Professor Neil Mabbott
Personal Chair of Immunopathology
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Availability
Willingness to take Ph.D. students: Yes
Background
1989-1992 BSc (Hons) Microbiology, University of Leeds, UK
1992-1995 PhD Immunoparasitology, University of Aberdeen, UK
1995-2003 Post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh
2003-2005 Senior post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh
2006-2007 Principal scientist, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh
2007-2009 Principal scientist, The Roslin Institute, Edinburgh, UK
2009-2015 Reader, The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK
2015-present Professor, Personal Chair in Immunopathology, The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK
Qualifications
Doctor of Philosophy (PhD), University of Aberdeen, Nitric oxide, friend or foe during trypanosomiasis?
Bachelor of Science (BSc hons), Microbiology, University of Leeds
Research summary
Host-pathogen interactions in the mucosal immune system.
Current research interests
My research aims to understand the pathogenesis of infectious diseases within the immune system. Particular interests include understanding host-pathogen interactions within the mucosal immune system, especially prion diseases and other gastrointestinal pathogens such as Salmonella and nematodes. Studies are also focused on the effects of host age on the function of the immune system and how this influences susceptibility to gastrointestinal pathogens. A systems biology approach is also being used to compare the transcriptomic profiles of distinct immune cell populations in the steady-state, and also during ageing. This research benefits greatly from the availability of precisely defined mouse prion pathogenesis models, unique transgenic and immunodeficient mice and state-of-the-art bio-imaging and bioinformatics expertise.-
The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection: Functional characterisation of the murine meninges during chronic infections
DOI: https://doi.org/10.1101/2023.04.30.538710
Research output: › Working paper (E-pub ahead of print) -
Temporal transcriptome profiling of floating apical out chicken enteroids suggests stability and reproducibility
(16 pages)
In:
Veterinary Research, vol. 54, pp. 1-16
DOI: https://doi.org/10.1186/s13567-023-01144-2
Research output: Contribution to Journal › Article (Published) -
Defining the pig microglial transcriptome reveals its core signature, regional heterogeneity, and similarity with human and rodent microglia: Pig microglial transcriptome signature
In:
Glia, vol. 71, pp. 334-349
DOI: https://doi.org/10.1002/glia.24274
Research output: Contribution to Journal › Article (Published) -
Prions and Diseases: Transgenic Mice Modelling in Prion Diseases
DOI: https://doi.org/10.1007/978-3-031-20565-1_15
Research output: › Chapter (peer-reviewed) (Published) -
Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain: Microglia and prion disease
(53 pages)
In:
Glia, vol. 70, pp. 2169-2187
DOI: https://doi.org/10.1002/glia.24244
Research output: Contribution to Journal › Article (Published) -
Single cell and spatial transcriptomic reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection
In:
Nature Communications, vol. 13
DOI: https://doi.org/10.1038/s41467-022-33542-z
Research output: Contribution to Journal › Article (Published) -
The Development of 3D Bovine Intestinal Organoid Derived Models to Investigate Mycobacterium Avium ssp Paratuberculosis Pathogenesis
In:
Frontiers in Veterinary Science, vol. 9
DOI: https://doi.org/10.3389/fvets.2022.921160
Research output: Contribution to Journal › Article (Published) -
Development of bovine abomasal organoids as a novel in-vitro model to study host-parasite interactions in gastrointestinal nematode infections
In:
Frontiers in Cellular and Infection Microbiology, vol. 12, pp. 1-20
DOI: https://doi.org/10.3389/fcimb.2022.904606
Research output: Contribution to Journal › Article (Published) -
Innate immune tolerance in microglia does not impact on CNS prion disease
In:
Frontiers in Cellular Neuroscience, vol. 16, pp. 1-14
DOI: https://doi.org/10.3389/fncel.2022.918883
Research output: Contribution to Journal › Article (Published) -
Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1)
(27 pages)
In:
PLoS Pathogens, vol. 1009942, pp. 1 - 27
DOI: https://doi.org/10.1371/journal.ppat.1009942
Research output: Contribution to Journal › Article (Published)