Louise Stephen
BBSRC Discovery Fellow
Contact details
- Tel: +44 (0)131 651 9120
- Email: louise.stephen@roslin.ed.ac.uk
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Background
I'm a developmental biologist who wants to know how tissues mineralise. I use fluorescent markers in bones and scales to track mineralisation on the subcellular scale using cool imaging techniques along the way! I have studied protein localisation in chicken, mouse, fish and cells to better understand signalling and development in ciliopathies and immunology at The University of Manchester, CRUK Beatson Institute and here at The Roslin Institute. I moved to The Roslin Institute in 2019 and translated this background to better understand bone disorders and mineralisation in mouse and human bone. In 2022 I was awarded a BBSRC Discovery Fellowship to translate this work into fish scales and wound healing in aquaculture. I am developing tools to better understand the mechanisms underpinning mineralisation, using scales as a model system. I use zebrafish, salmon and tilapia in my research.
Qualifications
BSc(hons) Genetics University of Manchester
MRes (Biological Sciences) University of Manchester
PhD Developmental Biology University of Manchester
Responsibilities & affiliations
Bone Research Society Committee Member
Bone Research Seminars Founder
Scottish Microscopy Society Committee Member
HR Excellence in Research Awards Panel Member
UK Research Staff Association Former Chair
British Society of Developmental Biologists
Undergraduate teaching
BVM&S Animal Body 1
Current PhD students supervised
Charlotte Clews - Investigating matrix vesicle biogenesis and their roles in bone mineralisation
Worachet Promruk - Understanding the balance between osteogenesis and adipogenesis in a mouse model of chronic kidney disease
Past PhD students supervised
Shun-Neng Hsu - Mechanisms underpinning chronic kidney disease-mineral and bone disorder Graduated 2022
Current research interests
Biomineralisation Cytoskeletal organisation Protein traffickingPast research interests
Cilia and ciliopathies Conservation of trafficking pathways Cardiac developmentKnowledge exchange
I am the founder of an internationally recognised seminar series, established to improve visibility of ECRs and provide open access to cutting edge research weekly during the 2020 Covid19 Lockdown.
I promote Scottish microscopy as a member of the Scottish Microscopy Society and have spearheaded a programme to bring microscopes to schools across the region in collaboration with Easter Bush Science Outreach Centre via my project 'Wee Box of Wonders'.
Current project grants
BBSRC Discovery Fellowship £506,473
Past project grants
ISP Pump-Priming Grant. Co-investigator. £ 24,223.13
Duchenne Parent Project – Small Project Grant. Co-investigator. €25,000
LifeArc & Chief Scientist Office (CSO) Translational Research. Co-investigator. £99,445.
Roslin Institute ISP Early Career Grant. Principal Investigator. £1,800
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Spatial lipidomic profiling of mouse joint tissue demonstrates the essential role of PHOSPHO1 in growth plate homeostasis: Spatially resolving the joint lipidome
In:
Journal of Bone and Mineral Research, vol. 38, pp. 792-807
DOI: https://doi.org/10.1002/jbmr.4796
Research output: Contribution to Journal › Article (Published) -
Increased PHOSPHO1 and Alkaline Phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery: Control of PHOSPHO1 and TNAP expression by iPTH
In:
Cell Biochemistry and Function, pp. 1-13
DOI: https://doi.org/10.1002/cbf.3772
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy
In:
Journal of Endocrinology, vol. 254, pp. 153-167
DOI: https://doi.org/10.1530/JOE-22-0097
Research output: Contribution to Journal › Article (Published)