Ruth Andrew (BSc, PhD, MRPharmS)
Personal Chair of Pharmaceutical Endocrinology
Address
- Street
-
The Queen's Medical Research Institute,
Edinburgh BioQuarter,
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Background
Ruth Andrew graduated as a pharmacist from the University of Strathclyde, Glasgow, UK in 1989 and carried out her PhD in pharmaceutical analysis using GC-MS to study synthesis and metabolism of adrenal medullary hormones in hypertensive subjects. She gained a lectureship in the University of Edinburgh in 1994 and was awarded a Chair in Pharmaceutical Endocrinology in 2015. She specialises in understanding regulation of glucocorticoid action in metabolic and inflammatory diseases and has developed innovative tools to study steroid metabolism and flux in vivo, most recently by mass spectrometry imaging. She also is the Director of the Mass Spectrometry Core of the Edinburgh Clinical Research Facility; this laboratory supports a broad spectrum support for clinical researchers requiring small molecule analysis in their research programmes, including studies of toxicology, drug discovery, experimental physiology and pathology. She plays an active role in undergraduate and post-graduate teaching in Endocrine Pharmacology.
Qualifications
BSc Hons First Class Pharmacy (specialisation Pharmaceutical Chemistry)
PhD Pharmaceutical Chemistry
MRPharmS
Post-graduate Certificate in Higher Education
Responsibilities & affiliations
Director, Edinburgh Clinical Research Facility, Mass Spectrometry Core
Society for Endocrinology Trustee, Council Member and Finance Committee Member
Scottish Metabolomics Network, Treasurer
European Oxysterol Research Network Scientific Board
British Journal of Pharmacology Editor
Frontiers in Endocrinology, Specialty Chief Editor, Systems Endocrinology
Chair Seminar Committee, Centre for Cardiovascular Science.
Undergraduate teaching
Endocrine Physiology and Pharmacology, Honours Biomedical Sciences, Deputy Course Organiser
Contributing Lecturer, Y3 BSc Clinical Biochemistry and Endocrinology
Postgraduate teaching
Centre for Cardiovascular Science Post-graduate Committee Member
University Post-graduate Appeals Committee Member
Contributing Lecturer, MSc Cardiovascular Biology
External Lecturer,MSc Pharmaceutical Analysis, University of Strathclyde
Open to PhD supervision enquiries?
Yes
-
Urinary estrogens as a non-invasive biomarker of viable pregnancy in the giant panda (Ailuropoda melanoleuca)
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-019-49288-6
Contribution to journal › Article (Published) -
Simultaneous quantification of estrogens and glucocorticoids in human adipose tissue by liquid-chromatography-tandem mass spectrometry
In:
The Journal of Steroid Biochemistry and Molecular Biology, pp. 105476
DOI: https://doi.org/10.1016/j.jsbmb.2019.105476
Contribution to journal › Article (Published) -
Role of hepatic glucocorticoid receptor in metabolism in models of 5αR1 Deficiency in Male Mice
In:
Endocrinology
DOI: https://doi.org/10.1210/en.2019-00236
Contribution to journal › Article (Published) -
Current strategies for quantification of estrogens in clinical research
In:
The Journal of Steroid Biochemistry and Molecular Biology
DOI: https://doi.org/10.1016/j.jsbmb.2019.04.022
Contribution to journal › Article (E-pub ahead of print) -
Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors: population based cohort study
In:
BMJ
DOI: https://doi.org/10.1136/bmj.l1204
Contribution to journal › Article (Published) -
Data for analysis of catechol estrogen metabolites in human plasma by liquid chromatography tandem mass spectrometry
In:
Data in brief
DOI: https://doi.org/10.1016/j.dib.2019.103740
Contribution to journal › Article (E-pub ahead of print) -
Higher Insulin Resistance and Adiposity in Postmenopausal Women With Breast Cancer Treated With Aromatase Inhibitors
In:
Journal of Clinical Endocrinology & Metabolism, vol. 104, no. 9, pp. 3670-3678
DOI: https://doi.org/10.1210/jc.2018-02339
Contribution to journal › Article (E-pub ahead of print) -
PIPIN : A Feasibility Trial of Pravastatin for the Prevention of Preterm Birth in Women Trial Methods and Protocol.
(1 page)
In:
Reproductive Sciences, vol. 26, pp. 320A-320A
Contribution to journal › Meeting abstract (Published) -
Heritability of cortisol production and metabolism throughout adolescence: a twin study
In:
Journal of Clinical Endocrinology & Metabolism
DOI: https://doi.org/10.1210/clinem/dgz016
Contribution to journal › Article (Published) -
Species-specific regulation of angiogenesis by glucocorticoids reveals contrasting effects on inflammatory and angiogenic pathways
In:
PLoS ONE, vol. 13, no. 2, pp. e0192746
DOI: https://doi.org/10.1371/journal.pone.0192746
Contribution to journal › Article (Published) -
Quantification of 11β-hydroxysteroid dehydrogenase 1 kinetics and pharmacodynamic effects of inhibitors in brain using mass spectrometry imaging and stable-isotope tracers in mice
In:
Biochemical Pharmacology, vol. 148, pp. 88-99
DOI: https://doi.org/10.1016/j.bcp.2017.12.013
Contribution to journal › Article (Published) -
Derivatization enhances analysis of estrogens and their bioactive metabolites in human plasma by liquid chromatography tandem mass spectrometry
In:
Analytica Chimica Acta
DOI: https://doi.org/10.1016/j.aca.2018.12.023
Contribution to journal › Article (E-pub ahead of print) -
Pulsatility of Glucocorticoid Hormones in Pregnancy: Changes with Gestation and Obesity
In:
Clinical Endocrinology
DOI: https://doi.org/10.1111/cen.13548
Contribution to journal › Article (E-pub ahead of print) -
Non-uniform relationship between salt status and aldosterone activity in patients with chronic kidney disease
In:
Clinical science, vol. 132, no. 2
DOI: https://doi.org/10.1042/CS20171603
Contribution to journal › Article (E-pub ahead of print) -
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity
In:
Scientific Reports, vol. 7, no. 1, pp. 10633
DOI: https://doi.org/10.1038/s41598-017-10410-1
Contribution to journal › Article (Published) -
Acute interaction between hydrocortisone and insulin alters the plasma metabolome in humans
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-017-10200-9
Contribution to journal › Article (E-pub ahead of print) -
Glucocorticoids are lower at delivery in maternal, but not cord blood of obese pregnancies
In:
Scientific Reports, vol. 7
DOI: https://doi.org/10.1038/s41598-017-10266-5
Contribution to journal › Article (E-pub ahead of print) -
Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia
In:
Scientific Reports, vol. 7, no. 1, pp. 17092
DOI: https://doi.org/10.1038/s41598-017-17220-5
Contribution to journal › Article (Published) -
Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis
In:
Analytical Biochemistry, vol. 538
DOI: https://doi.org/10.1016/j.ab.2017.09.002
Contribution to journal › Article (Published) -
Transfer and metabolism of cortisol by the isolated perfused human placenta
In:
Journal of Clinical Endocrinology & Metabolism
DOI: https://doi.org/10.1210/jc.2017-02140
Contribution to journal › Article (E-pub ahead of print)
Organiser
Programme Organising Committee Member as follows
Society for Endocrinology Career Development Workshop Co-organiser 2007-2014
Metabolomics Society, Glasgow 2013
Scoiety for Endocrinology, UK Meetings, 2013-2018
Scottish Metabolomics Network, Edinburgh 2015
Androgens, Edinbrugh 2018
European Oxysterol Research Network, Edinburgh 2019