Professor Suvankar Pal (BSc(Hons) MBBS(Distinction) MRCP(Neurology) MD(Res) PGCME FHEA FRCP)
Professor of Neurodegenerative Disorders and Clinical Trials & Honorary Consultant Neurologist

- Centre for Clinical Brain Sciences
- Anne Rowling Regenerative Neurology Clinic
- Euan MacDonald Centre for Motor Neuron Disease Research
Contact details
- Email: suvankar.pal@ed.ac.uk
Address
- Street
-
Room FU303J
Centre for Clinical Brain Sciences
Chancellor's Building, The University of Edinburgh - City
- Edinburgh
- Post code
Background
Suvankar Pal is Professor of Neurodegenerative Disorders and Clinical Trials and Honorary Consultant Neurologist. He is co-lead investigator of the UK wide innovative multi-arm multi-stage MND SMART trial, the Scottish Motor Neuron Disease Register (CARE-MND), a Deputy Director at the Anne Rowling Clinic, Clinical Lead of the UK National CJD Research and Surveillance Unit, and Clinical Lead for Neurology at NHS Forth Valley. His clinical and research interests are focused on improving outcomes for people with neurodegenerative disorders, including accelerating early and accurate diagnoses, evaluating atypical presentations, leading population-based disease registries for longitudinal deep clinical phenotyping, digital and wet lab biomarker development/reverse translation, and delivery of innovative clinical trials.
Qualifications
Suvankar graduated in Neurosciences and Medicine with Distinction in Clinical Sciences from King’s College London in 2001, completed basic medical training at the Royal Postgraduate Medical School (Hammersmith Hospital and National Hospital for Neurology), and Royal Free Hospital, before completing his Doctoral research investigating novel molecular diagnostic strategies in Prion disease and supporting recruitment to the PRION1 trial at the MRC Prion Unit Institute of Neurology UCL. He completed higher specialist training in neurology in Edinburgh and was appointed to a Consultant Neurologist position in 2011 at NHS Forth Valley and the University of Edinburgh. Suvankar completed a Postgraduate Certificate in Medical Education from UCL/Royal College of Physicians in 2012 and is a Fellow of the Higher Education Academy. He was awarded an inaugural NHS Scotland Research Fellowship in 2012, and appointed to a Clinical Senior Lecturer Position at the Centre for Clinical Brain Sciences in 2018. He was awarded a Personal Chair in Neurodegenerative Disorders and Clinical Trials at the University of Edinburgh in 2023 and holds an Honorary Professorship at the MRC Clinical Trials Unit at UCL where he co-chairs the ACORD Fellows Academy.
Responsibilities & affiliations
Co-lead Investigator Motor Neurone Disease - Systematic Multi-Arm Adaptive Randomised Trial (https://www.mnd-smart.org)
Co-Lead Investigator Scottish Motor Neurone Disease Register (CARE-MND) (https://www.care-mnd.org.uk)
Clinical Lead National CJD Research & Surveillance Unit (https://www.cjd.ed.ac.uk)
Deputy Director (Neurodegeneration) Anne Rowling Regenerative Neurology Clinic (https://www.annerowlingclinic.org)
Clinical Lead for Neurology NHS Forth Valley (https://nhsforthvalley.com/health-services/az-of-services/neurology/)
Co-Chair ACORD Fellows Academy (MRC Clinical Trials Unit at UCL (https://www.mrcctu.ucl.ac.uk/our-research/neurodegenerative-diseases/acord-collaboration/mrc-clinical-trials-unit-acord-fellows-academy/)
Undergraduate teaching
Lead for Year 2 MBChB Command & Control Module
Postgraduate teaching
Co-Chair ACORD Fellows Academy (https://www.mrcctu.ucl.ac.uk/our-research/neurodegenerative-diseases/acord-collaboration/mrc-clinical-trials-unit-acord-fellows-academy/)
Open to PhD supervision enquiries?
Yes
Current PhD students supervised
Dr Johnny Tam
Dr John Centola
Dr Jane Lumsden
Past PhD students supervised
Dr Neil Watson
Dr Emily Beswick
Dr Briony Waddell
Dr Monica Icaza Valenzuela
Dr Harriet Ingle
Research summary
- Delivery of innovative clinical trials for neurodegenerative disorders including co-lead investigator for MND SMART (www.mnd-smart.org)
- Comprehensive longitudinal clinical registries for neurodegenerative disorders (including MND, dementia, and CJD)
- Reverse translation/Development and validation of sensitive and specific digital and blood based biomarkers
Project activity
MND SMART Clinical Trial (https://www.mnd-smart.org)
CARE-MND (https://www.care-mnd.org.uk)
National CJD Research & Surveillance Unit (https://www.cjd.ed.ac.uk)
-
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
In:
Science Advances
DOI: https://doi.org/10.1126/sciadv.abq0651
Research output: Contribution to Journal › Article (Published) -
Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus
In:
BMJ Open, vol. 13, pp. e064169
DOI: https://doi.org/10.1136/bmjopen-2022-064169
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Statistical Analysis Plan for the Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART)
In:
Trials, vol. 24, pp. 29
DOI: https://doi.org/10.1186/s13063-022-07007-z
Research output: Contribution to Journal › Article (Published) -
Genotype-phenotype characterisation of long survivors with motor neuron disease in Scotland
In:
Journal of Neurology
DOI: https://doi.org/10.1007/s00415-022-11505-0
Research output: Contribution to Journal › Article (Published) -
Sporadic Creutzfeldt-Jakob Disease in the young (50 and below): 10-year review of United Kingdom surveillance
In:
Journal of Neurology
DOI: https://doi.org/10.1007/s00415-022-11467-3
Research output: Contribution to Journal › Article (Published) -
Prion disease: clinical pathway development for the terminally ill
In:
BMJ Supportive & Palliative Care
DOI: https://doi.org/10.1136/spcare-2022-003877
Research output: Contribution to Journal › Letter (Published) -
A systematic review of digital technology to evaluate motor function and disease progression in motor neuron disease
In:
Journal of Neurology
DOI: https://doi.org/10.1007/s00415-022-11312-7
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease
In:
BMJ Open, vol. 12, pp. e064173
DOI: https://doi.org/10.1136/bmjopen-2022-064173
Research output: Contribution to Journal › Article (Published) -
Smarter adaptive platform clinical trials in neurology: a showcase for UK innovation
In:
Brain
DOI: https://doi.org/10.1093/brain/awac169
Research output: Contribution to Journal › Letter (Published) -
Concordance of cerebrospinal fluid real‐time quaking‐induced conversion across the European Creutzfeldt–Jakob Disease Surveillance Network
In:
European Journal of Neurology
DOI: https://doi.org/10.1111/ene.15387
Research output: Contribution to Journal › Article (Published) -
Allocentric visuomotor processing is particularly sensitive to cognitive decline: evidence from the iReach iPad app in prodromal and clinical Alzheimer’s disease
Research output: Contribution to Conference › Poster (Unpublished) -
Peripheral reaching in Alzheimer’s disease and mild cognitive impairment
In:
Cortex, vol. 149
DOI: https://doi.org/10.1016/j.cortex.2022.01.003
Research output: Contribution to Journal › Article (Published) -
Motor Neuron Disease is not clustered or associated with socioeconomic deprivation in Scotland
DOI: https://doi.org/10.1101/2022.02.27.22271535
Research output: › Preprint (Published) -
Validation of Revised International Creutzfeldt-Jakob Disease Surveillance Network Diagnostic Criteria for Sporadic Creutzfeldt-Jakob Disease
In:
JAMA Network Open, vol. 5, pp. e2146319
DOI: https://doi.org/10.1001/jamanetworkopen.2021.46319
Research output: Contribution to Journal › Article (Published) -
Impact of the COVID‐19 pandemic on Creutzfeldt–Jakob disease surveillance and patient care in the United Kingdom
In:
European Journal of Neurology
DOI: https://doi.org/10.1111/ene.15228
Research output: Contribution to Journal › Article (Published) -
Trials for neurodegenerative diseases: time to innovate
In:
Lancet Neurology, vol. 20, pp. 984
DOI: https://doi.org/10.1016/S1474-4422(21)00388-4
Research output: Contribution to Journal › Comment/debate (Published) -
Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective
In:
Brain Communications, vol. 3
DOI: https://doi.org/10.1093/braincomms/fcab242
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The prevalence of multimorbidity and its impact on survival in people with motor neuron disease
(10 pages)
In:
European Journal of Neurology, vol. 28, pp. 2756-2765
DOI: https://doi.org/10.1111/ene.14940
Research output: Contribution to Journal › Article (Published) -
Phenotypic diversity of genetic Creutzfeldt–Jakob disease: a histo-molecular-based classification
In:
Acta Neuropathologica
DOI: https://doi.org/10.1007/s00401-021-02350-y
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A systematic review of non-motor symptom evaluation in clinical trials for amyotrophic lateral sclerosis
In:
Journal of Neurology
DOI: https://doi.org/10.1007/s00415-021-10651-1
Research output: Contribution to Journal › Article (Published)