Pierre Bagnaninchi
- Centre for Regenerative Medicine
- Institute for Regeneration and Repair
Contact details
- Tel: 0131 651 9500
- Email: pierre.bagnaninchi (AT) ed.ac.uk
Address
- Street
-
Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Background
Dr Pierre-Olivier Bagnaninchi is a principal investigator at the College of Medicine and Veterinary Medicine (CMVM), at the University of Edinburgh (UoE).
Pierre-Olivier studied theoretical physics (MSc, 97) before moving to the field of biomedical engineering. He obtained his PhD in biomedical engineering in 2001 from the University of Grenoble, France in partnership with Thales optoelectronics. He then joined Prof. Maryam Tabrizian's lab at McGill University to develop impedance-based biosensors for tissue engineering applications. In 2004, he joined the Institute of Science and Technology for Medicine at Keele University (UK) under the supervision of Prof. Alicia El Haj and Professor Ruikang Wang to develop a polarization-sensitive optical coherence tomography system. In 2008 he was awarded a 5-year RCUK fellowship at the University of Edinburgh to develop as an independent researcher novel label-free technologies for tissue engineering and regenerative medicine.
Pierre Bagnaninchi is a member of EPSRC, BBSRC and MRC funded Organ on a chip technologies network (www.organonachip.org.uk), for which he leads a Special interest group: Label-free real-time monitoring, translation to organ on a chip.
Pierre Bagnaninchi is a guest professor at Nanjing University of Aeronautics and Astronautics since November 2022.
Publications on Google scholar: https://scholar.google.co.uk/citations?hl=en&user=JpB-ZcgAAAAJ&view_op=list_works&sortby=pubdate
ORCID profile: https://orcid.org/0000-0001-5433-9630
Open to PhD supervision enquiries?
Yes
Research summary
Our main research interest is the development of label-free quantitative technologies to map biophysical properties (mechanical, optical, flow, electrical) of cells and tissues. They also address the need for real-time monitoring of 3D (spheroids, organoids) in vitro disease models, and the need to monitor tissue repair in pre-clinical studies. To this end, we currently investigate optical coherence tomography, impedance sensing and their combination into organ-on-a chip technologies with a focus on ophthalmological applications.
We currently have projects on:
- Optical coherence tomography for tissue engineering and regenerative medicine
- Measuring the mechanical properties of cells and tissues by optical means
- Noninvasive biosensors and quantitative methods in medicine and biology:
- Label-free Impedance-based cellular assays (ECIS, EIT)
- Label-free 3D optical toxicity assays
- Organ-on-a-chip models of age-related macular degeneration
Pierre Bagnaninchi is a member of EPSRC, BBSRC and MRC funded Organ on a chip technologies network (www.organonachip.org.uk), for which he leads a Special interest group: Label-free real-time monitoring, translation to organ on a chip.
Publications on Google scholar: https://scholar.google.co.uk/citations?hl=en&user=JpB-ZcgAAAAJ&view_op=list_works&sortby=pubdate
ORCID profile: https://orcid.org/0000-0001-5433-9630
-
Debiased ambient vibrations optical coherence elastography to profile cell, organoid and tissue mechanical properties
In:
Communications biology
DOI: https://doi.org/10.1038/s42003-023-04788-0
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Dual-modal Image Reconstruction for Electrical Impedance Tomography with Overlapping Group Lasso and Laplacian Regularization
In:
IEEE Transactions on Biomedical Engineering, pp. 1-12
DOI: https://doi.org/10.1109/TBME.2023.3243781
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Enhanced Multi-Scale Feature Cross-Fusion Network for Impedance-optical Dual-modal Imaging
(1 page)
In:
IEEE Sensors Journal, pp. 1
DOI: https://doi.org/10.1109/JSEN.2022.3200758
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Quantitative Action Spectroscopy Reveals ARPE-19 Sensitivity to Long-Wave 1 Ultraviolet Radiation at 350 nm and 380 nm
In:
Scientific Reports, vol. 12
DOI: https://doi.org/10.1038/s41598-022-17251-7
Research output: Contribution to Journal › Article (Published) -
The Hippo pathway drives the cellular response to hydrostatic pressure
In:
EMBO Journal, vol. 41, pp. e108719
DOI: https://doi.org/10.15252/embj.2021108719
Research output: Contribution to Journal › Article (Published) -
Optical Cellular Micromotion: A New Paradigm to Measure Tumor Cells Invasion within Gels Mimicking the 3D Tumor Environments
(13 pages)
In:
Small Methods, vol. 6
DOI: https://doi.org/10.1002/smtd.202200471
Research output: Contribution to Journal › Article (Published) -
Evaluation of a dual-modal tissue imaging framework based on information fusion using optical coherence and bioimpedance tomography
DOI: https://doi.org/10.1117/12.2621609
Research output: Contribution to Conference › Conference contribution (Published) -
MMV-Net: A Multiple Measurement Vector Network for Multi-frequency Electrical Impedance Tomography
(12 pages)
In:
IEEE Transactions on Neural Networks and Learning Systems, pp. 1-12
DOI: https://doi.org/10.1109/TNNLS.2022.3154108
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Impedance-optical Dual-modal Cell Culture Imaging with Learning-based Information Fusion
In:
IEEE Transactions on Medical Imaging, pp. 1-1
DOI: https://doi.org/10.1109/TMI.2021.3129739
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Measuring 3D Cell Culture Viability in Multiple 3D Printed Scaffolds Within a Single Miniature Electrical Impedance Tomography Sensor
(9 pages)
In:
Advanced Engineering Materials, vol. 23
DOI: https://doi.org/10.1002/adem.202100338
Research output: Contribution to Journal › Article (Published) -
Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]
In:
Journal of Hepatology
DOI: https://doi.org/10.1016/j.jhep.2021.06.021
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Time-resolved spectral-domain optical coherence tomography with CMOS SPAD sensors
(14 pages)
In:
Optics Express, vol. 29, pp. 18720-18733
DOI: https://doi.org/10.1364/OE.422648
Research output: Contribution to Journal › Review article (Published) -
Application of Impedance-Based Techniques in Hepatology Research
(18 pages)
In:
Journal of Clinical Medicine, vol. 9
DOI: https://doi.org/10.3390/jcm9010050
Research output: Contribution to Journal › Article (Published) -
Impedance-optical Dual-modal Sensor and Image Reconstruction for Cell Spheroids Imaging
DOI: https://doi.org/10.1109/SENSORS47125.2020.9278662
Research output: Contribution to Conference › Conference contribution (Published) -
Impedance-Optical Dual-Modal Sensor and Image Reconstruction Framework for Cell Imaging
DOI: https://doi.org/10.1109/SENSORS47125.2020.9278662
Research output: Contribution to Conference › Conference contribution (E-pub ahead of print) -
Hybrid Learning based Cell Aggregate Imaging with Miniature Electrical Impedance Tomography
In:
IEEE Transactions on Instrumentation and Measurement, vol. 70
DOI: https://doi.org/10.1109/TIM.2020.3035384
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Deep Learning Based Cell Imaging with Electrical Impedance Tomography
DOI: https://doi.org/10.1109/I2MTC43012.2020.9128764
Research output: Contribution to Conference › Conference contribution (E-pub ahead of print) -
Blur resolved OCT: full-range interferometric synthetic aperture microscopy through dispersion encoding
In:
Optics Express, vol. 28
DOI: https://doi.org/10.1364/OE.379216
Research output: Contribution to Journal › Article (Published) -
Role of impedance based cellular assays in Hepatology research
Research output: › Chapter (peer-reviewed) (Published) -
Application of Impedance-Based Techniques in Hepatology Research
In:
Journal of Clinical Medicine, vol. 9, pp. 50
DOI: https://doi.org/10.3390/jcm9010050
Research output: Contribution to Journal › Article (Published)