Sarah McGlasson (PhD)
Postdoctoral scientist
- Centre for Clinical Brain Sciences
- UK Dementia Research Institute
- Institute for Genetics and Molecular Medicine
Contact details
- Tel: 01312426348
- Email: Sarah.McGlasson@igmm.ed.ac.uk
- Twitter profile
Address
- Street
-
UK DRI, Chancellor's Building
Little France Crescent - City
- Edinburgh
- Post code
- EH16 4SB
Background
I am a postdoctoral researcher in Dr David Hunt's lab based in the UK Dementia Research Institute. My research question is 'How does innate immune activation affect the brain?'. The aim is to understand how this is relevant in diseases of chronic inflammation with neurological dysfunction, including rare monogenic disease and complex autoimmune disease. Identifying the cellular targets of pathogenic inflammation in the brain may lead to a better understanding of how to treat or prevent immune-mediated neurological disease.
Qualifications
PhD, BSc
Responsibilities & affiliations
UK Dementia Research Institute (UK DRI), Centre for Clinical Brain Sciences (CCBS), Institute of Genetics and Molecular Medicine (IGMM)
BSI neuroinflammation affinity group (member)
Chancellor's Building GM safety committee (deputy chair)
-
Neuromyelitis optica in patients with increased interferon alpha concentrations
In:
Lancet Neurology, vol. 19, pp. 31-33
DOI: https://doi.org/10.1016/S1474-4422(19)30445-4
Research output: Contribution to Journal › Letter (Published) -
Cerebrospinal fluid neurofilament light chain in multiple sclerosis and its subtypes: a meta-analysis of case–control studies
In:
Journal of Neurology, Neurosurgery & Psychiatry
DOI: https://doi.org/10.1136/jnnp-2018-319190
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Neurological Disease in Lupus: Toward a Personalized Medicine Approach
In:
Frontiers in Immunology, vol. 9
DOI: https://doi.org/10.3389/fimmu.2018.01146
Research output: Contribution to Journal › Review article (Published) -
Rare variants of the 3’-5’ DNA exonuclease TREX1 in early onset small vessel stroke
In:
Wellcome Open Research , vol. 2, pp. 106
DOI: https://doi.org/10.12688/wellcomeopenres.12631.1
Research output: Contribution to Journal › Article (Published) -
Neuroinflammation: Synapses pruned in lupus
In:
Nature
DOI: https://doi.org/10.1038/nature23087
Research output: Contribution to Journal › Comment/debate (Published) -
Detection of interferon alpha protein reveals differential levels and cellular sources in disease
In:
Journal of Experimental Medicine, vol. 214, pp. 1547-1555
DOI: https://doi.org/10.1084/jem.20161451
Research output: Contribution to Journal › Article (Published) -
Human β-defensin 3 increases the TLR9-dependent response to bacterial DNA
In:
European Journal of Immunology, vol. 47
DOI: https://doi.org/10.1002/eji.201646799
Research output: Contribution to Journal › Article (Published) -
Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature
(10 pages)
In:
Blood, vol. 128, pp. 2824–2833
DOI: https://doi.org/10.1182/blood-2016-05-715987
Research output: Contribution to Journal › Article (Published) -
TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism
(8 pages)
In:
Nature Genetics, vol. 48, pp. 36-43
DOI: https://doi.org/10.1038/ng.3451
Research output: Contribution to Journal › Article (Published) -
Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid
In:
PLoS Genetics, vol. 11
DOI: https://doi.org/10.1371/journal.pgen.1005673
Research output: Contribution to Journal › Article (Published) -
Type I interferon dysregulation and neurological disease
(9 pages)
In:
Nature Reviews Neurology, vol. 11, pp. 515-23
DOI: https://doi.org/10.1038/nrneurol.2015.143
Research output: Contribution to Journal › Literature review (Published)