Patrick Hadoke
Reader
Address
- Street
-
Queens Medical Research Institute
Edinburgh Bioquarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Current research interests
My Research in a Nutshell I am interested in mechanisms that regulate arterial function and structure in health and disease, focussing on the role of the endothelium, new blood vessel formation (angiogenesis), and lesion formation (atherosclerosis, neointimal proliferation). Current research projects address: the potential use of cellular therapies to stimulate angiogenesis in ischaemic tissue; the influence of glucocorticoids on angiogenesis; the role of androgens in regulation of atherosclerosis and angiogenesis; and, the influence of the Wilms' Tumour suppressor on new blood vessel formation. My group uses a combination of in vitro, ex vivo and in vivo techniques to address these topics, with a strong focus on the use of novel imaging techniques to improve analysis.-
11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis
In:
PLoS ONE, vol. 18, pp. e0255709
DOI: https://doi.org/10.1371/journal.pone.0255709
Research output: Contribution to Journal › Article (Published) -
Human embryonic stem cell-derived endothelial cell product injection attenuates cardiac remodeling in myocardial infarction
In:
Frontiers in Cardiovascular Medicine
DOI: https://doi.org/10.3389/fcvm.2022.953211
Research output: Contribution to Journal › Article (Published) -
Comparison of mechanisms of angiostasis caused by the anti-inflammatory steroid 5α-tetrahydrocorticosterone versus conventional glucocorticoids
In:
European Journal of Pharmacology, pp. 175111
DOI: https://doi.org/10.1016/j.ejphar.2022.175111
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The acute pressure natriuresis response is suppressed by selective ETA receptor blockade
In:
Clinical science
DOI: https://doi.org/10.1042/CS20210937
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvab296
Research output: Contribution to Journal › Article (Published) -
Human AdV-20-42-42, a promising novel adenoviral vector for gene therapy and vaccine product development
In:
Journal of Virology
DOI: https://doi.org/10.1128/JVI.00387-21
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Positron Emission Tomography Techniques to Measure Active Inflammation, Fibrosis and Angiogenesis in Hypertensive Heart Failure
In:
Frontiers in Cardiovascular Medicine
DOI: https://doi.org/10.3389/fcvm.2021.719031
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Glucocorticoids: Fuelling the Fire of Atherosclerosis or Therapeutic Extinguishers?
In:
International Journal of Molecular Sciences, vol. 22, pp. 7622
DOI: https://doi.org/10.3390/ijms22147622
Research output: Contribution to Journal › Article (E-pub ahead of print) -
CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318688
Research output: Contribution to Journal › Article (Published) -
Regulatory Role of Sex Hormones in Cardiovascular Calcification
In:
International Journal of Molecular Sciences, vol. 22
DOI: https://doi.org/10.3390/ijms22094620
Research output: Contribution to Journal › Review article (Published) -
MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease
In:
Circulation Research
DOI: https://doi.org/10.1161/CIRCRESAHA.120.318124
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Generation of a Novel In Vitro Model to Study Endothelial Dysfunction from Atherothrombotic Specimens
In:
Cardiovascular Drugs and Therapy
DOI: https://doi.org/10.1007/s10557-021-07151-9
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Characterisation of an atherosclerotic micro-calcification model using ApoE-/- mice and PET/CT
In:
IJC Heart & Vasculature
DOI: https://doi.org/10.1016/j.ijcha.2020.100672
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Assessment of myocardial fibrosis activity using 18F-Fluoroproline Positron Emission Tomography (PET) in rat models of cardiovascular disease
In:
Heart
DOI: https://doi.org/10.1136/heartjnl-2020-SCF.26
Research output: Contribution to Journal › Meeting abstract (Published) -
Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Endothelial Progenitor Cells Do Not Originate From the Bone Marrow
(3 pages)
In:
Circulation, vol. 140, pp. 1524-1526
DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.042351
Research output: Contribution to Journal › Article (Published) -
Human adipose-derived pericytes display steroidogenic lineage potential 2 in vitro and influence leydig cell regeneration in vivo in rats
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-019-50855-0
Research output: Contribution to Journal › Article (Published) -
Non-invasive in vivo imaging of acute thrombosis: development of a novel factor XIIIa radiotracer
In:
European Heart Journal - Cardiovascular Imaging
DOI: https://doi.org/10.1093/ehjci/jez207
Research output: Contribution to Journal › Article (Published) -
Impaired Pressure Natriuresis and Non-Dipping Blood Pressure in Rats with Early Type 1 Diabetes Mellitus: Pressure natriuresis and BP in T1DM
In:
The Journal of Physiology, vol. 597, pp. 767-780
DOI: https://doi.org/10.1113/JP277332
Research output: Contribution to Journal › Article (Published) -
A young testicular microenvironment protects Leydig cells against age‐related dysfunction in a mouse model of premature aging
In:
The FASEB Journal, vol. 33, pp. 978-995
DOI: https://doi.org/10.1096/fj.201800612R
Research output: Contribution to Journal › Article (Published)