Sunniva Bøstrand

Thesis title: Oligodendroglial Dysfunction in Huntington's Disease


MSc Neuroscience, Brasenose College, University of Oxford

BSc (Hons) Psychology 1st Class, The University of Manchester

Research summary

Anna Williams Research Group

Current research interests

I am interested in the cellular heterogeneity of the human nervous system and its role in neuropsychiatric disease. In my PhD research I am focussing on the role of oligodendroglia in Huntington's disease, using high-throughput single nuclear RNA sequencing of post mortem brain tissue combined with bioinformatic approaches in order to better understand how these cell types contribute to disease pathology.
  • Bøstrand SMK, Vaher K, De Nooij L, Harris MA , Cole JH, Cox SR, Marioni RE, McCartney DL, McIntosh AM, Evans KL, Whalley HC, Wootton RE, Clarke T-K (2021): Associations between alcohol use and accelerated biological ageing. Addiction Biology. e13100.
  • Bøstrand SMK, Williams A (2021): Oligodendroglial Heterogeneity in Neuropsychiatric Disease. Life. 11(2), 125.
  • Moyon S, Frawley R, Marechal D, Huang D, Marshall-Phelps KLH, Kegel L, Bøstrand SMK, Sadowski B, Jiang Y-H, Lyons DA, Möbius W, Casaccia P (2021): TET1-mediated DNA hydroxy-methylation regulates adult remyelination. Nature Communications.  12, 3359.
  • Pokhilko A, Adam E Handel  AE, Curion F, Volpato V, Whiteley ES, Bøstrand SMK, Newey SE, Akerman CJ, Webber C, Clark MB, Bowden R, Cader MZ (2021): Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories. Genome research.