Morwenna Muir (BSc (Hons) Computing and IT (Software))
Senior Technical Officer
- Institute of Genetics and Cancer, Edinburgh Cancer Research Centre
Contact details
- Tel: +44 (0)131 537 2002
- Email: mmuir1@ed.ac.uk
Address
- Street
-
Biomedical Research Facility
Western General Hospital
Crewe Road South - City
- Edinburgh
- Post code
- EH4 2XU
Availability
Monday - Friday 07.30 - 15.30
Background
Morwenna is a Senior Technical Officer in the Institute of Genetics and Cancer, Brunton Group, performing research on signalling and the regulation of cancer growth and metastasis. In addition to her primary research focus, Morwenna supports research groups across the Edinburgh Cancer Centre using a variety of in vivo techniques.
Morwenna joined the University in 1981 as an animal technician in the Department of Pharmacology, and transferred to the Western General Campus in 1990, as a technician for the Imperial Cancer Research Fund, later Cancer Research UK. She joined the Brunton Group in 2009.
Qualifications
BSc (Hons) Computing and IT (Software)
-
Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models
In:
eLIFE, vol. 12
DOI: https://doi.org/10.7554/eLife.85739
Research output: Contribution to Journal › Article (Published) -
11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis
In:
PLoS ONE, vol. 18, pp. e0255709
DOI: https://doi.org/10.1371/journal.pone.0255709
Research output: Contribution to Journal › Article (Published) -
Toll-like receptor orchestrates a tumor suppressor response in non-small cell lung cancer
In:
Cell Reports
DOI: https://doi.org/10.1016/j.celrep.2022.111596
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Myc sensitises cells to apoptosis by driving energetic demand
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-022-32368-z
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Analysis of Pancreatic Acinar Protein Solubility in Autophagy-Deficient Mice
(11 pages)
DOI: https://doi.org/10.1007/978-1-0716-2071-7_15
Research output: › Chapter (Published) -
Loss of Integrin-linked kinase sensitizes breast cancer to SRC inhibitors
In:
Cancer Research
DOI: https://doi.org/10.1158/0008-5472.CAN-21-0373
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence
In:
Cell Death & Differentiation (CDD)
DOI: https://doi.org/10.1038/s41418-021-00917-6
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Pathway profiling of a novel SRC inhibitor, AZD0424, in combination with MEK inhibitors
In:
Molecular Oncology
DOI: https://doi.org/10.1002/1878-0261.13151
Research output: Contribution to Journal › Article (E-pub ahead of print) -
ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling
In:
Oncogene
DOI: https://doi.org/10.1038/s41388-021-02017-8
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability
In:
Cancer Research
DOI: https://doi.org/10.1158/0008-5472.CAN-21-0613
Research output: Contribution to Journal › Article (E-pub ahead of print) -
A synergistic anti-cancer FAK and HDAC inhibitor combination discovered by a novel chemical-genetic high-content phenotypic screen
(13 pages)
In:
Molecular Cancer Therapeutics, vol. 19, pp. 637–649
DOI: https://doi.org/10.1158/1535-7163.MCT-19-0330
Research output: Contribution to Journal › Article (Published) -
Evaluation of the dual mTOR / PI3K inhibitors Gedatolisib (PF-05212384) and PF-04691502 against ovarian cancer xenograft models
In:
Scientific Reports
DOI: https://doi.org/10.1038/s41598-019-55096-9
Research output: Contribution to Journal › Article (E-pub ahead of print) -
HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies
In:
Breast cancer research and treatment
DOI: https://doi.org/10.1007/s10549-019-05489-1
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Development of mouse models of angiosarcoma driven by p53
In:
Disease Models and Mechanisms, vol. 12
DOI: https://doi.org/10.1242/dmm.038612
Research output: Contribution to Journal › Article (Published) -
The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype
(14 pages)
In:
Science Advances, vol. 5
DOI: https://doi.org/10.1126/sciadv.aaw0254
Research output: Contribution to Journal › Article (Published) -
Kindlin-1 regulates the mammary tumour cell secretome
DOI: https://doi.org/10.1111/iep.2018.99.issue-6
Research output: Contribution to Conference › Abstract (Published) -
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
(9 pages)
In:
Nature, vol. 559, pp. 285–289
DOI: https://doi.org/10.1038/s41586-018-0291-z
Research output: Contribution to Journal › Article (Published) -
Kindlin-1 promotes pulmonary breast cancer metastasis
(13 pages)
In:
Cancer Research, vol. 78, pp. 1484-1496
DOI: https://doi.org/10.1158/0008-5472.CAN-17-1518
Research output: Contribution to Journal › Article (E-pub ahead of print) -
WT1 expression in breast cancer disrupts the epithelial/mesenchymal balance of tumour cells and correlates with the metabolic response to docetaxel
In:
Scientific Reports, vol. 7
DOI: https://doi.org/10.1038/srep45255
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The role of Kindlin-1 in the initiation and progression of breast cancer
DOI: https://doi.org/10.1007/s10549-016-3898-5
Research output: › Abstract (Published)