Ruth Andrew (BSc, PhD)
Personal Chair of Pharmaceutical Endocrinology
Address
- Street
-
The Queen's Medical Research Institute,
Edinburgh BioQuarter,
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My research interests are in steroid biochemistry and applied mass spectrometry. I study glucocorticoids and their actions on fuel metabolsim and inflammation. I have a particular interest in 5alpha-reduced glucocorticoids as potential dissociated glucorticoid receptor modulators. My other area is in the application of mass spectrometry to enable tracking of steroid metabolism, using stable-isotope tracers and also advanced methods of MS detection e.g. imaging.
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Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry
In:
Data in brief
DOI: https://doi.org/10.1016/j.dib.2019.103740
Contribution to journal › Article (E-pub ahead of print) -
Higher Insulin Resistance & Adiposity in Post-menopausal Women With Breast Cancer Treated With Aromatase Inhibitors
In:
Journal of Clinical Endocrinology & Metabolism
Contribution to journal › Article (Published) -
Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways
In:
PLoS One, vol. 13, no. 2, pp. e0192746
DOI: https://doi.org/10.1371/journal.pone.0192746
Contribution to journal › Article (Published) -
Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice
In:
Biochemical Pharmacology, vol. 148, pp. 88-99
DOI: https://doi.org/10.1016/j.bcp.2017.12.013
Contribution to journal › Article (Published) -
Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry
In:
Analytica Chimica Acta
DOI: https://doi.org/10.1016/j.aca.2018.12.023
Contribution to journal › Article (E-pub ahead of print) -
Pulsatility of Glucocorticoid Hormones in Pregnancy: Changes with Gestation and Obesity
In:
Clinical Endocrinology
DOI: https://doi.org/10.1111/cen.13548
Contribution to journal › Article (E-pub ahead of print) -
Non-uniform relationship between salt status and aldosterone activity in patients with chronic kidney disease
In:
Clinical Science, vol. 132, no. 2
DOI: https://doi.org/10.1042/CS20171603
Contribution to journal › Article (E-pub ahead of print) -
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity
In:
Scientific Reports, vol. 7, no. 1, pp. 10633
DOI: https://doi.org/10.1038/s41598-017-10410-1
Contribution to journal › Article (Published) -
Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-017-10200-9
Contribution to journal › Article (E-pub ahead of print) -
Glucocorticoids are lower at delivery in maternal, but not cord blood of obese pregnancies
In:
Scientific Reports, vol. 7
DOI: https://doi.org/10.1038/s41598-017-10266-5
Contribution to journal › Article (E-pub ahead of print) -
Selection and early clinical evaluation of the brain-penetrant 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor UE2343 (Xanamem™)
In:
British Journal of Pharmacology
DOI: https://doi.org/10.1111/bph.13699
Contribution to journal › Article (Published) -
Acute physiological effects of glucocorticoids on fuel metabolism in humans are permissive but not direct
In:
Diabetes Obesity & Metabolism
DOI: https://doi.org/10.1111/dom.12899
Contribution to journal › Article (E-pub ahead of print) -
Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia
In:
Scientific Reports, vol. 7, no. 1, pp. 17092
DOI: https://doi.org/10.1038/s41598-017-17220-5
Contribution to journal › Article (Published) -
Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis
In:
Analytical Biochemistry, vol. 538
DOI: https://doi.org/10.1016/j.ab.2017.09.002
Contribution to journal › Article (Published) -
Transfer and metabolism of cortisol by the isolated perfused human placenta
In:
Journal of Clinical Endocrinology & Metabolism
DOI: https://doi.org/10.1210/jc.2017-02140
Contribution to journal › Article (E-pub ahead of print) -
Safer topical treatment for inflammation using 5α-tetrahydrocorticosterone in mouse models
In:
Biochemical Pharmacology, vol. 129, pp. 73-84
DOI: https://doi.org/10.1016/j.bcp.2017.01.008
Contribution to journal › Article (E-pub ahead of print) -
Metabolic dysfunction in female mice with disruption of 5α-reductase 1
In:
Journal of Endocrinology, vol. 232, no. 1, pp. 29-36
DOI: https://doi.org/10.1530/JOE-16-0125
Contribution to journal › Article (Published) -
Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging
In:
Analytical Chemistry, vol. 88, no. 21
DOI: https://doi.org/10.1021/acs.analchem.6b02242
Contribution to journal › Article (E-pub ahead of print) -
Does metformin reduce excess birthweight in offspring of obese pregnant women? A randomised controlled trial of efficacy, exploration of mechanisms and evaluation of other pregnancy complications
In:
Efficacy and Mechanism Evaluation, vol. 3, no. 7
DOI: https://doi.org/10.3310/eme03070
Contribution to journal › Article (Published) -
ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone; a rationale for safer glucocorticoid replacement therapy
In:
Science translational medicine, vol. 8, no. 352
DOI: https://doi.org/10.1126/scitranslmed.aaf9074
Contribution to journal › Article (Published)