Prof David Argyle
William Dick Chair of Veterinary Clinical Studies
Contact details
Address
- Street
-
The Royal (Dick) School of Veterinary Studies
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Availability
Willingness to take Ph.D. students: Yes
Background
David Argyle graduated from the University of Glasgow veterinary School and subsequently worked in general practice. He returned to Glasgow to complete a PhD in the department of Veterinary Pathology and then worked as a lecturer and senior lecturer in clinical oncology in the Department of Clinical Studies. In 2002, he became Associate Professor of clinical oncology at the University of Wisconsin-Madison, USA. In 2005 he returned to the UK to take the William Dick Chair of clinical studies at the University of Edinburgh. On his return he set up the R(D)SVS Cancer and Imaging Centre. He in an RCVS and European Specialist in Veterinary Oncology, a Diplomat of the European College of Internal Medicine in Oncology and is co-scientific editor of the Journal of Veterinary and Comparative Oncology. Within the R(D)SVS he is the Dean of Veterinary Medicine and Head of School and is also the Deputy Head of The College of Medicine and Veterinary Medicne. he has overall responsibility for the School including it's research arm, the Roslin Institute. In 2016 he was elected Fellow of the Royal Society of Edinburgh. In the same year he was elected Fellow of the Royal College of Veterinary Surgeons (for meritorious contributions to veterinary research).
Collaborative Activity
Professor Ted Hupp
Professor Steve McLaughlin (Heriot-Watt University)
Professor Mark Bradley
Professor Andy Mount
Professor Ian Kunkler
Dr. Simon Langdon
Professor Joyce Tait (Innogen)
Dr. Jan Mol (Utrecht)
Qualifications
Doctor of Philosophy (PhD), University of Glasgow Cloning, Sequencing, Expression and Characterization of Feline Interferon-Gamm Bachelor of Veterinary Medicine & Surgery, University of Glasgow
Professional Qualifications
Diplomate of the European College of Veterinary Internal Medicine, DECVIM-CA (Oncology) Member of the Royal College of Veterinary Surgeons (Register Index Number: 6191897), MRCVS
Responsibilities & affiliations
Head of School
Research summary
Mechanistic studies into canine disease, specifically the focus of my research is comparative cancer biology. This involves studies on the stem cell basis of cancer through to the translation of new therapeutics into clinical development.
Current research interests
The Comparative Oncology and Stem Cell Research Group is a multidisciplinary team that draws its expertise from both clinical and laboratory trained staff and is further augmented by collaborations within the Edinburgh area research community (University of Edinburgh cancer research centre, The Roslin Institute) the USA and EU. Our approach to the integration of laboratory and clinical research make us well placed to carry out high quality translational studies. Many of the group members are also faculty members of the Royal (Dick) School of Veterinary Studies.-
Epithelial-mesenchymal transition as a fundamental mechanism underlying the cancer phenotype
In:
Veterinary and Comparative Oncology, vol. 11, pp. 169-184
DOI: https://doi.org/10.1111/j.1476-5829.2011.00313.x
Research output: Contribution to Journal › Literature review (Published) -
Veterinary and Comparative Oncology, A decade in cancer research
In:
Veterinary and Comparative Oncology, vol. 10, pp. 1
DOI: https://doi.org/10.1111/j.1476-5829.2012.00323.x
Research output: Contribution to Journal › Comment/debate (Published) -
Stem cells and veterinary medicine: Tools to understand diseases and enable tissue regeneration and drug discovery
(9 pages)
In:
The Veterinary Journal, vol. 191, pp. 19-27
DOI: https://doi.org/10.1016/j.tvjl.2011.08.007
Research output: Contribution to Journal › Article (Published) -
Characterisation and cardiac directed differentiation of canine adult cardiac stem cells
(7 pages)
In:
The Veterinary Journal, vol. 191, pp. 176-182
DOI: https://doi.org/10.1016/j.tvjl.2010.12.033
Research output: Contribution to Journal › Article (Published) -
Identification of tumour initiating cells in feline head and neck squamous cell carcinoma and evidence for gefitinib induced epithelial to mesenchymal transition.
(7 pages)
In:
The Veterinary Journal, vol. 193, pp. 46-52
DOI: https://doi.org/10.1016/j.tvjl.2012.01.009
Research output: Contribution to Journal › Article (Published) -
Feline lung-digit syndrome: Unusual metastatic patterns of primary lung tumours in cats
(7 pages)
In:
Journal of Feline Medicine and Surgery, vol. 14, pp. 202-8
DOI: https://doi.org/10.1177/1098612X12439267
Research output: Contribution to Journal › Article (Published) -
Studies on the inhibition of feline EGFR in squamous cell carcinoma: Enhancement of radiosensitivity and rescue of resistance to small molecule inhibitors
(11 pages)
In:
Cancer Biology and Therapy, vol. 11, pp. 927-937
DOI: https://doi.org/10.4161/cbt.11.11.15525
Research output: Contribution to Journal › Article (Published) -
Expression of epidermal growth factor receptor (EGFR) and Ki67 in feline oral squamous cell carcinomas (FOSCC)
(12 pages)
In:
Veterinary and Comparative Oncology, vol. 9, pp. 106-117
DOI: https://doi.org/10.1111/j.1476-5829.2010.00239.x
Research output: Contribution to Journal › Article (Published) -
CD44 is associated with proliferation, rather than a specific cancer stem cell population, in cultured canine cancer cells
(12 pages)
In:
Veterinary Immunology and Immunopathology, vol. 141, pp. 46-57
DOI: https://doi.org/10.1016/j.vetimm.2011.02.004
Research output: Contribution to Journal › Article (Published) -
Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
(15 pages)
In:
Leukemia & Lymphoma, vol. 52, pp. 1321-1335
DOI: https://doi.org/10.3109/10428194.2011.559802
Research output: Contribution to Journal › Article (Published)