Dr Shazia Khan (PhD)

Post-doctoral Research Scientist

  • Centre for Cardiovascular Science

Contact details

Address

Street

Queens Medical Research Institute
Edinburgh Bioquarter
47 Little France Crescent

City
Edinburgh
Post code
EH16 4TJ

Biography

Background

Research Interests:

  • Mass spectrometry imaging (MSI) of tissues and other sample surfaces for targeted and untargeted analysis 
  • MSI and LCMS based metabolomics and lipidomics for biomarkers discovery
  • Understand the role of metabolites & lipids in signaling pathway in disease models using MSI and LCMS/MS

Research Grants and Awards:

  • Shazia Khan (2021) Society for Endocrinology Travel Grant (£650) to attend SfE BES Conference, Edinburgh, UK.
  • Prof. Gillian Gray, Dr Shazia Khan, Prof. Ruth Andrew (2021/2022) HRUK Novel and Emerging Technologies (NET) Grant (£84727) Project Title: Mass Spectrometry Imaging to Illuminate the activity of 11-hydroxsteroid dehydrogenase-1 inhibitors and their potential for repurposing to prevent the development of heart failure after Myocardial Infarction
  • Shazia Khan (2021/2022) Society for Endocrinology Early Career Grant £9995.18. Project Title: Mass Spectrometry Imaging to Map the Neurosteroids Metabolism within the Brain Visit the Society for Endocrinology website 
  • Shazia Khan (2020/2021) Society for Endocrinology Practical Skills Grant (£2000) Title: Mass Spectrometry Imaging workshop to gain advance practical skills for tissue imaging for endocrinology research. Visit the Society for Endocrinology website 
  • Shazia Khan (2020/2019) Moray Endowment Fund Award (£2000) Title of project: Developing novel ways to measure estrogens to enhance hormonal screening in clinical research
  • Shazia Khan (2020/2019) Biomedical Sciences Honours Project (£400) Determination of estrogens in human plasma by novel derivatising reagent.
  • Shazia Khan (2019) Society for Endocrinology Travel Grant (£750) to attend the XXI Lipid Meeting Leipzig, Germany.
  • Shazia Khan (2018) Society for Endocrinology Travel Grant (£650) to attend SfE BES Conference, Glasgow, UK.

Qualifications

  • Ph.D (Natural Products Chemistry) H.E.J Research Institute of Chemistry, University of Karachi, Pakistan, 2009.
  • M.Sc. (Organic Chemistry) First Division, (81%) University of Karachi, Pakistan.
  • B.Sc. (Chemistry, Zoology, Botany) First Division, University of Karachi, Pakistan.

Responsibilities & affiliations

  • Nature Communications (as mass spectrometry imaging reviewer; ORCID ID: 0000-0003-1738-3418)
  • Member of Dutch Society for Mass Spectrometry (2021- present)
  • Member of UKRI Early Career Researcher Forum (2020-present)
  • Member of Mass Spectrometry Imaging Society (2018-2021)
  • Member of SINAPSE – Scottish Imaging Network: A platform for Scientific Excellence (2021-present)
  • Member of UK Renal Fibrosis Network (2020-Present)
  • Member of European Network for Oxysterol Research (ENOR) (2019- present)
  • Member of Society of Endocrinology (2018- present)
  • STEM ambassador (2020- present)
  • Member of The Royal Society of Edinburgh (2020- present)
  • Member of Metabolomics Society (2014)
  • Life Time Member, Pakistan Chemical Society (2009-Present).
  • Approved PhD Supervisor by HEC (Higher Education Commission) Pakistan (2009-Present)
  • HEC Scholar (2004-2008) on “Indigenous Ph.D. Fellowship Program” of the Higher Education Commission of Pakistan.
  • STEM ambassador (2020-date)

Teaching / Research Students Supervision activities:

  • Associate PhD Supervisor of 2 PhD Students working on mass spectrometry imaging-based projects (2021-Present)
  • Lecturing in Membrane Biology course (2021-Present)
  • Biomedical Sciences Honours Lab based Project Supervisor (2019)
  • Demonstrator (lab tours) of BSc Medical Sciences and CVS Post-Grad Students (2017-Present)
  • Supervise PhDs and MSc students in lab for mass spectrometry imaging-based projects (2017-Present)

Undergraduate teaching

  • Lecturing in Membrane Biology course (2021-Present)

Postgraduate teaching

Associate PhD Supervisor of 2 PhD Students working on mass spectrometry imaging-based projects (2021-Present)

Open to PhD supervision enquiries?

Yes

Areas of interest for supervision

  • Associate PhD Supervisor of 2 PhD Students working on mass spectrometry imaging-based projects (2021-Present)
  • Biomedical Sciences Honours Lab based Project Supervisor (2019)
  • Demonstrator (lab tours) of BSc Medical Sciences and CVS Post-Grad Students (2017-Present)
  • Supervise PhDs and MSc students in lab for mass spectrometry imaging-based projects (2017-Present)

Current PhD students supervised

Sara Al Disi

Monika Selvakumar

Current research interests

• Mass spectrometry imaging (MSI) of tissues and other sample surfaces for targeted and untargeted analysis • MSI and LCMS based metabolomics and lipidomics for biomarkers discovery • Understand the role of metabolites & lipids in signaling pathway in disease models using MSI and LCMS/MS

Past research interests

• Bioassays guided natural products isolation, purification, structure elucidation and synthetic modification from different plant sources. • LCMS based metabolomics profiling of different biological samples

View all 19 publications on Research Explorer

Conference details

Selected Posters (award winning & first author only):

  1. Shazia Khan, J Fallowfield, SP Webster, and R Andrew (2019) Developing Mass Spectrometric Imaging (MSI) Method for Lysophosphatidic Acid (LPA) and Lysophosphatidyl Choline (LPC) in Fibrotic Liver Tissue. XXI Lipid Meeting.
  2. Shazia Khan and Ruth Andrew (2019) Implementation of Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI-MSI) for Spatial Lipidomics in Brain. 9th ENOR Symposium.
  3. Shazia Khan and Ruth Andrew (2018) Implementation of Desorption Electrospray Ionisation Mass Spectrometry Imaging (DESI-MSI) for Spatial Lipidomics in Brain. Scottish Metabolomics Network Meeting. (Award winning, People Choice)
  4. Shazia Khan, DF Cobice, DEW Livingstone, A McBride, CL Mackay, BR Walker and R Andrew (2017) Time-dependent Cortisol Turnover in Tissues using Stable Isotope Tracers. Scottish Metabolomics Network Meeting.
  5. Shazia Khan, DF Cobice, DEW Livingstone, NZM Homer, CL Mackay, BR Walker and R Andrew (2016) Derivatisation Strategies to Quantify Estrogens and Enable Isomer Separation by Ion Mobility. BMSS/BMRC Mass Spectrometry Imaging Symposium
  6. Shazia Khan, DEW Livingstone, DF Cobice, CL Mackay, BR Walker, NZM Homer and R Andrew (2015) Derivatisation strategies for the analysis of estrogens by ESI and MALDI. Scottish Metabolomics Network Meeting (1st Prize, Judges)
  7. Shazia Khan, DEW Livingstone, CL Mackay, BR Walker, NZM Homer and R Andrew (2015) Derivatisation Approaches to Quantify Estrogens by LC-MS/MS and in Tissue Sections by MALDI-FTICR-MS. CVS Annual Symposium.
  8. Shazia Khan, A Sorensen, M Boyed, D Watson (2013) Effect of external beam and 131I-MIBG therapies on Human Glioma cell metabolism. 9th International Conference of the Metabolomics Society. (Poster P3-7)

Invited speaker

  1. Shazia Khan & Ioannis Stasinopoulos and R Andrew (2021) Corticosteroid localisation in mouse kidney using mass spectrometry imaging, CVS Annual Symposium (Innovative Technology Methods ECR session – SK and IS joint talk, Award winning).
  2. Shazia Khan, AC Gill, E Claude, M Towers, CL Mackay, BR Walker and R Andrew (2017) Sensitive Detection and Separation of Steroid Isomers following Derivatisation using Ion Mobility. 38th BMSS Annual Meeting (Selected Talk - SK).
  3. Shazia Khan (2016) Derivatisation of Steroids to Enhance Sensitivity and Isomer Separation. Scottish Metabolomics Network Meeting (Invited Speaker - SK).
  4. Shazia Khan, E Claude, M Towers, DF Cobice, DEW Livingstone, NZM Homer, CL Mackay, BR Walker and R Andrew (2016) Derivatisation Strategies to Quantify Androgens and Estrogens and Enable Isomer Separation by Ion Mobility. 6th ENOR Symposium (Invited Speaker - RA).

  • Mass spectrometry imaging (MSI) of tissues
  • MSI based lipidomics and metabolomics for biomarkers discovery
  • Understanding the role of lipids, metabolites signaling & pathway in disease models using MSI
  • Drugs and inhibitors PK/PD assessment and visualization on tissue specific region of interest by MSI

  • STEM clubs for local primary schools (2020)
  • Midlothian Science Festival - Heart Explorers Theme 'Feel Good Science Day' (13th October 2019)
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