I am interested in glucocorticoid signaling and it’s wide-ranging effects particularly on cardiovascular disease risk.
1. Glucocorticoid receptor in the early life programming of cardiac resilience (Current) The heart is one of the first organs in which the glucocorticoid receptor is expressed. The number of heart cells (cardiomyocytes) you have is determined in late development and this is set for life. In this project we explore the role that glucocorticoid signaling has on cardiomyocyte endowment and in the maturation of these heart cells.
2. Glucocorticoid signaling and blood pressure rhythm Molecular clocks exist in just about every cell in the human body; this allows predictive adaptations to our environment of light/dark. Blood pressure also follows a cyclical pattern, being at least 10% higher during the active hours than at rest. An absence of a decrease in resting BP is called non-dipping and is associated with increased cardiovascular risk. Glucocorticoids can evoke non-dipping blood pressure. This project aims to investigate the mechanisms of glucocorticoid-induced non-dipping blood pressure.
I would like to acknowledge the Society for Endocrinology for Summer Studentship funding to investigate “The effect of glucocorticoid signaling on the binucleation and proliferation of cardiomyocytes”. https://www.endocrinology.org
Renal and Blood Pressure Response to a High-Salt Diet in Mice With Reduced Global Expression of the Glucocorticoid Receptor
Glucocorticoids, antenatal corticosteroid therapy and fetal heart maturation
First-in-Man Demonstration of Direct Endothelin-Mediated Natriuresis and Diuresis
Vasopressin regulates extracellular vesicle uptake by kidney collecting duct cells
Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter
Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension
Hypertrophy in the Distal Convoluted Tubule of an 11β-Hydroxysteroid Dehydrogenase Type 2 Knockout Model
Selective endothelin A receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal injury
Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes
Pressure natriuresis and the renal control of arterial blood pressure
Glucocorticoids and renal sodium transport
Quantification of human urinary exosomes by nanoparticle tracking analysis