Professor Jayne Hope
Personal Chair of Immunology
Contact details
Address
- Street
-
The Roslin Institute
Easter Bush Campus
Midlothian - City
- Post code
- EH25 9RG
Availability
Willingness to take Ph.D. students: Yes
Background
Dr Hope obtained a BSc (Hons) degree in Biological Sciences (Microbiology) from the University of Birmingham in 1991, and a PhD degree from the University of Manchester in 1994. She then carried out postdoctoral research at the University of Manchester (1994-1996) and Kings College School of Medicine and Dentistry (1996-1997). Between 1997 and 2011 Dr Hope was employed at the Institute for Animal Health where her research focused on research into innate and adaptive immune mechanisms in cattle specifically in relation into bovine tuberculosis. Dr Hope joined The Roslin Institute in August 2011; her research group focusses on innate immune responses to Mycoabcteria and other bovine pathogens.
Qualifications
1994 Doctor of Philosophy (PhD), University of Manchester Cytokine Regulation of Primary Contact Sensitisation
1991 Bachelor of Science, University of Birmingham
Responsibilities & affiliations
British Society for Immunology Forum Regional Representative for Scotland
Editorial Board Member for Veterinary Immunology & Immunopathology
Associate Editor (immunology) for Veterinary Research
Member of British Society for Immunology Vaccine Affinity Group
Research summary
Immune responses to Mycobacterial infections in cattle.
Current research interests
The group focuses on cellular immune responses aiming to define the mechanisms whereby natural immunity is achieved and how protective immunity is induced by vaccination. We focus specifically on antigen presenting cells and their interactions with other cells of the innate immune system including natural killer cells and gamma delta TCR+ T lymphocytes. The overall aim is to define the functional and phenotypic characteristics of innate immune cells and to assess their role in protective immunity to mycobacterial pathogens including Mycobacterium bovis and M. avium paratuberculosis. These pathogens cause economically important diseases in cattle: bovine tuberculosis and Johne’s disease. Alongside this we are interested in defining host-pathogen interactions in feline tuberculosis. Effective control of mycobacterial diseases requires the development of effective vaccines and/or diagnostic tests: this requires detailed knowledge of protective immune mechanisms. The development of new immunological tools, reagents and assays and validation across species is also an important area of research. This will provide the capacity to determine immunological correlates of protection against a number of strategically important diseases. Research Groups Liz Glass group Liam Morrison group Ivan Morrison group Gary Entrican group (Moredun Research Institute) John Hammond group (The Pirbright Institute) Research students Current Students: Emily Anderson PhD Student 2016-2022 (part-time) Conor O'Halloran PhD Student 2015-2019 (second supervisor) Lindsey Waddell PhD Student 2014-2020 (part time) Laura Vezza PhD Student 2014-2018 (second supervisor) Heather Mathie PhD Student 2013-2017 Rebecca Mclean PhD Student 2013-2017 (second supervisor) Previous Students: Carly Hamilton PhD Student 2011-2015 Nazneen Siddiqui PhD Student 2007-2011 Sally Price PhD Student 2006-2009 Andrew McCormick PhD Student 2004-2007-
Protective Efficacy of BCG Vaccination in Calves Vaccinated at Different Ages
In:
Pathogens
Research output: Contribution to Journal › Article (Accepted/In press) -
Development of an enzyme-linked immunosorbent assay for the diagnosis of feline tuberculosis
(7 pages)
In:
Veterinary Immunology and Immunopathology, vol. 255, pp. 1-7
DOI: https://doi.org/10.1016/j.vetimm.2022.110538
Research output: Contribution to Journal › Article (E-pub ahead of print) -
The immune response to lumpy skin disease virus in cattle is influenced by inoculation route
(21 pages)
In:
Frontiers in Immunology, vol. 13, pp. 1-21
DOI: https://doi.org/10.3389/fimmu.2022.1051008
Research output: Contribution to Journal › Article (Published) -
γδ TCRs Function as Innate-like Receptors in the Bovine γδ T Cell Response against Leptospira
(10 pages)
In:
The Journal of Immunology, vol. 209, pp. 1870-1879
DOI: https://doi.org/10.4049/jimmunol.2200319
Research output: Contribution to Journal › Article (Published) -
Ocular mycobacterial lesions in cats
(14 pages)
In:
Veterinary Pathology, vol. 59, pp. 792-805
DOI: https://doi.org/10.1177/03009858221098431
Research output: Contribution to Journal › Article (Published) -
The Development of 3D Bovine Intestinal Organoid Derived Models to Investigate Mycobacterium Avium ssp Paratuberculosis Pathogenesis
In:
Frontiers in Veterinary Science, vol. 9
DOI: https://doi.org/10.3389/fvets.2022.921160
Research output: Contribution to Journal › Article (Published) -
Protein Levels of Pro-inflammatory Cytokines and Chemokines as Biomarkers of Mycobacterium bovis Infection and BCG Vaccination in Cattle
In:
Pathogens, vol. 11, pp. 1-16
DOI: https://doi.org/10.3390/pathogens11070738
Research output: Contribution to Journal › Article (Published) -
Establishment of Bovine 3D Enteroid-derived 2D monolayers
(13 pages)
In:
Veterinary Research, vol. 53
DOI: https://doi.org/10.1186/s13567-022-01033-0
Research output: Contribution to Journal › Article (Published) -
Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactions
(14 pages)
In:
BMC Biology, vol. 20
DOI: https://doi.org/10.1186/s12915-021-01217-8
Research output: Contribution to Journal › Article (Published) -
Stem cell-derived macrophages as a new platform for studying host-pathogen interactions in livestock
DOI: https://doi.org/10.1101/2021.09.10.459580
Research output: › Working paper (Published)