Scott Waddell
CSO Postdoctoral Research Fellow
- MRC Human Genetics Unit
- Institute of Genetics & Cancer
Contact details
- Email: scott.waddell@ed.ac.uk
Background
Scott Waddell is a CSO Postdoctoral Research Fellow at the MRC Human Genetics Unit. After his undergraduate degree in Biochemistry at the University of Glasgow (2012-2016), Scott completed a Masters in Drug Discovery & Translational Biology at the University of Edinburgh (2016-2017) before obtaining a PhD in Genetics & Molecular Medicine in (2017-2022).
During his PhD, Scott worked with Professor Pleasantine Mill and Dr Luke Boulter to understand the role of the primary cilium in biliary health and disease, focusing on polycystic liver disease (PLD) and cholangiocarcinoma. Following on from his PhD, Scott received a postdoctoral fellowship from the Chief Scientist Office (Scottish Government) to continue his research into PLD, with a particular focus on the role of inflammation in disease.
Qualifications
- PhD Genetics & Molecular Medicine, The University of Edinburgh, 2017-2022
- MSc Drug Discovery & Translational Biology, The University of Edinburgh, 2016-2017
- BSc (Hons) Biochemistry, University of Glasgow, 2012-2016
Undergraduate teaching
- Biology of Regeneration (DEBI10032)
Research summary
- Inflammation in polycystic liver disease
- The role of the primary cilium in bile duct development, disease and cancer
Project activity
Defining how primary cilia loss drives inflammation in polycystic liver disease
Current project grants
CSO Early Postdoctoral Fellowship (2022-2025)
-
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01
In:
Liver International
DOI: https://doi.org/10.1111/liv.15383
Research output: Contribution to Journal › Article (E-pub ahead of print) -
In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma
(12 pages)
In:
Cancer Research, vol. 82, pp. 1548-1559
DOI: https://doi.org/10.1158/0008-5472.CAN-21-2556
Research output: Contribution to Journal › Article (Published) -
Developing models of cholangiocarcinoma to close the translational gap in cancer research
(12 pages)
In:
Expert opinion on investigational drugs, pp. 1-12
DOI: https://doi.org/10.1080/13543784.2021.1882993
Research output: Contribution to Journal › Review article (Published) -
Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
(13 pages)
In:
Nature Communications, vol. 11
DOI: https://doi.org/10.1038/s41467-020-14283-3
Research output: Contribution to Journal › Article (Published) -
A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice
In:
Developmental Cell, vol. 47, pp. 509-523.e5
DOI: https://doi.org/10.1016/j.devcel.2018.10.027
Research output: Contribution to Journal › Article (Published)