Linda Mullins
Research Fellow
Address
- Street
-
Queens Medical Research Institute
Edinburgh Bioquarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
Over the last 25 years I have been involved in the generation and characterisation of transgenic mouse and rat models - using microinjection with BACs, ES cell gene knock-out and blastocyst injection, and more recently using genome engineering with ZFN and CRISPR-Cas9 technologies. Gene targets have included renin, 11 B-hydroxylase and hydroxysteroid dehydrogenase type 2. The models have been extensively characterised for renal function, blood pressure and aspects of metabolism. I am currently planning CRISPR-Cas 9 targeting experiments in zebrafish
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Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat
(910 pages)
In:
Pflügers Archiv European Journal of Physiology, pp. 897
DOI: https://doi.org/10.1007/s00424-021-02582-7
Research output: Contribution to Journal › Article (Published) -
scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain
In:
Cellular Physiology and Biochemistry
DOI: https://doi.org/10.33594/000000366
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Loss of Adam10 disrupts ion transport in immortalised kidney collecting duct cells
In:
Function
DOI: https://doi.org/10.1093/function/zqab024
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Cellular plasticity: a mechanism for homeostasis in the kidney
In:
Acta Physiologica
DOI: https://doi.org/10.1111/apha.13447
Research output: Contribution to Journal › Article (Published) -
Investigating the RAS can be a fishy business: Interdisciplinary opportunities using Zebrafish
In:
Clinical science
DOI: https://doi.org/10.1042/CS20180721
Research output: Contribution to Journal › Article (E-pub ahead of print) -
mCCDcl1 cells show Plasticity Consistent with the Ability to Transition between Principal and Intercalated Cells
In:
American Journal of Physiology - Renal Physiology
DOI: https://doi.org/10.1152/ajprenal.00354.2017
Research output: Contribution to Journal › Article (Published) -
Phenotypic dissection of the mouse Ren-1(d) knockout by complementation with human renin
In:
Journal of Biological Chemistry
DOI: https://doi.org/10.1074/jbc.RA117.000160
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Transcription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses
In:
Endocrine connections
DOI: https://doi.org/10.1530/EC-17-0092
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Zebrafish mesonephric renin cells are functionally conserved and comprise of two distinct morphological populations
In:
American Journal of Physiology - Renal Physiology, vol. 312, pp. ajprenal.00608.2016
DOI: https://doi.org/10.1152/ajprenal.00608.2016
Research output: Contribution to Journal › Article (Published) -
Characterisation of a Mouse Kidney Cortical Collecting Duct Cell Line Suggests Plasticity Between Cell Types
Research output: Contribution to Conference › Abstract (Published) -
Renal disease pathophysiology and treatment: contributions from the rat
(15 pages)
In:
Disease Models and Mechanisms, vol. 9, pp. 1419-1433
DOI: https://doi.org/10.1242/dmm.027276
Research output: Contribution to Journal › Literature review (E-pub ahead of print) -
Renin expression in developing zebrafish is associated with angiogenesis and requires the Notch pathway and endothelium
In:
American Journal of Physiology - Renal Physiology, vol. 309, pp. F531-F539
DOI: https://doi.org/10.1152/ajprenal.00247.2015
Research output: Contribution to Journal › Article (Published) -
Mineralocorticoid Excess or Glucocorticoid Insufficiency: Renal and Metabolic Phenotypes in a Rat Hsd11b2 Knockout Model
In:
Hypertension, vol. 66
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.115.05262
Research output: Contribution to Journal › Article (Published) -
Hypertrophy in the Distal Convoluted Tubule of an 11β-Hydroxysteroid Dehydrogenase Type 2 Knockout Model
In:
Journal of the American Society of Nephrology, vol. 26, pp. 1537-1548
DOI: https://doi.org/10.1681/ASN.2013060634
Research output: Contribution to Journal › Article (Published) -
Syndrome of apparent mineralocorticoid excess: rat model
(1 page)
In:
Transgenic Research, vol. 23, pp. 878-878
Research output: Contribution to Journal › Meeting abstract (Published) -
Complementation of juxtaglomerular cell granulation in Ren-1d null mice by human renin
(1 page)
In:
The FASEB Journal, vol. 27
Research output: Contribution to Journal › Meeting abstract (Published) -
Activation of Thiazide-Sensitive Co-Transport by Angiotensin II in the cyp1a1-Ren2 Hypertensive Rat
In:
PLoS ONE, vol. 7, pp. e36311
DOI: https://doi.org/10.1371/journal.pone.0036311
Research output: Contribution to Journal › Article (Published) -
Uterine cell turnover in a mouse model of adenomyosis caused by congenital adrenal hyperplasia
(1 page)
In:
Endocrine Abstracts, vol. 28, pp. P290
Research output: Contribution to Journal › Meeting abstract (Published) -
Transcriptional and physiological responses to chronic ACTH treatment by the mouse kidney
(9 pages)
In:
Physiological Genomics, vol. 40, pp. 158-166
DOI: https://doi.org/10.1152/physiolgenomics.00088.2009
Research output: Contribution to Journal › Article (Published) -
Physiological and pathophysiological applications of sensitive ELISA methods for urinary deoxycorticosterone and corticosterone in rodents
(7 pages)
In:
Steroids, vol. 74, pp. 938-944
DOI: https://doi.org/10.1016/j.steroids.2009.06.009
Research output: Contribution to Journal › Article (Published)