Nicholas Morton
Personal Chair of Molecular Metabolism
Address
- Street
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The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh BioQuarter
- City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
I am interested in how our genes predipose us to, or protect us from, the adverse metabolic effects of the modern "obesogenic lifestyle". I believe understanding the intrinsic mechanisms that allow some people to remain lean, healthy and age successfully despite the "onslaught of plenty" will illuminate new therapeutic avenues for metabolic dysfunction and its associated diseases.https://media.ed.ac.uk/media/1_2ke22jg1
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The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
In:
eLIFE
DOI: https://doi.org/10.7554/eLife.88080
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-022-35563-0
Research output: Contribution to Journal › Article (Published) -
Genome-wide screening for genetic variants in polyadenylation signal (PAS) sites in mouse selection lines for fatness and leanness
In:
Mammalian Genome
DOI: https://doi.org/10.1007/s00335-022-09967-8
Research output: Contribution to Journal › Article (Published) -
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes
In:
Acs chemical biology
DOI: https://doi.org/10.1021/acschembio.2c00301
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent
DOI: https://doi.org/10.1101/2022.02.20.481222
Research output: › Preprint (Published) -
Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy
(18 pages)
In:
Nature Communications, vol. 13
DOI: https://doi.org/10.1038/s41467-021-27869-2 |
Research output: Contribution to Journal › Article (Published) -
The Hepatic Compensatory Response to Elevated Systemic Sulfide Promotes Diabetes
In:
Cell Reports
DOI: https://doi.org/10.1016/j.celrep.2021.109958
Research output: Contribution to Journal › Article (Published) -
TDP-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model
In:
Brain Communications, vol. 3
DOI: https://doi.org/10.1093/braincomms/fcab255
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes
In:
The Journal of Physiology
DOI: https://doi.org/10.1113/JP281860
Research output: Contribution to Journal › Article (Published) -
Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress
In:
Epigenetics and Chromatin
DOI: https://doi.org/10.1186/s13072-021-00405-8
Research output: Contribution to Journal › Article (E-pub ahead of print) -
JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells
(11 pages)
In:
Blood Advances, vol. 5, pp. 889-899
DOI: https://doi.org/10.1182/bloodadvances.2020002702
Research output: Contribution to Journal › Article (Published) -
A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis
In:
iScience, vol. 24
DOI: https://doi.org/10.1016/j.isci.2020.101931
Research output: Contribution to Journal › Article (Published) -
Fibroblast Growth Factor 7 Releasing Particles Enhance Islet Engraftment and Improve Metabolic Control Following Islet Transplantation in Mice with Diabetes
In:
American Journal of Transplantation
DOI: https://doi.org/10.1111/ajt.16488
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis
In:
Acta Neuropathologica
DOI: https://doi.org/10.1007/s00401-020-02252-5
Research output: Contribution to Journal › Article (Published) -
Osteoblast-specific deficiency of ectonucleotide pyrophosphatase or phosphodiesterase-1 engenders insulin resistance in high-fat diet fed mice
In:
Journal of Cellular Physiology
DOI: https://doi.org/10.1002/jcp.30194
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Ablation of Enpp6 results in transient bone hypomineralization
In:
JBMR Plus
DOI: https://doi.org/10.1002/jbm4.10439
Research output: Contribution to Journal › Article (E-pub ahead of print) -
PHOSPHO1 is a skeletal regulator of insulin resistance and obesity
(20 pages)
In:
BMC Biology, vol. 18
DOI: https://doi.org/10.1186/s12915-020-00880-7
Research output: Contribution to Journal › Article (Published) -
Substrate utilisation by brown adipose tissue: what’s hot and what’s not?
In:
Frontiers in Endocrinology
DOI: https://doi.org/10.3389/fendo.2020.571659
Research output: Contribution to Journal › Review article (E-pub ahead of print) -
Enhanced axonal response of mitochondria to demyelination offers neuroprotection: Implications for multiple sclerosis
(24 pages)
In:
Acta Neuropathologica, vol. 140, pp. 143–167
DOI: https://doi.org/10.1007/s00401-020-02179-x
Research output: Contribution to Journal › Article (Published) -
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis
In:
Nature Communications, vol. 11
DOI: https://doi.org/10.1038/s41467-020-16878-2
Research output: Contribution to Journal › Article (Published)