Scott Waddell


I graduated from the University of Glasgow in 2016 with a Bachelor of Science (with First Class Honours) degree in Biochemistry. Throughout my undergraduate degree, I developed a strong interest in the molecular mechanisms that drive human diseases. My Honours project was carried out at the British Heart Foundation Glasgow Cardiovascular Research Centre, and investigated the role of TGF-β signalling in neointima formation of saphenous vein tissues used in coronary artery bypass graft surgery.

I then continued my scientific career at the University of Edinburgh where I attained a Masters of Science in Drug Discovery & Translational Biology. My dissertation project looked at Focal Adhesion Kinase (FAK) as a therapeutic target in ovarian clear cell carcinoma. This project was based at Edinburgh Phenotypic Assay Centre at the Queen’s Medical Research Institute (QMRI).

In 2017, I joined the Institute of Genetics & Molecular Medicine (IGMM) on the MRC Human Genetics Unit 4 year PhD programme. I undertook rotational projects studying chromatin dynamics on genome editing (with Dr Andrew Wood) and computational protein biology (with Dr Joe Marsh); but I ultimately chose to work alongside Dr Pleasantine Mill & Dr Luke Boulter to understand the role primary cilia play in bile duct homeostasis, repair and cancer.


  • MSc Drug Discovery & Translational Biology, The University of Edinburgh, 2016-2017
  • BSc (Hons) Biochemistry, University of Glasgow, 2012-2016

Project activity

Primary cilia project from almost all cell types and function as signalling hubs. These organelles sense extracellular stimuli and are composed of many proteins that function in relaying these signals as cascades towards the cytoplasm and nucleus. My project looks to identify how the characteristics of primary cilia, such as protein composition and associated signalling pathways, change in the bile duct epithelium when in diseased states.


Developing models of cholangiocarcinoma to close the translational gap in cancer research S. H. Waddell, L. Boulter Expert Opinion on Investigational Drugs, vol 


Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

D. H. Wilon et al. Nature Communciations, vol 11


A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice

M. J. Ford & P. L. Yeyati et al. Developmental Cell, vol 47