Dr Shazia Khan (PhD)
Post-doctoral Research Scientist

Address
- Street
-
Queens Medical Research Institute
Edinburgh Bioquarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Background
Research Interests:
- Mass spectrometry imaging (MSI) of tissues and other sample surfaces for targeted and untargeted analysis
- MSI and LCMS based metabolomics and lipidomics for biomarkers discovery
- Understand the role of metabolites & lipids in signaling pathway in disease models using MSI and LCMS/MS
Research Grants and Awards:
- Shazia Khan (2021) Society for Endocrinology Travel Grant (£650) to attend SfE BES Conference, Edinburgh, UK.
- Prof. Gillian Gray, Dr Shazia Khan, Prof. Ruth Andrew (2021/2022) HRUK Novel and Emerging Technologies (NET) Grant (£84727) Project Title: Mass Spectrometry Imaging to Illuminate the activity of 11-hydroxsteroid dehydrogenase-1 inhibitors and their potential for repurposing to prevent the development of heart failure after Myocardial Infarction
- Shazia Khan (2021/2022) Society for Endocrinology Early Career Grant £9995.18. Project Title: Mass Spectrometry Imaging to Map the Neurosteroids Metabolism within the Brain Visit the Society for Endocrinology website
- Shazia Khan (2020/2021) Society for Endocrinology Practical Skills Grant (£2000) Title: Mass Spectrometry Imaging workshop to gain advance practical skills for tissue imaging for endocrinology research. Visit the Society for Endocrinology website
- Shazia Khan (2020/2019) Moray Endowment Fund Award (£2000) Title of project: Developing novel ways to measure estrogens to enhance hormonal screening in clinical research
- Shazia Khan (2020/2019) Biomedical Sciences Honours Project (£400) Determination of estrogens in human plasma by novel derivatising reagent.
- Shazia Khan (2019) Society for Endocrinology Travel Grant (£750) to attend the XXI Lipid Meeting Leipzig, Germany.
- Shazia Khan (2018) Society for Endocrinology Travel Grant (£650) to attend SfE BES Conference, Glasgow, UK.
Qualifications
- Ph.D (Natural Products Chemistry) H.E.J Research Institute of Chemistry, University of Karachi, Pakistan, 2009.
- M.Sc. (Organic Chemistry) First Division, (81%) University of Karachi, Pakistan.
- B.Sc. (Chemistry, Zoology, Botany) First Division, University of Karachi, Pakistan.
Responsibilities & affiliations
- Nature Communications (as mass spectrometry imaging reviewer; ORCID ID: 0000-0003-1738-3418)
- Member of Dutch Society for Mass Spectrometry (2021- present)
- Member of UKRI Early Career Researcher Forum (2020-present)
- Member of Mass Spectrometry Imaging Society (2018-2021)
- Member of SINAPSE – Scottish Imaging Network: A platform for Scientific Excellence (2021-present)
- Member of UK Renal Fibrosis Network (2020-Present)
- Member of European Network for Oxysterol Research (ENOR) (2019- present)
- Member of Society of Endocrinology (2018- present)
- STEM ambassador (2020- present)
- Member of The Royal Society of Edinburgh (2020- present)
- Member of Metabolomics Society (2014)
- Life Time Member, Pakistan Chemical Society (2009-Present).
- Approved PhD Supervisor by HEC (Higher Education Commission) Pakistan (2009-Present)
- HEC Scholar (2004-2008) on “Indigenous Ph.D. Fellowship Program” of the Higher Education Commission of Pakistan.
- STEM ambassador (2020-date)
Teaching / Research Students Supervision activities:
- Associate PhD Supervisor of 2 PhD Students working on mass spectrometry imaging-based projects (2021-Present)
- Lecturing in Membrane Biology course (2021-Present)
- Biomedical Sciences Honours Lab based Project Supervisor (2019)
- Demonstrator (lab tours) of BSc Medical Sciences and CVS Post-Grad Students (2017-Present)
- Supervise PhDs and MSc students in lab for mass spectrometry imaging-based projects (2017-Present)
Undergraduate teaching
- Lecturing in Membrane Biology course (2021-Present)
Postgraduate teaching
Associate PhD Supervisor of 2 PhD Students working on mass spectrometry imaging-based projects (2021-Present)
Open to PhD supervision enquiries?
Yes
Areas of interest for supervision
- Associate PhD Supervisor of 2 PhD Students working on mass spectrometry imaging-based projects (2021-Present)
- Biomedical Sciences Honours Lab based Project Supervisor (2019)
- Demonstrator (lab tours) of BSc Medical Sciences and CVS Post-Grad Students (2017-Present)
- Supervise PhDs and MSc students in lab for mass spectrometry imaging-based projects (2017-Present)
Current PhD students supervised
Sara Al Disi
Monika Selvakumar
Current research interests
• Mass spectrometry imaging (MSI) of tissues and other sample surfaces for targeted and untargeted analysis • MSI and LCMS based metabolomics and lipidomics for biomarkers discovery • Understand the role of metabolites & lipids in signaling pathway in disease models using MSI and LCMS/MSPast research interests
• Bioassays guided natural products isolation, purification, structure elucidation and synthetic modification from different plant sources. • LCMS based metabolomics profiling of different biological samples-
Antimicrobial Volatiles of the Insect Pathogen Metarhizium brunneum
In:
Journal of fungi (Basel, Switzerland), vol. 8
DOI: https://doi.org/10.3390/jof8040326
Research output: Contribution to Journal › Article (Published) -
Derivatization with 2-Hydrazino-1-methylpyridine Enhances Sensitivity of Analysis of 5α-Dihydrotestosterone in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry
In:
Journal of Chromatography A
DOI: https://doi.org/10.1016/j.chroma.2021.461933
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial
In:
The Lancet
DOI: https://doi.org/10.1016/S0140-6736(20)30848-5
Research output: Contribution to Journal › Article (Published) -
MASS SPECTROMETRY IMAGING OF LIPIDS
Research output: › Chapter (Published) -
CHAPTER 5: Mass Spectrometry Imaging of Lipids
(34 pages)
DOI: https://doi.org/10.1039/9781788013109-00088
Research output: › Chapter (Published) -
Current strategies for quantification of estrogens in clinical research
In:
Journal of Steroid Biochemistry and Molecular Biology
DOI: https://doi.org/10.1016/j.jsbmb.2019.04.022
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry
In:
Data in brief
DOI: https://doi.org/10.1016/j.dib.2019.103740
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry
In:
Analytica Chimica Acta
DOI: https://doi.org/10.1016/j.aca.2018.12.023
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Predicting grade and stage at cystoscopy in newly presenting bladder cancersda prospective double-blind clinical study
(2 pages)
In:
The Journal of urology, vol. 202, pp. 457-458
DOI: https://doi.org/10.1016/j.urology.2017.08.007
Research output: Contribution to Journal › Comment/debate (Published) -
Tyrosinase inhibitors from the fruits of Madhuca latifolia
(6 pages)
In:
Current Bioactive Compounds, vol. 10, pp. 31-36
DOI: https://doi.org/10.2174/1573407210666140311234806
Research output: Contribution to Journal › Article (Published) -
Arbutin Derivatives from the Seeds of Madhuca latifolia
(4 pages)
In:
Natural product communications, vol. 6, pp. 1661-1664
Research output: Contribution to Journal › Article (Published) -
Chemical Constituents of Cordia latifolia and Their Nematicidal Activity
(12 pages)
In:
Chemistry and Biodiversity, vol. 8, pp. 850-861
Research output: Contribution to Journal › Article (Published) -
A new isoflavone from the fruits of Madhuca latifolia
(5 pages)
In:
Natural product research, vol. 24, pp. 76-80
DOI: https://doi.org/10.1080/14786410902830100
Research output: Contribution to Journal › Article (Published) -
Chemical constituents of Centella asiatica
(8 pages)
In:
Journal of asian natural products research, vol. 9, pp. 407-414
DOI: https://doi.org/10.1080/10286020600782454
Research output: Contribution to Journal › Article (Published) -
A new triterpenoid, madhunolic acid, from the seeds of Madhuca latifolia
(5 pages)
In:
Journal of asian natural products research, vol. 9, pp. 293-297
DOI: https://doi.org/10.1080/10286020600727442
Research output: Contribution to Journal › Article (Published) -
Two new triterpenoids from Lawsonia alba
(4 pages)
In:
Zeitschrift für Naturforschung B, vol. 60, pp. 37-40
Research output: Contribution to Journal › Article (Published) -
Chemical constituents from the fruits of Madhuca latifolia
(8 pages)
In:
Helvetica Chimica Acta, vol. 87, pp. 1194-1201
Research output: Contribution to Journal › Article (Published) -
Two new and a known compound from Lawsonia inermis
(6 pages)
In:
Helvetica Chimica Acta, vol. 86, pp. 2164-2169
Research output: Contribution to Journal › Article (Published) -
A novel S-nitrosothiol (RIG200) causes prolonged relaxation in dorsal hand veins with damaged endothelium
(7 pages)
In:
Clinical Pharmacology & Therapeutics, vol. 68, pp. 75-81
DOI: https://doi.org/10.1067/mcp.2000.107049
Research output: Contribution to Journal › Article (Published)
Conference details
Selected Posters (award winning & first author only):
- Shazia Khan, J Fallowfield, SP Webster, and R Andrew (2019) Developing Mass Spectrometric Imaging (MSI) Method for Lysophosphatidic Acid (LPA) and Lysophosphatidyl Choline (LPC) in Fibrotic Liver Tissue. XXI Lipid Meeting.
- Shazia Khan and Ruth Andrew (2019) Implementation of Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI-MSI) for Spatial Lipidomics in Brain. 9th ENOR Symposium.
- Shazia Khan and Ruth Andrew (2018) Implementation of Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI-MSI) for Spatial Lipidomics in Brain. Scottish Metabolomics Network Meeting. (Award winning, People Choice)
- Shazia Khan, DF Cobice, DEW Livingstone, A McBride, CL Mackay, BR Walker and R Andrew (2017) Time-dependent Cortisol Turnover in Tissues using Stable Isotope Tracers. Scottish Metabolomics Network Meeting.
- Shazia Khan, DF Cobice, DEW Livingstone, NZM Homer, CL Mackay, BR Walker and R Andrew (2016) Derivatisation Strategies to Quantify Estrogens and Enable Isomer Separation by Ion Mobility. BMSS/BMRC Mass Spectrometry Imaging Symposium
- Shazia Khan, DEW Livingstone, DF Cobice, CL Mackay, BR Walker, NZM Homer and R Andrew (2015) Derivatisation strategies for the analysis of estrogens by ESI and MALDI. Scottish Metabolomics Network Meeting (1st Prize, Judges)
- Shazia Khan, DEW Livingstone, CL Mackay, BR Walker, NZM Homer and R Andrew (2015) Derivatisation Approaches to Quantify Estrogens by LC-MS/MS and in Tissue Sections by MALDI-FTICR-MS. CVS Annual Symposium.
- Shazia Khan, A Sorensen, M Boyed, D Watson (2013) Effect of external beam and 131I-MIBG therapies on Human Glioma cell metabolism. 9th International Conference of the Metabolomics Society. (Poster P3-7)
Invited speaker
- Shazia Khan & Ioannis Stasinopoulos and R Andrew (2021) Corticosteroid localisation in mouse kidney using mass spectrometry imaging, CVS Annual Symposium (Innovative Technology Methods ECR session – SK and IS joint talk, Award winning).
- Shazia Khan, AC Gill, E Claude, M Towers, CL Mackay, BR Walker and R Andrew (2017) Sensitive Detection and Separation of Steroid Isomers following Derivatisation using Ion Mobility. 38th BMSS Annual Meeting (Selected Talk - SK).
- Shazia Khan (2016) Derivatisation of Steroids to Enhance Sensitivity and Isomer Separation. Scottish Metabolomics Network Meeting (Invited Speaker - SK).
- Shazia Khan, E Claude, M Towers, DF Cobice, DEW Livingstone, NZM Homer, CL Mackay, BR Walker and R Andrew (2016) Derivatisation Strategies to Quantify Androgens and Estrogens and Enable Isomer Separation by Ion Mobility. 6th ENOR Symposium (Invited Speaker - RA).
- Mass spectrometry imaging (MSI) of tissues
- MSI based lipidomics and metabolomics for biomarkers discovery
- Understanding the role of lipids, metabolites signaling & pathway in disease models using MSI
- Drugs and inhibitors PK/PD assessment and visualization on tissue specific region of interest by MSI
- STEM clubs for local primary schools (2020)
- Midlothian Science Festival - Heart Explorers Theme 'Feel Good Science Day' (13th October 2019)