Linda Mullins
Research Fellow
Address
- Street
-
Queens Medical Research Institute
Edinburgh Bioquarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
Over the last 25 years I have been involved in the generation and characterisation of transgenic mouse and rat models - using microinjection with BACs, ES cell gene knock-out and blastocyst injection, and more recently using genome engineering with ZFN and CRISPR-Cas9 technologies. Gene targets have included renin, 11 B-hydroxylase and hydroxysteroid dehydrogenase type 2. The models have been extensively characterised for renal function, blood pressure and aspects of metabolism. I am currently planning CRISPR-Cas 9 targeting experiments in zebrafish