular calcification may identify new potential therapeutic targets in human and animal disease.-
Bone mineralisation and glucose metabolism.
(14 pages)
In:
Current Opinion in Endocrine and Metabolic Research, vol. 29, pp. 1-15
DOI: https://doi.org/10.1016/j.coemr.2023.100446
Research output: Contribution to Journal › Article (Published) -
TGF-β induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease
(23 pages)
In:
Cell proliferation, pp. 1-23
DOI: https://doi.org/10.1111/cpr.13435
Research output: Contribution to Journal › Article (E-pub ahead of print) -
p53 regulates mitochondrial dynamics in vascular smooth muscle cell calcification.
In:
International Journal of Molecular Sciences, vol. 24
DOI: https://doi.org/10.3390/ijms24021643
Research output: Contribution to Journal › Article (Published) -
Increased PHOSPHO1 and Alkaline Phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery: Control of PHOSPHO1 and TNAP expression by iPTH
In:
Cell Biochemistry and Function, pp. 1-13
DOI: https://doi.org/10.1002/cbf.3772
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor
(14 pages)
In:
Journal of Cellular Physiology, vol. 237, pp. 4303-4316
DOI: https://doi.org/10.1002/jcp.30887
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy
In:
Journal of Endocrinology, vol. 254, pp. 153-167
DOI: https://doi.org/10.1530/JOE-22-0097
Research output: Contribution to Journal › Article (Published) -
Vascular smooth muscle cell fate and vascular remodeling: Mechanisms, therapeutic targets, and drugs, volume I
In:
Frontiers in pharmacology, vol. 13
DOI: https://doi.org/10.3389/fphar.2022.989689
Research output: Contribution to Journal › Editorial (Published) -
The Role of Transforming Growth Factor-β Signaling in Myxomatous Mitral Valve Degeneration
In:
Frontiers in Cardiovascular Medicine, vol. 9
DOI: https://doi.org/10.3389/fcvm.2022.872288
Research output: Contribution to Journal › Review article (Published) -
PALMD regulates aortic valve calcification via altered glycolysis and NF-κB-mediated inflammation
In:
Journal of Biological Chemistry, vol. 298
DOI: https://doi.org/10.1016/j.jbc.2022.101887
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The cardiomyocyte disrupts pyrimidine biosynthesis in non-myocytes to regulate heart repair
In:
Journal of Clinical Investigation
DOI: https://doi.org/10.1172/JCI149711
Research output: Contribution to Journal › Article (E-pub ahead of print)