Lee Murphy
Genetics Manager
- Genetics Core
- Edinburgh Clinical Research Facility
Contact details
- Tel: 0131 537 2591
- Email: Lee.Murphy@ed.ac.uk
- @LeeMurphyCRF
Address
- Street
-
Edinburgh Clinical Research Facility
Wellcome Trust CRF Building
University of Edinburgh
Western General Hospital - City
- Edinburgh
- Post code
- EH4 2XU
Background
I am Head of the Genetics Core at the Edinburgh Clinical Research Facility. This is a joint University of Edinburgh and NHS Lothian facility for conducting multidisciplinary clinical research. My team of expert technicians provides support to studies investigating the role of genetics in disease and health. The laboratory provides sample processing, biobanking and high-throughput genomics with quality systems in place to ensure processes are conducted in accordance with clinical trial legislation.
I am a member of the University Technician Steering Commitee leading on the development and implementation of the national Technician Commitment action plan. The University has over a thousand highly trained and experienced individuals with diverse skills working across all subject areas. These technical staff play an important, but often overlooked role in research, teaching and supporting our students.
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CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages
(17 pages)
In:
Science Advances, vol. 9, pp. 1-17
DOI: https://doi.org/10.1126/sciadv.adg5128
Research output: Contribution to Journal › Article (E-pub ahead of print) -
GWAS and meta-analysis identifies 49 genetic variants underlying critical Covid-19
(30 pages)
In:
Nature, vol. 617, pp. 763-793
DOI: https://doi.org/10.1038/s41586-023-06034-3
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Development and validation of DNA Methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes
In:
Nature Aging
DOI: https://doi.org/10.1038/s43587-023-00391-4
Research output: Contribution to Journal › Article (Published) -
Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders
(17 pages)
In:
Brain, Behavior, and Immunity, vol. 110, pp. 322-338
DOI: https://doi.org/10.1016/j.bbi.2023.03.011
Research output: Contribution to Journal › Article (Published) -
Refining epigenetic prediction of chronological and biological age
In:
Genome Medicine, vol. 15
DOI: https://doi.org/10.1186/s13073-023-01161-y
Research output: Contribution to Journal › Article (Published)