Ted Hupp
Chair of Cancer Research
- Cancer Research UK Edinburgh Centre
- MRC Institute of Genetics & Molecular Medicine
Contact details
- Tel: +44 (0)131 651 8500
- Email: Ted.Hupp@ed.ac.uk
Address
- Street
-
Cancer Research UK Edinburgh Centre
MRC Institute of Genetics & Molecular Medicine
The University of Edinburgh
Western General Hospital
Crewe Road South - City
- Edinburgh
- Post code
- EH4 2XR
Background
Ted trained in Chemistry as an undergraduate at Bowling Green State University (Ohio USA) and acquired a PhD in the enzymology of protein-DNA interactions under supervision of Jon Kaguni at Michigan State University (USA). Interests in enzymology was applied to the p53 tumour suppressor protein working with David Lane in Dundee (UK) at the time when the p53 field developed its key concepts including p53’s transcription activation function, p53’s amenability to re-activation by biologics like peptides or monoclonal antibodies, and p53 protein regulation by covalent modifications like ubiquitination, acetylation, and phosphorylation. The Hupp lab is now building on this fundamental knowledge of the p53 pathway to identify dominant pro-oncogenic signals that inactivate p53 in human cancers.
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P-OGC32 Copper-dependent cell death is a cancer specific vulnerability in oesophageal adenocarcinoma and provides the opportunity for future biomarker-stratified clinical trials
In:
British Journal of Surgery, vol. 108
DOI: https://doi.org/10.1093/bjs/znab430.160
Research output: Contribution to Journal › Meeting abstract (Published) -
Kinomics platform using GBM tissue identifies BTK as being associated with higher patient survival
In:
Life Science Alliance
DOI: https://doi.org/10.26508/lsa.202101054
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The role of IFITM proteins in tick-borne encephalitis virus infection
In:
Journal of Virology
DOI: https://doi.org/10.1128/JVI.01130-21
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Structural determinants of peptide-dependent TAP1-TAP2 transit passage targeted by viral proteins and altered by cancer-associated mutations
In:
Computational and Structural Biotechnology Journal
DOI: https://doi.org/10.1016/j.csbj.2021.09.006
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Corrigendum to "Feline mammary carcinoma stem cells are tumorigenic, radioresistant, chemoresistant and defective in activation of the ATM/p53 DNA damage pathway" [The Veterinary Journal 196 (2013) 414-423]
In:
The Veterinary Journal, vol. 276, pp. 105744
DOI: https://doi.org/10.1016/j.tvjl.2021.105744
Research output: Contribution to Journal › Comment/debate (E-pub ahead of print)