Mattias Malaguti (AFHEA)
Senior Researcher
Contact details
- Tel: 0131 651 9500
- Email: mattias.malaguti@ed.ac.uk
Address
- Street
-
Centre for Regenerative Medicine
Institute for Regeneration and Repair
The University of Edinburgh
Edinburgh BioQuarter
5 Little France Drive - City
- Edinburgh
- Post code
- EH16 4UU
Undergraduate teaching
2021: Biotechnology 3 (Tutor)
2020-2021: Developmental Biology 3 (Demonstrator, Marker)
2019-2020: Quantitative Skills for Biologists 1 (Tutor)
Postgraduate teaching
2022: Tissue Repair MScR cohort (Interactive Lecture/Discussion Group)
2019: Tissue Repair PhD/MSc cohort (Interactive Lecture/Discussion Group)
2014-2022: Supervision of PhD research students (Member/Convener of Thesis Committee)
Research summary
What regulates cell state transitions? Which processes and players are involved?
My work has focused on analysing how feedbacks between signalling molecules, gene regulatory networks and adhesion molecules stabilise transitions between cell states in early mouse development (Malaguti et al. 2019, Malaguti et al. 2013, Rao et al. 2020, Punovuori et al. 2019, Zhou et al. 2013). In Malaguti et al. 2019, I characterised a mechanism that confers robustness to early developmental events by rendering cells deaf to specific signalling cues during a narrow developmental time window. I am now interested in understanding whether a similar mechanism could be operating in other developmental contexts, and whether it may regulate the initiation and progression of malignancy.
It has long been known that the behaviour of one cell can affect that of its neighbours, but we have until recently lacked tools to interrogate this process at high spatial and temporal resolution. I have recently developed a modular synthetic system to monitor and manipulate cell-cell interactions in clonal mouse pluripotent stem cell lines (Malaguti et al. 2021). I plan to use this system to study how cell-cell communication can influence cell fate decisions in development and in disease.
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Cadherins in early neural development
(16 pages)
In:
Cellular and Molecular Life Sciences
DOI: https://doi.org/10.1007/s00018-021-03815-9
Research output: Contribution to Journal › Review article (Published) -
The transcription factor E2A drives neural differentiation in pluripotent cells
In:
Development, vol. 147
DOI: https://doi.org/10.1242/dev.184093
Research output: Contribution to Journal › Article (Published) -
N-cadherin stabilises neural identity by dampening anti-neural signals
In:
Development, vol. 146
DOI: https://doi.org/10.1242/dev.183269
Research output: Contribution to Journal › Article (Published) -
Id1 stabilises epiblast identity by sensing delays in nodal activation and adjusting the timing of differentiation
(16 pages)
In:
Developmental Cell, vol. 50, pp. 462-477.E
DOI: https://doi.org/10.1016/j.devcel.2019.05.032
Research output: Contribution to Journal › Article (Published) -
Bone Morphogenic Protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin
(20 pages)
In:
eLIFE, vol. 2
DOI: https://doi.org/10.7554/eLife.01197
Research output: Contribution to Journal › Article (Published) -
Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity
(12 pages)
In:
STEM CELLS, vol. 31, pp. 1511-1522
DOI: https://doi.org/10.1002/stem.1426
Research output: Contribution to Journal › Article (Published)