Sara Knott
- Institute of Evolutionary Biology
- School of Biological Sciences
Contact details
- Tel: +44 (0)131 650 5444
- Email: s.knott@ed.ac.uk
- Web: Group website
Address
- Street
-
Rm. 135, Ashworth Laboratories
Charlotte Auerbach Road - City
- Edinburgh
- Post code
- EH9 3FL
Background
1986 - 1990 Ph.D., University of Edinburgh (at the AFRC Institute of Animal Physiology and Genetics Research)
1990 - 1996 Postdoctoral researcher, University of Edinburgh
1996 - 2006 Royal Society University Research Fellow, University of Edinburgh
2005 - 2010 RCUK Fellow, University of Edinburgh
2007 - present Reader, Institute of Evolutionary Biology, University of Edinburgh
Undergraduate teaching
Course organiser for Genomes and Genomics (third year)
Postgraduate teaching
Programme Director for MSc Animal Breeding and Genetics and on the teaching committee for the MSc Quantitative Genetics suite of programmes.
Course organiser for Linkage and Association in Genome Analysis
Open to PhD supervision enquiries?
Yes
Current PhD students supervised
Caelinn James Investigating the genetic architecture of complex traits in Soay sheep (Principal supervisor)
Eilidh Fummey Exploiting large-scale exome sequence data to determine the genetic control of healthy aging (Assistant supervisor)
Michael Barker Investigating the mechanisms underlying disease using multiOmics data( Assistant supervisor)
Silvia Shen Harnessing genome characterisation to uncover disease mechanisms (Principal supervisor)
Past PhD students supervised
Francesc Ganau Penella (2019-2020) Detecting local positive selection in human phenotypes: the adaptive nature of disease (MScR) (Principal supervisor)
Richard Oppong (2015-2019) Investigating the genetic control of complex traits (Principal supervisor)
Olivia Swann (2012-2018) The Role of the Swain-Langley and McCoy Polymorphisms in Complement Receptor 1 in Cerebal Malaria (Assistant supervisor)
Neil Clelland (2011-2015) Use of computed tomography based predictors of meat quality in sheep breeding programmes (Assistant supervisor)
Claire Donaldson (2010-2015) Spine characteristics in sheep: metrology, relationship to meat yield and their genetic parameters (Principal supervisor)
Gibran Hemani (2007-2011) Dissecting genetic interactions in complex traits (Assistant supervisor)
Richard Leach (2007-2011) Genetics of bovine vaccination (Assistant supervisor)
Baitsi Podisi (2007-2011) Quantitative trait locus mapping of sexual maturity traits applied to chicken breeding (Assistant supervisor)
Ariel Lui (2007-2011) The impact of selection on the diversity of background genome (Assistant supervisor)
Christopher Franklin (2006-2010) Linkage and Association Mapping for Quantitative Phenotype in Isolated Populations (Assistant supervisor)
James Floyd (2006-2010) Analysis of high-density SNP data from complex populations (Assistant supervisor)
Joseph Powell (2006-2009) Influence of genomic architecture on the performance of association mapping: application to ascites syndrome in broiler chickens (Assistant supervisor)
Georgia Hadjipavlou (2006-2009) Detection and characterisation of quantitative trait loci affecting muscle and growth phenotypes in sheep (Assistant supervisor)
Claudia Cabrera (2005-2009) Bioinformatics tools for the genetic dissection of complex traits in chickens (Assistant supervisor)
Suzanne Rowe (2004-2009) QTL mapping technology using variance components in general pedigrees applied to the poultry industry (Assistant supervisor)
Craig Lewis (2006-2008) (Assistant supervisor)
Alex Lam (2005-2008) Design and analysis of genetical genomics studies and their potential applications in livestock research (Assistant supervisor)
Albert Tenesa (2000-2004) Populatio -wide linkage disequilibrium and its uses in QTL mapping and estimation of ancestral population size (Assistant supervisor)
Stuart Macgregor (2000-2003) Genetic linkage mapping in complex pedigrees (Assistant supervisor)
Victor Martinez (1999-2002) Quantitative genetic analysis using molecular markers with applications to fish populations (Principal supervisor)
Research summary
http://knott.bio.ed.ac.uk/research
I'm interested in understanding the genetic control of complex traits that underpin variation of medical, evolutionary and commercial relevance. Almost all traits of importance are complex and influenced by the actions and interactions of many genes and environmental factors. With dense SNP genotypes or sequence data we can dissect this variation and investigate how individual genes act and interact with each other and the environment.
Research activities
-
The impact of SNP density on quantitative genetic analyses of body size traits in a wild population of Soay sheep
(15 pages)
In:
Ecology and Evolution, vol. 12
DOI: https://doi.org/10.1002/ece3.9639
Research output: Contribution to Journal › Article (Published) -
SNP and Haplotype Regional Heritability Mapping (SNHap-RHM): Joint Mapping of Common and Rare Variation Affecting Complex Traits
In:
Frontiers in genetics, vol. 12
DOI: https://doi.org/10.3389/fgene.2021.791712
Research output: Contribution to Journal › Article (Published) -
Prediction of intramuscular fat content and shear force in Texel lamb loins using combinations of different X-ray computed tomography (CT) scanning techniques
(8 pages)
In:
Meat Science, vol. 140, pp. 78-85
DOI: https://doi.org/10.1016/j.meatsci.2018.03.003
Research output: Contribution to Journal › Article (Published) -
Haplotype heritability mapping method uncovers missing heritability of complex traits
(9 pages)
In:
Scientific Reports, vol. 8, pp. 1-9
DOI: https://doi.org/10.1038/s41598-018-23307-4
Research output: Contribution to Journal › Article (Published) -
Regional heritability mapping method helps explain missing heritability of blood lipid traits in isolated populations
(6 pages)
In:
Heredity, vol. 116, pp. 333–338
DOI: https://doi.org/10.1038/hdy.2015.107
Research output: Contribution to Journal › Article (Published) -
Variation and covariation in strongyle infection in East African shorthorn zebu calves.
(13 pages)
In:
Parasitology, vol. 142, pp. 499-511
DOI: https://doi.org/10.1017/S0031182014001498
Research output: Contribution to Journal › Article (Published) -
Corrigendum to 'Prediction of intramuscular fat levels in Texel lamb loins using X-ray computed tomography scanning' [Meat Science 98/2 (2014) 263-271]
In:
Meat Science
DOI: https://doi.org/10.1016/j.meatsci.2015.03.003
Research output: Contribution to Journal › Article (Published) -
Prediction of intramuscular fat levels in Texel lamb loins using X-ray computed tomography scanning
(9 pages)
In:
Meat Science, vol. 98, pp. 263-271
DOI: https://doi.org/10.1016/j.meatsci.2014.06.004
Research output: Contribution to Journal › Article (Published) -
Effect of the Texel muscling QTL (TM-QTL) on spine characteristics in purebred Texel lambs
In:
Small Ruminant Research, vol. 117, pp. 34-40
DOI: https://doi.org/10.1016/j.smallrumres.2013.11.020
Research output: Contribution to Journal › Article (Published) -
Using Haplotype Mapping to Uncover the Missing Heritability: A Simulation Study
Research output: › Conference contribution (Unpublished) -
Genetic linkage analysis identifies Pas1 as the common locus modulating lung tumorigenesis and acute inflammatory response in mice
(6 pages)
In:
Genes and Immunity, vol. 14, pp. 512-517
DOI: https://doi.org/10.1038/gene.2013.49
Research output: Contribution to Journal › Article (Published) -
Comparative analysis of quantitative trait loci for body weight, growth rate and growth curve parameters from 3 to 72 weeks of age in female chickens of a broiler-layer cross
(11 pages)
In:
BMC Genetics, vol. 14
DOI: https://doi.org/10.1186/1471-2156-14-22
Research output: Contribution to Journal › Article (Published) -
Between- and within-breed variations of spine characteristics in sheep
(10 pages)
In:
Journal of Animal Science, vol. 91, pp. 995-1004
DOI: https://doi.org/10.2527/jas.2012-5456
Research output: Contribution to Journal › Article (Published) -
An Evolutionary Perspective on Epistasis and the Missing Heritability
In:
PLoS Genetics, vol. 9
DOI: https://doi.org/10.1371/journal.pgen.1003295
Research output: Contribution to Journal › Article (Published) -
CloudQTL: Evolving a bioinformatics application into the clouds
Research output: Contribution to Conference › Abstract (Published) -
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene
(6 pages)
In:
Obesity, vol. 18, pp. 803-8
DOI: https://doi.org/10.1038/oby.2009.359
Research output: Contribution to Journal › Article (Published) -
Genome-wide analysis of epistasis in body mass index using multiple human populations
(6 pages)
In:
European Journal of Human Genetics, vol. 20, pp. 857-62
DOI: https://doi.org/10.1038/ejhg.2012.17
Research output: Contribution to Journal › Article (Published) -
Complex traits analysis of chicken growth using targeted genetical genomics
(9 pages)
In:
Animal Genetics, vol. 43, pp. 163-71
DOI: https://doi.org/10.1111/j.1365-2052.2011.02223.x
Research output: Contribution to Journal › Article (Published) -
Optimal use of regression models in genome-wide association studies
(11 pages)
In:
Animal Genetics, vol. 43, pp. 133-43
DOI: https://doi.org/10.1111/j.1365-2052.2011.02234.x
Research output: Contribution to Journal › Article (Published) -
Bone mineral density QTL at sexual maturity and end of lay
(7 pages)
In:
British Poultry Science, vol. 53, pp. 763-9
DOI: https://doi.org/10.1080/00071668.2012.747674
Research output: Contribution to Journal › Article (Published)