Jess Ivy
Research Fellow
Address
- Street
-
Queens Medical Research Institute
Edinburgh Bioquarter
47 Little France Crescent - City
- Edinburgh
- Post code
- EH16 4TJ
Research summary
I am interested in glucocorticoid signaling and it’s wide-ranging effects particularly on cardiovascular disease risk.
Projects:
1. Glucocorticoid receptor in the early life programming of cardiac resilience (Current) The heart is one of the first organs in which the glucocorticoid receptor is expressed. The number of heart cells (cardiomyocytes) you have is determined in late development and this is set for life. In this project we explore the role that glucocorticoid signaling has on cardiomyocyte endowment and in the maturation of these heart cells.
2. Glucocorticoid signaling and blood pressure rhythm Molecular clocks exist in just about every cell in the human body; this allows predictive adaptations to our environment of light/dark. Blood pressure also follows a cyclical pattern, being at least 10% higher during the active hours than at rest. An absence of a decrease in resting BP is called non-dipping and is associated with increased cardiovascular risk. Glucocorticoids can evoke non-dipping blood pressure. This project aims to investigate the mechanisms of glucocorticoid-induced non-dipping blood pressure.
I would like to acknowledge the Society for Endocrinology for Summer Studentship funding to investigate “The effect of glucocorticoid signaling on the binucleation and proliferation of cardiomyocytes”. https://www.endocrinology.org
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Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation
In:
JCI Insight
DOI: https://doi.org/10.1172/jci.insight.156437
Research output: Contribution to Journal › Article (Published) -
Endothelin blockade prevents the long-term cardiovascular & renal sequelae of acute kidney injury
In:
Science Translational Medicine
DOI: https://doi.org/10.1126/scitranslmed.abf5074
Research output: Contribution to Journal › Article (Published) -
Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report
In:
Hypertension
Research output: Contribution to Journal › Review article (Published) -
High salt intake activates the hypothalamic-pituitary-adrenal axis, amplifies the stress response, and alters tissue glucocorticoid exposure in mice
In:
Cardiovascular Research
DOI: https://doi.org/10.1093/cvr/cvac160
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Pressure natriuresis induced alterations in renal sodium transporters in diabetic and non-diabetic rats
Research output: Contribution to Conference › Poster (Published) -
Does renal ischaemia/reperfusion injury bite the DUSP3?
In:
Acta Physiologica, vol. 234
DOI: https://doi.org/10.1111/apha.13763
Research output: Contribution to Journal › Editorial (Published) -
Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes
In:
The Journal of Physiology
DOI: https://doi.org/10.1113/JP281860
Research output: Contribution to Journal › Article (Published) -
Abnormal neonatal sodium handling in skin precedes hypertension in the SAME rat
(910 pages)
In:
Pflügers Archiv European Journal of Physiology, pp. 897
DOI: https://doi.org/10.1007/s00424-021-02582-7
Research output: Contribution to Journal › Article (Published) -
Non-dipping Blood Pressure:predictive or reactive renal sodium handling failure
In:
Physiology
DOI: https://doi.org/10.1152/physiol.00024.2020
Research output: Contribution to Journal › Article (Published) -
Activation of the sympathetic nervous system promotes blood pressure salt-sensitivity in C57BL6/J mice
In:
Hypertension
DOI: https://doi.org/10.1161/hypertensionaha.120.16186
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Glucocorticoid receptor activation stimulates the Na-Cl co-transporter and influences the diurnal rhythm of its phosphorylation
In:
American Journal of Physiology - Renal Physiology, vol. 317, pp. F1536-F1548
DOI: https://doi.org/10.1152/ajprenal.00372.2019
Research output: Contribution to Journal › Article (Published) -
Renal and Blood Pressure Response to a High-Salt Diet in Mice With Reduced Global Expression of the Glucocorticoid Receptor
In:
Frontiers in physiology, vol. 9, pp. 848
DOI: https://doi.org/10.3389/fphys.2018.00848
Research output: Contribution to Journal › Article (Published) -
Glucocorticoids, antenatal corticosteroid therapy and fetal heart maturation
In:
Journal of molecular endocrinology, vol. 61, pp. R61-R73
DOI: https://doi.org/10.1530/JME-18-0077
Research output: Contribution to Journal › Review article (Published) -
First-in-Man Demonstration of Direct Endothelin-Mediated Natriuresis and Diuresis
In:
Hypertension
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.116.08832
Research output: Contribution to Journal › Article (Published) -
Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells
In:
Journal of the American Society of Nephrology, vol. 27, pp. 3345-3355
DOI: https://doi.org/10.1681/ASN.2015050568
Research output: Contribution to Journal › Article (Published) -
Glucocorticoids Induce Nondipping Blood Pressure by Activating the Thiazide-Sensitive Cotransporter
In:
Hypertension, vol. 67, pp. 1029–1037
DOI: https://doi.org/10.1161/HYPERTENSIONAHA.115.06977
Research output: Contribution to Journal › Article (Published) -
Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension
(11 pages)
In:
Circulation, vol. 133, pp. 1360-1370
DOI: https://doi.org/10.1161/CIRCULATIONAHA.115.019341
Research output: Contribution to Journal › Article (Published) -
Hypertrophy in the Distal Convoluted Tubule of an 11β-Hydroxysteroid Dehydrogenase Type 2 Knockout Model
In:
Journal of the American Society of Nephrology, vol. 26, pp. 1537-1548
DOI: https://doi.org/10.1681/ASN.2013060634
Research output: Contribution to Journal › Article (Published) -
Selective endothelin A receptor antagonism with sitaxentan reduces neointimal lesion size in a mouse model of intraluminal injury
(11 pages)
In:
British Journal of Pharmacology, vol. 172, pp. 2827-2837
DOI: https://doi.org/10.1111/bph.13086
Research output: Contribution to Journal › Article (Published) -
Klf15 Is Critical for the Development and Differentiation of Drosophila Nephrocytes
In:
PLoS ONE, vol. 10
DOI: https://doi.org/10.1371/journal.pone.0134620
Research output: Contribution to Journal › Article (Published)