John Mullins
Personal Chair of Molecular Physiology
Address
- Street
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The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh BioQuarter
- City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
My research focusses on the molecular and cellular mechanisms that regulate blood pressure. We use molecular, cellular and in vivo tools, including state-of-the-art imaging and genetic techniques to understand how key genes work, to dissect pathways through which they operate, and to understand the function of specialized cells that secrete hormones and control fluid and salt balance.
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Sex Difference in Renal Artery Contractility in a Novel CRISPR/Cas9-Generated P2X7 Knockout Rat
(1 page)
In:
The FASEB Journal, vol. 36
DOI: https://doi.org/10.1096/fasebj.2022.36.S1.R5740
Research output: Contribution to Journal › Meeting abstract (Published) -
Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish
In:
Development
DOI: https://doi.org/10.1242/dev.199636
Research output: Contribution to Journal › Article (Published) -
Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat
(910 pages)
In:
Pflügers Archiv European Journal of Physiology, pp. 897
DOI: https://doi.org/10.1007/s00424-021-02582-7
Research output: Contribution to Journal › Article (Published) -
scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain
In:
Cellular Physiology and Biochemistry
DOI: https://doi.org/10.33594/000000366
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Loss of Adam10 disrupts ion transport in immortalised kidney collecting duct cells
In:
Function
DOI: https://doi.org/10.1093/function/zqab024
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Transcription factor Pit-1 affects transcriptional timing in the dual-promoter human prolactin gene
In:
Endocrinology, vol. 162
DOI: https://doi.org/10.1210/endocr/bqaa249
Research output: Contribution to Journal › Article (Published) -
Live imaging of the immune response to heart injury in larval zebrafish reveals a multi-stage model of neutrophil and macrophage migration
In:
Frontiers in Cell and Developmental Biology, vol. 8
DOI: https://doi.org/10.3389/fcell.2020.579943
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Endothelin-1 mediates the systemic and renal hemodynamic effects of GPR81 activation
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.119.14308
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Cellular plasticity: a mechanism for homeostasis in the kidney
In:
Acta Physiologica
DOI: https://doi.org/10.1111/apha.13447
Research output: Contribution to Journal › Article (Published) -
Adaptive prospective optical gating enables day-long 3D time-lapse imaging of the beating embryonic zebrafish heart
In:
Nature Communications, vol. 10
DOI: https://doi.org/10.1038/s41467-019-13112-6
Research output: Contribution to Journal › Article (Published) -
Investigating the RAS can be a fishy business: Interdisciplinary opportunities using Zebrafish
In:
Clinical science
DOI: https://doi.org/10.1042/CS20180721
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Pericytes in the renal vasculature roles in health and disease
In:
Nature Reviews Nephrology
DOI: https://doi.org/10.1038/s41581-018-0032-4
Research output: Contribution to Journal › Review article (Published) -
mCCDcl1 cells show Plasticity Consistent with the Ability to Transition between Principal and Intercalated Cells
In:
American Journal of Physiology - Renal Physiology
DOI: https://doi.org/10.1152/ajprenal.00354.2017
Research output: Contribution to Journal › Article (Published) -
The Efficacy of Puromycin and Adriamycin for Induction of Glomerular Failure in Larval Zebrafish Validated by an Assay of Glomerular Permeability Dynamics
In:
Zebrafish
DOI: https://doi.org/10.1089/zeb.2017.1527
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Phenotypic dissection of the mouse Ren-1(d) knockout by complementation with human renin
In:
Journal of Biological Chemistry
DOI: https://doi.org/10.1074/jbc.RA117.000160
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Asymmetric BMP4 signalling improves the realism of kidney organoids
In:
Scientific Reports, vol. 7, pp. 14824
DOI: https://doi.org/10.1038/s41598-017-14809-8
Research output: Contribution to Journal › Article (Published) -
Characterization of triptolide-induced hepatotoxicity by imaging and transcriptomics in a novel zebrafish model
In:
Toxicological Sciences, vol. 159, pp. 380-391
DOI: https://doi.org/10.1093/toxsci/kfx144
Research output: Contribution to Journal › Article (Published) -
Transcription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses
In:
Endocrine connections
DOI: https://doi.org/10.1530/EC-17-0092
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Precise spatio-temporal control of rapid optogenetic cell ablation with mem-KillerRed in Zebrafish
In:
Scientific Reports, vol. 7, pp. 5096
DOI: https://doi.org/10.1038/s41598-017-05028-2
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury
In:
EBioMedicine
DOI: https://doi.org/10.1016/j.ebiom.2017.04.011
Research output: Contribution to Journal › Article (E-pub ahead of print)