Professor Nick Gilbert
Group Leader
- MRC Human Genetics Unit
- Institute of Genetics and Cancer
Contact details
- Tel: 0131 651 8551
- Email: nick.gilbert@ed.ac.uk
Address
- Street
-
MRC Human Genetics Unit
Institute of Genetics and Cancer
The University of Edinburgh
Crewe Road - City
- Edinburgh
- Post code
- EH4 2XU
Background
Nick Gilbert started his research group with a Wellcome Trust Career Development Fellowship (2006-2010) and moved to the MRC Human Genetics Unit in 2012, as an MRC Senior Fellow, where he was awarded a personal chair in Chromatin Biology.
Research Interests: The Gilbert lab develops new tools to investigate how chromatin is folded inside cells, to understand how packaging regulates normal cellular events such as transcription and DNA replication. They also investigate how alterations in chromatin folding can predispose the genome to instability, one of the key drivers for many diseases including cancer. In addition to using cellular models they use synthetic chromatin to gain insight into the molecular mechanisms for regulating chromatin structure.
CV
59120.pdf
Qualifications
BSc. Hons. Biochemistry (1st Class), The University of Edinburgh (1992-1995) Ph.D “Nature and Modulation of the Higher-Order Chromatin Fibre”. Department of Biochemistry and Centre for Genome Research, The University of Edinburgh, UK (1996-2000).
Responsibilities & affiliations
IGC Director of Graduate Research and Training
Wellcome Trust Molecular Basis of Cell Function Expert Review Group
-
Predicting genome organisation and function with mechanistic modelling
(15 pages)
In:
Trends in Genetics, vol. 38, pp. 364-378
DOI: https://doi.org/10.1016/j.tig.2021.11.001
Research output: Contribution to Journal › Review article (Published) -
User acceptability of saliva and gargle samples for identifying COVID-19 positive high-risk workers
DOI: https://doi.org/10.1101/2022.01.28.22270033
Research output: › Preprint (Published) -
Parameter-free Molecular Super-Structures Quantification in Single-Molecule Localisation Microscopy
(15 pages)
In:
Journal of Cell Biology, vol. 220, pp. 1-15
DOI: https://doi.org/10.1083/jcb.202010003
Research output: Contribution to Journal › Article (Published) -
cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing
(9 pages)
In:
Nature Genetics, vol. 52, pp. 1364-1372
DOI: https://doi.org/10.1038/s41588-020-00737-3
Research output: Contribution to Journal › Article (Published) -
A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection
In:
PLoS Biology, vol. 18, pp. e3001030
DOI: https://doi.org/10.1371/journal.pbio.3001030
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Common fragile sites are characterised by faulty condensin loading after replication stress
In:
Cell Reports
DOI: https://doi.org/10.1016/j.celrep.2020.108177
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mechanistic modeling of chromatin folding to understand function
In:
Nature Methods
DOI: https://doi.org/10.1038/s41592-020-0852-6
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Centromere chromatin structure - Lessons from neocentromeres
In:
Experimental Cell Research, pp. 111899
DOI: https://doi.org/10.1016/j.yexcr.2020.111899
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Negative supercoil at gene boundaries modulates gene topology
(5 pages)
In:
Nature, vol. 577, pp. 701–705
DOI: https://doi.org/10.1038/s41586-020-1934-4
Research output: Contribution to Journal › Article (Published) -
Large-scale chromatin organisation in interphase, mitosis and meiosis
(16 pages)
In:
Biochemical Journal, vol. 476, pp. 2141-2156
DOI: https://doi.org/10.1042/BCJ20180512
Research output: Contribution to Journal › Review article (Published)