Professor Neil Mabbott
Personal Chair of Immunopathology
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Availability
Willingness to take Ph.D. students: Yes
Background
1989-1992 BSc (Hons) Microbiology, University of Leeds, UK
1992-1995 PhD Immunoparasitology, University of Aberdeen, UK
1995-2003 Post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh
2003-2005 Senior post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh
2006-2007 Principal scientist, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh
2007-2009 Principal scientist, The Roslin Institute, Edinburgh, UK
2009-2015 Reader, The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK
2015-present Professor, Personal Chair in Immunopathology, The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK
Qualifications
Doctor of Philosophy (PhD), University of Aberdeen, Nitric oxide, friend or foe during trypanosomiasis?
Bachelor of Science (BSc hons), Microbiology, University of Leeds
Research summary
Host-pathogen interactions in the mucosal immune system.
Current research interests
My research aims to understand the pathogenesis of infectious diseases within the immune system. Particular interests include understanding host-pathogen interactions within the mucosal immune system, especially prion diseases and other gastrointestinal pathogens such as Salmonella and nematodes. Studies are also focused on the effects of host age on the function of the immune system and how this influences susceptibility to gastrointestinal pathogens. A systems biology approach is also being used to compare the transcriptomic profiles of distinct immune cell populations in the steady-state, and also during ageing. This research benefits greatly from the availability of precisely defined mouse prion pathogenesis models, unique transgenic and immunodeficient mice and state-of-the-art bio-imaging and bioinformatics expertise.-
Aging-related impairments to M cells in Peyer's patches coincide with disturbances to Paneth cells
In:
Frontiers in Immunology, vol. 12
DOI: https://doi.org/10.3389/fimmu.2021.761949
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability
In:
Cells, vol. 10
DOI: https://doi.org/10.3390/cells10123403
Research output: Contribution to Journal › Article (Published) -
Corrigendum: To the Skin and Beyond: The Immune Response to African Trypanosomes as They Enter and Exit the Vertebrate Host
In:
Frontiers in Immunology, vol. 12
DOI: https://doi.org/10.3389/fimmu.2021.780758
Research output: Contribution to Journal › Comment/debate (Published) -
Foot-and-mouth disease virus localisation on follicular dendritic cells and sustained induction of neutralising antibodies is dependent on binding to complement receptors (CR2/CR1)
DOI: https://doi.org/10.1101/2021.09.08.459380
Research output: › Working paper (Published) -
The clinical correlates of vaccine-induced immune thrombotic thrombocytopenia after immunization with adenovirus vector based SARS-CoV-2 vaccines
In:
Immunotherapy Advances , vol. 1
DOI: https://doi.org/10.1093/immadv/ltab019
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Dermal bacterial LPS-stimulation reduces susceptibility to intradermal Trypanosoma brucei infection
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-021-89053-2
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Complete microglia deficiency accelerates prion disease without enhancing CNS prion accumulation
Research output: Contribution to Conference › Poster (Published) -
The Role of Microglia in CNS Innate Immune Memory
Research output: Contribution to Conference › Poster (Published) -
Inside-Out Chicken Enteroids with Leukocyte Component as a Model to Study Host-Pathogen Interactions
In:
Communications biology
DOI: https://doi.org/10.1038/s42003-021-01901-z
Research output: Contribution to Journal › Article (Published) -
Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging
In:
Nature Aging
DOI: https://doi.org/10.1038/s43587-020-00010-6
Research output: Contribution to Journal › Article (Published)