Scott Waddell
- MRC Human Genetics Unit
- MRC Institute of Genetics & Molecular Medicine
Contact details
- Email: scott.waddell@ed.ac.uk
Background
I graduated from the University of Glasgow in 2016 with a Bachelor of Science (with First Class Honours) degree in Biochemistry and the University of Edinburgh in 2017 with a Masters of Science in Drug Discovery & Translational Biology. Throughout both these degrees, I developed a strong interest in the molecular mechanisms that drive and the development of therapeutic targets that treat human diseases.
In 2017, I joined the Institute of Genetics & Cancer (IGC, previously Institute of Genetics & Molecular Medicine) on the MRC Human Genetics Unit 4 year PhD programme. I undertook rotational projects studying chromatin dynamics on genome editing (with Dr Andrew Wood) and computational protein biology (with Dr Joe Marsh), and ultimately chose to work alongside Dr Pleasantine Mill & Dr Luke Boulter to understand the role primary cilia play in liver homeostasis and disease. My PhD project focused on understanding the cell and molecular mechanisms underpinning polycystic liver disease after the loss of the cholangiocyte primary cilium.
In 2022, I was awarded an Early Postdoctoral Fellowship from the Chief Scientist Office (Scottish Government) to undertake a 3 year project to understand the role of inflammation in polycystic liver disease.
Qualifications
- PhD Genetics & Molecular Medicine, The University of Edinburgh, 2017-2022
- MSc Drug Discovery & Translational Biology, The University of Edinburgh, 2016-2017
- BSc (Hons) Biochemistry, University of Glasgow, 2012-2016
Project activity
Defining how primary cilia loss drives inflammation in polycystic liver disease
Current project grants
CSO Early Postdoctoral Fellowship (2022-2025)
-
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01
In:
Liver International
DOI: https://doi.org/10.1111/liv.15383
Research output: Contribution to Journal › Article (E-pub ahead of print) -
In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma
(12 pages)
In:
Cancer Research, vol. 82, pp. 1548-1559
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2556
Research output: Contribution to Journal › Article (Published) -
Developing models of cholangiocarcinoma to close the translational gap in cancer research
(12 pages)
In:
Expert opinion on investigational drugs, pp. 1-12
DOI: https://doi.org/10.1080/13543784.2021.1882993
Research output: Contribution to Journal › Review article (Published) -
Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
(13 pages)
In:
Nature Communications, vol. 11
DOI: https://doi.org/10.1038/s41467-020-14283-3
Research output: Contribution to Journal › Article (Published) -
A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice
In:
Developmental Cell, vol. 47, pp. 509-523.e5
DOI: https://doi.org/10.1016/j.devcel.2018.10.027
Research output: Contribution to Journal › Article (Published)