Prof David Argyle
William Dick Chair of Veterinary Clinical Studies
Contact details
Address
- Street
-
The Royal (Dick) School of Veterinary Studies
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Availability
Willingness to take Ph.D. students: Yes
Background
David Argyle graduated from the University of Glasgow veterinary School and subsequently worked in general practice. He returned to Glasgow to complete a PhD in the department of Veterinary Pathology and then worked as a lecturer and senior lecturer in clinical oncology in the Department of Clinical Studies. In 2002, he became Associate Professor of clinical oncology at the University of Wisconsin-Madison, USA. In 2005 he returned to the UK to take the William Dick Chair of clinical studies at the University of Edinburgh. On his return he set up the R(D)SVS Cancer and Imaging Centre. He in an RCVS and European Specialist in Veterinary Oncology, a Diplomat of the European College of Internal Medicine in Oncology and is co-scientific editor of the Journal of Veterinary and Comparative Oncology. Within the R(D)SVS he is the Dean of Veterinary Medicine and Head of School and is also the Deputy Head of The College of Medicine and Veterinary Medicne. he has overall responsibility for the School including it's research arm, the Roslin Institute. In 2016 he was elected Fellow of the Royal Society of Edinburgh. In the same year he was elected Fellow of the Royal College of Veterinary Surgeons (for meritorious contributions to veterinary research).
Collaborative Activity
Professor Ted Hupp
Professor Steve McLaughlin (Heriot-Watt University)
Professor Mark Bradley
Professor Andy Mount
Professor Ian Kunkler
Dr. Simon Langdon
Professor Joyce Tait (Innogen)
Dr. Jan Mol (Utrecht)
Qualifications
Doctor of Philosophy (PhD), University of Glasgow Cloning, Sequencing, Expression and Characterization of Feline Interferon-Gamm Bachelor of Veterinary Medicine & Surgery, University of Glasgow
Professional Qualifications
Diplomate of the European College of Veterinary Internal Medicine, DECVIM-CA (Oncology) Member of the Royal College of Veterinary Surgeons (Register Index Number: 6191897), MRCVS
Responsibilities & affiliations
Head of School
Research summary
Mechanistic studies into canine disease, specifically the focus of my research is comparative cancer biology. This involves studies on the stem cell basis of cancer through to the translation of new therapeutics into clinical development.
Current research interests
The Comparative Oncology and Stem Cell Research Group is a multidisciplinary team that draws its expertise from both clinical and laboratory trained staff and is further augmented by collaborations within the Edinburgh area research community (University of Edinburgh cancer research centre, The Roslin Institute) the USA and EU. Our approach to the integration of laboratory and clinical research make us well placed to carry out high quality translational studies. Many of the group members are also faculty members of the Royal (Dick) School of Veterinary Studies.-
Switching on prodrugs using radiotherapy
In:
Nature Chemistry
DOI: https://doi.org/10.1038/s41557-021-00711-4
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Corrigendum: Comparative Analysis of the Development of Acquired Radioresistance in Canine and Human Mammary Cancer Cell Lines
In:
Frontiers in Veterinary Science, vol. 8, pp. 664680
DOI: https://doi.org/10.3389/fvets.2021.664680
Research output: Contribution to Journal › Article (Published) -
Hydrogen Deuterium Exchange Mass Spectrometry identifies the dominant paratope in CD20 antigen binding to the NCD1.2 monoclonal antibody
In:
Biochemical Journal, vol. 478, pp. 99-120
DOI: https://doi.org/10.1042/BCJ20200674
Research output: Contribution to Journal › Article (Published) -
Liquid biopsy based on small extracellular vesicles predicts chemotherapy response of canine multicentric lymphomas
In:
Scientific Reports, vol. 10, pp. 20371
DOI: https://doi.org/10.1038/s41598-020-77366-7
Research output: Contribution to Journal › Article (Published) -
The importance of the tumour microenvironment and hypoxia in delivering a precision medicine approach to veterinary oncology
In:
Frontiers in Veterinary Science
DOI: https://doi.org/10.3389/fvets.2020.598338
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Exosomes as Biomarkers of Human and Feline Mammary Tumours; A Comparative Medicine Approach to Unravelling the Aggressiveness of TNBC
In:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, vol. 1874, pp. 188431
DOI: https://doi.org/10.1016/j.bbcan.2020.188431
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
A blocking antibody against canine CSF-1R maturated by limited CDR mutagenesis
(12 pages)
In:
Antibody therapeutics, vol. 3, pp. 193-204
DOI: https://doi.org/10.1093/abt/tbaa018
Research output: Contribution to Journal › Article (Published) -
Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor
(12 pages)
In:
Sensing and Bio-Sensing Research, vol. 30, pp. 1-12
DOI: https://doi.org/10.1016/j.sbsr.2020.100375
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Comparative Analysis of the Development of Acquired Radioresistance in Canine and Human Mammary Cancer Cell Lines
In:
Frontiers in Veterinary Science
DOI: https://doi.org/10.3389/fvets.2020.00439
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Transcriptomic analysis by RNA sequencing characterises malignant progression of canine insulinoma from normal tissue to metastatic disease
In:
Scientific Reports, vol. 10
DOI: https://doi.org/10.1038/s41598-020-68507-z
Research output: Contribution to Journal › Article (E-pub ahead of print)