Professor Tilo Kunath
Group Leader, Chair of Regenerative Neurobiology
- PhD at the University of Toronto with Prof Janet Rossant
- Post-doctoral studies with Prof Austin Smith, Edinburgh
- Visiting professor at the University of Tsukuba
Open to PhD supervision enquiries?
Current PhD students supervised
Yixi Chen (PhD Student)
Ammar Natalwala (Wellcome Trust funded Research Training Fellow and Specialist Registrar in Neurosurgery)
Craig Leighton (PhD Student)
Sophie Glendinning (PhD Student)
Mechanisms of neurodegeneration
Parkinson’s is a progressive neurodegenerative condition that affects millions of people world-wide.
Our lab is focussed in two main areas (i) understanding how the protein, alpha-synuclein, causes degeneration of neurons in Parkinson’s, and (ii) producing a cell-based therapy for Parkinson’s. Central to this aim is generation of midbrain dopaminergic neurons from human pluripotent stem cells. We use patient-derived material to generate induced pluripotent stem cells (iPSCs) with genetic mutations know to cause Parkinson’s.
Aims and areas of interest
The primary aim of the lab is to understand how disease proteins, such as α-synuclein, cause neurodegeneration, and use this understanding to generate novel therapeutics.
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
Nature Communications, vol. 2
Research output: Contribution to Journal › Article (Published)
- Prof Cait MacPhee, School of Physics and Astronomy, University of Edinburgh (https://www.ph.ed.ac.uk/people/cait-macphee)
- Dr Mathew Horrocks, School of Chemistry, University of Edinburgh (http://www.horrockslab.org/)
- Dr Michele Zagnoni, University of Strathclyde, Glasgow (https://www.strath.ac.uk/staff/zagnonimicheledr/)
- Dr J David Beckham, University of Colorado Denver, USA (https://som.ucdenver.edu/Profiles/Faculty/Profile/9071)
- Prof Perdita Barran, University of Manchester