Ruth Andrew (BSc, PhD, MRPharmS)
Personal Chair of Pharmaceutical Endocrinology
Address
- Street
-
The Queen's Medical Research Institute,
Edinburgh BioQuarter,
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Background
Ruth Andrew graduated as a pharmacist from the University of Strathclyde, Glasgow, UK in 1989 and carried out her PhD in pharmaceutical analysis using GC-MS to study synthesis and metabolism of adrenal medullary hormones in hypertensive subjects. She gained a lectureship in the University of Edinburgh in 1994 and was awarded a Chair in Pharmaceutical Endocrinology in 2015. She specialises in understanding regulation of glucocorticoid action in metabolic and inflammatory diseases and has developed innovative tools to study steroid metabolism and flux in vivo, most recently by mass spectrometry imaging. She also is the Director of the Mass Spectrometry Core of the Edinburgh Clinical Research Facility; this laboratory supports a broad spectrum support for clinical researchers requiring small molecule analysis in their research programmes, including studies of toxicology, drug discovery, experimental physiology and pathology. She plays an active role in undergraduate and post-graduate teaching in Endocrine Pharmacology.
Qualifications
BSc Hons First Class Pharmacy (specialisation Pharmaceutical Chemistry)
PhD Pharmaceutical Chemistry
MRPharmS
Post-graduate Certificate in Higher Education
Responsibilities & affiliations
Director, Edinburgh Clinical Research Facility, Mass Spectrometry Core
Society for Endocrinology General Secretary, Council Member and Finance Committee Member
Scottish Metabolomics Network, Scientific Board (Treasurer until 2021)
European Oxysterol Research Network Scientific Board
British Journal of Pharmacology Reviews Editor
Frontiers in Endocrinology, Specialty Chief Editor, Systems Endocrinology
Talanta, Associate Editor
Chair Seminar Committee, Centre for Cardiovascular Science
Post-graduate Appeals Committee Member
Grant Panellist for Wellcome Trust, FWO, NCN, BBSRC, CSO
Undergraduate teaching
Endocrine Physiology and Pharmacology, Honours Biomedical Sciences, Deputy Course Organiser
Contributing Lecturer, Y3 BSc Clinical Biochemistry and Endocrinology
Postgraduate teaching
Centre for Cardiovascular Science Post-graduate Committee Member
University Post-graduate Appeals Committee Member
Contributing Lecturer, MSc Cardiovascular Biology
External Lecturer, MSc Pharmaceutical Analysis, University of Strathclyde
Open to PhD supervision enquiries?
Yes
Research summary
My research interests are in steroid biochemistry and applied mass spectrometry. I study glucocorticoids and their actions on fuel metabolism and inflammation. I have a particular interest in the enzyme 5alpha-reductase, which activates androgens and modulates glucocorticoid action. Inhibitors of the enzyme used in prostate disease alter steroid hormone action and my group has shown that inhibition of this enzyme increases susceptibility to insulin resistance and type 2 diabetes. I am also interested in studying 5alpha-reduced glucocorticoids as potential dissociated glucocorticoid receptor modulators. Lastly I apply mass spectrometry to enable tracking of steroid metabolism, using stable-isotope tracers and also advanced methods of MS detection e.g. imaging.
Current research interests
Pharmacoepidemiology of adverse effects of 5alpha-reductase inhibitors on devlopment of type 2 diabetes. The role of 5alpha-reductases in modulating fuel homeostaisis. Application of advanced mass spectrometry to visualise and track steroid hormones in biological systems. Spatial Lipidomics in cardiovascualr dideaseKnowledge exchange
Consultant for Actinogen Medical
Current project grants
2024 Chinese Scholarship Commission Visiting Scholar Fellowship (Host for J Wang)
2023-2029 MRC Partnership Grant (O’Donnell, Griffiths, Andrew, Campopiano, Andrews, Stephens, Hawkins, Andrews, Dennis (£1.29M)
Systems Lipidomics tools and resources for biomedical research; LIPID MAPS
2023-2026 Heart Research UK (Andrew, Newby, Hadoke, Sellers, Ntshangase) (£250k)
Spatial Profiling of Lipoprotein (a) and Plaque Vulnerability
2023-2028 BHF Programme Grant (Newby DE, Baker AJ, Dweck MR, Mills NL, Williams MC, Tavares AAS, Henderson N, Andrew R, Sellers S, Brittan M) £1,943,103.52
Finding a Cure for Aortic Stenosis
2022-23 Michael Smith Foreign Study Supplement (6,000 Canadian dollars)
Host sponsor for visiting PhD scholar Miss Melody Salehzadeh
2022-2023 BHF REA3 Small Project (£25k) (Ntshangase S, Newby DE, Hadoke PWF, Andrew R)
Developing an MS-based spatial proteomics approach: application to cardiovascular research
2022-2023 Friedman Award for Scholars in Health (Salehzadeh M, Soma K, Andrew R) CAD $49261
Mass spectrometry imaging of glucocorticoids in the mouse thymus
2022-2026 MRC-DTP Precision Medicine Studentship Tu H, Andrew R, Wei L, Michoel T Pearson EZ
“5α-Reductases: Mapping pathways of Metabolic Disease” (~£160K)
2022-2023 Mitacs Globalink Research Award - UK Research and Innovation (UKRI) (Salehzadeh M, Soma K, Andrew R)
Mass spectrometry imaging of glucocorticoids in the mouse thymus (CAD $6000)
2021-2025 Wellcome Trust One Health PhD Studentship (Gray GA, Khan S, Andrew R)
Repurposing 11HSD1 Inhibitors in a pig model of myocardial infarction
2021-2025 Eastbio PhD Studentship (Selvakumar M with Andrew R, Fallowfield J, Webster SP) (~£100k)
Defining lipidomic biomarkers of the interactions between Western diet and liver health using mass spectrometry imaging
2020-2023 BBSRC Biomedical Resource Fund (£800k)
3D Neurosterol Atlas of the Mouse Brain (Griffiths WJ (PI), Wang Y; Andrew R (PI), Yau JWL)
2020-2024 MRC Project Grant (MacLean MR, Andrew R) (£689k)
Oestrogen and oestrogen metabolites in pulmonary arterial hypertension
2019-2023 MRC-DTP Studentship (J Weatherill with Andrew R, MacLean MR, Webster SP) (~£95k)
Investigating estrogen metabolism in Pulmonary Arterial Hypertension by MS Imaging
2017-2023 Wellcome Trust Multi-User Equipment Grant (£793,450)
Mass Spectrometry Imaging in Translational Endocrine Research
(Andrew R, Walker BR, Webster SW, Newby DE, Saunders PTK, Reynolds RM)
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Re-analysis of lipidomic data reveals Specialised Pro-Resolution Lipid Mediators (SPMs) to be lower than quantifiable limits of assay in a human model of resolving inflammation
DOI: https://doi.org/10.1101/2023.03.06.530669
Research output: › Preprint (Published) -
11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis
In:
PLoS ONE, vol. 18, pp. e0255709
DOI: https://doi.org/10.1371/journal.pone.0255709
Research output: Contribution to Journal › Article (Published) -
The ATP-binding cassette proteins ABCB1 and ABCC1 as modulators of glucocorticoid action
In:
Nature reviews endocrinology
DOI: https://doi.org/10.1038/s41574-022-00745-9
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19 F-magnetic resonance spectroscopy
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-022-18740-5
Research output: Contribution to Journal › Article (Published) -
Marked oestrous cycle-dependent regulation of rat arterial KV7.4 channels driven by GPER1
In:
British Journal of Pharmacology
DOI: https://doi.org/10.1111/bph.15947
Research output: Contribution to Journal › Article (Published) -
Mapping Endocrine Networks by Stable Isotope Tracing
In:
Current Opinion in Endocrine and Metabolic Research
DOI: https://doi.org/10.1016/j.coemr.2022.100381
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Comparison of mechanisms of angiostasis caused by the anti-inflammatory steroid 5α-tetrahydrocorticosterone versus conventional glucocorticoids
In:
European Journal of Pharmacology, pp. 175111
DOI: https://doi.org/10.1016/j.ejphar.2022.175111
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Increased adipose tissue indices of androgen catabolism and aromatization in women with metabolic dysfunction
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM)
DOI: https://doi.org/10.1210/clinem/dgac261
Research output: Contribution to Journal › Article (Published) -
ABCC1 modulates negative feedback control of the hypothalamic-pituitary-adrenal axis in vivo in humans
In:
Metabolism, vol. 128
DOI: https://doi.org/10.1016/j.metabol.2021.155118
Research output: Contribution to Journal › Article (Published) -
Derivatization with 2-Hydrazino-1-methylpyridine Enhances Sensitivity of Analysis of 5α-Dihydrotestosterone in Human Plasma by Liquid Chromatography Tandem Mass Spectrometry
In:
Journal of Chromatography A
DOI: https://doi.org/10.1016/j.chroma.2021.461933
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Effects of Obesity And Insulin on Tissue-Specific Recycling Between Cortisol And Cortisone in Men
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM)
DOI: https://doi.org/10.1210/clinem/dgaa896
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mass spectrometry: future opportunities for profiling and imaging steroids and steroid metabolites
In:
Current Opinion in Endocrine and Metabolic Research
DOI: https://doi.org/10.1016/j.coemr.2020.11.005
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Insights from the Menstrual Cycle in Pulmonary Arterial Hypertension
In:
Annals of the American Thoracic Society
DOI: https://doi.org/10.1513/AnnalsATS.202006-671OC
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Sexual dimorphism in cortisol metabolism throughout pubertal development: a longitudinal study
In:
Endocrine connections
DOI: https://doi.org/10.1530/EC-20-0123
Research output: Contribution to Journal › Article (Published) -
Exploring the Temporal Relation between Body Mass Index and Corticosteroid Metabolite Excretion in Childhood
In:
Nutrients, vol. 12, pp. 1525
DOI: https://doi.org/10.3390/nu12051525
Research output: Contribution to Journal › Article (Published) -
Estrogen Signaling and Portopulmonary Hypertension: The Pulmonary Vascular Complications of Liver Disease Study (PVCLD2)
In:
Hepatology
DOI: https://doi.org/10.1002/hep.31314
Research output: Contribution to Journal › Article (Published) -
Diet-induced weight loss alters hepatic glucocorticoid metabolism in type 2 diabetes mellitus
In:
European Journal of Endocrinology, vol. 182, pp. 447-457
DOI: https://doi.org/10.1530/EJE-19-0901
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Long-term stability of cortisol production and metabolism throughout adolescence: longitudinal twin study
In:
Twin Research and Human Genetics
DOI: https://doi.org/10.1017/thg.2020.6
Research output: Contribution to Journal › Article (Published) -
Highlights into the pharmacology of nutraceuticals
In:
British Journal of Pharmacology, vol. 177, pp. 1209-1211
DOI: https://doi.org/10.1111/bph.15006
Research output: Contribution to Journal › Editorial (Published) -
Maternal glucocorticoid metabolism across pregnancy: a potential mechanism underlying fetal glucocorticoid exposure
In:
The Journal of Clinical Endocrinology & Metabolism (JCEM), vol. 105
DOI: https://doi.org/10.1210/clinem/dgz313
Research output: Contribution to Journal › Article (Published)
Invited speaker
2023 Lipidmaps Webinar
2022 BMSS Lipidomics Special Interest Group Webinar
2022 Celebrating Cedric Shackleton Symposium
2021 Society for Endocrinology Research Skills: Grant writing and rebuttal
2021 MSACL Fireside Chat
2020 MSACL Interview Workshop
2020 Oxford University, Diabetes and Endocrinology Metabolism Seminars
2019 Laval University, Seminar Series, Quebec
“Tracing steroids to understand the Metabolic Syndrome”
2018 Peter Derrick Memorial Symposium, American Chemical Society Fall Meeting, Boston
“Imaging steroids by Mass Spectrometry – challenges and opportunities”
Organiser
Programme Organising Committee Member as follows
Society for Endocrinology Career Development Workshop Co-organiser 2007-2014
Metabolomics Society, Glasgow 2013
Scoiety for Endocrinology, UK Meetings, 2013-2018
Scottish Metabolomics Network, Edinburgh 2015
Androgens, Edinbrugh 2018
European Oxysterol Research Network, Edinburgh 2019
Adipose Tissue Discussion Group 2021, 2022