Ted Hupp

Chair of Cancer Research

Background

Ted trained in Chemistry as an undergraduate at Bowling Green State University (Ohio USA) and acquired a PhD in the enzymology of protein-DNA interactions under supervision of Jon Kaguni at Michigan State University (USA). Interests in enzymology was applied to the p53 tumour suppressor protein working with David Lane in Dundee (UK) at the time when the p53 field developed its key concepts including p53’s transcription activation function, p53’s amenability to re-activation by biologics like peptides or monoclonal antibodies, and p53 protein regulation by covalent modifications like ubiquitination, acetylation, and phosphorylation. The Hupp lab is now building on this fundamental knowledge of the p53 pathway to identify dominant pro-oncogenic signals that inactivate p53 in human cancers.

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