Mr Maciej Parys
Vet Clinical Lectureship
Contact details
Address
- Street
-
The Royal (Dick) School of Veterinary Studies and The Roslin Institute
Easter Bush
Midlothian - City
- Post code
- EH25 9RG
Background
I have graduated from University of Warmia and Mazury in Olsztyn, Poland in 2009. Subsequently I worked in private practice. In 2010 I have started PhD at Michigan State University, College of Veterinary Medicine. During my PhD I was studying immunomodulatory properties of feline mesenchymal stem cells and their clinical application in chronic feline idiopathic cystitis. In 2016 I relocated to R(D)SVS to start a clinical lecturership position, which combines work in small animal internal medicine with research on identifying novel approaches to cancer immunotherapy. My research interests also include therapeutic use of stem cells in companion animals, use of next generation sequencing to identify disease causing genetic variants and pathways involved in disease pathogenesis in companion animals. In 2016 I was awarded an AVMA/AVMF Young Investigator Award for work on immunomodulatory properties of feline mesenchymal stem cells. In 2017 I was awarded an ABCD and Boeringher Ingelheim Young Scientist Award.
Qualifications
2010 Doctor of Philosophy (PhD), Michigan State University Evaluation of immunomodulatory properties of feline mesenchymal stem cells and their clinical application in treatment of feline chronic idiopathic cystitis
2004 University of Warmia and Mazury
Research summary
My current research interests include studying the role of immune checkpoints in canine and feline cancer and inflammatory disease. I am also intereted in interactions between innate and adaptive immune system in cancer patients.
Current research interests
Cancer immunotherapy, therapeutic use of mesenchymal stem cells, immunology, personalized medicine, use of next generation sequencing to identify disease causing variants and pathwaysResearch activities
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The immunopeptidome from a genomic perspective: Establishing the noncanonical landscape of MHC class I–associated peptides
(39 pages)
In:
Cancer Immunology Research, pp. 1-40
DOI: https://doi.org/10.1158/2326-6066.CIR-22-0621
Research output: Contribution to Journal › Article (E-pub ahead of print) -
TGF-β induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease
(23 pages)
In:
Cell proliferation, pp. 1-23
DOI: https://doi.org/10.1111/cpr.13435
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Use of multi-color flow cytometry for canine immune cell characterization in cancer
(15 pages)
In:
PLoS ONE, vol. 18, pp. 1-15
DOI: https://doi.org/10.1371/journal.pone.0279057
Research output: Contribution to Journal › Article (Published) -
Development of monoclonal antibodies targeting canine PD-L1 and PD-1 and their clinical relevance in Canine Apocrine Gland Anal Sac Adenocarcinoma
In:
Cancers, vol. 14
DOI: https://doi.org/10.3390/cancers14246188
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Design, synthesis and biological evaluation of PD-1 derived peptides as inhibitors of PD-1/PD-L1 complex formation for cancer therapy
In:
Bioorganic Chemistry, vol. 128, pp. 1-15
DOI: https://doi.org/10.1016/j.bioorg.2022.106047
Research output: Contribution to Journal › Article (Published) -
Identification of a Hypomorphic FANCG Variant in Bernese Mountain Dogs
In:
Genes, vol. 13
DOI: https://doi.org/10.3390/genes13101693
Research output: Contribution to Journal › Article (Published) -
Comparison of manufacturer-prescribed and patient-centric CT-table heights for computed tomographic bone mineral density assessment.
Research output: Contribution to Conference › Poster (E-pub ahead of print) -
A simplified and accurate CT-volumetry method for the canine liver
In:
Veterinary Radiology & Ultrasound, vol. 63, pp. 47-53
DOI: https://doi.org/10.1111/vru.13018
Research output: Contribution to Journal › Article (Published) -
CT features of feline lipiduria and renal cortical lipid deposition
In:
Journal of Feline Medicine and Surgery, vol. 23, pp. 357-363
DOI: https://doi.org/10.1177/1098612X20957161
Research output: Contribution to Journal › Article (Published) -
Four dimensional CT excretory Urography as an Accurate Technique for Diagnosis of Canine Ureteral Ectopia
In:
Veterinary Radiology & Ultrasound, vol. 62, pp. 190-198
DOI: https://doi.org/10.1111/vru.12934
Research output: Contribution to Journal › Article (Published)