Sunniva Bøstrand

Thesis title: Oligodendroglial Dysfunction in Huntington's Disease

Qualifications

MSc Neuroscience, Brasenose College, University of Oxford

BSc (Hons) Psychology 1st Class, The University of Manchester

Research summary

Anna Williams Research Group

Current research interests

I am interested in the cellular heterogeneity of the human nervous system and its role in neuropsychiatric disease. In my PhD research I am focussing on the role of oligodendroglia in Huntington's disease, using high-throughput single nuclear RNA sequencing of post mortem brain tissue combined with bioinformatic approaches in order to better understand how these cell types contribute to disease pathology.
  • Bøstrand SMK, Vaher K, De Nooij L, Harris MA , Cole JH, Cox SR, Marioni RE, McCartney DL, McIntosh AM, Evans KL, Whalley HC, Wootton RE, Clarke T-K (2021): Associations between alcohol use and accelerated biological ageing. Addiction Biology. e13100. https://doi.org/10.1111/adb.13100
  • Bøstrand SMK, Williams A (2021): Oligodendroglial Heterogeneity in Neuropsychiatric Disease. Life. 11(2), 125. https://doi.org/10.3390/life11020125
  • Moyon S, Frawley R, Marechal D, Huang D, Marshall-Phelps KLH, Kegel L, Bøstrand SMK, Sadowski B, Jiang Y-H, Lyons DA, Möbius W, Casaccia P (2021): TET1-mediated DNA hydroxy-methylation regulates adult remyelination. Nature Communications.  12, 3359. https://doi.org/10.1038/s41467-021-23735-3
  • Pokhilko A, Adam E Handel  AE, Curion F, Volpato V, Whiteley ES, Bøstrand SMK, Newey SE, Akerman CJ, Webber C, Clark MB, Bowden R, Cader MZ (2021): Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories. Genome research. https://doi.org/10.1101/gr.273961.120