Professor Javier Caceres
Group Leader
- MRC Human Genetics Unit
- Institute of Genetics and Cancer
Contact details
- Email: javier.caceres@ed.ac.uk
Background
Dr. Caceres is a Principal Investigator at the MRC Human Genetics Unit (MRC HGU, Edinburgh) and a Professor at the School of Molecular & Clinical Medicine, University of Edinburgh. He holds a Personal Chair in RNA and Gene Expression. He studied for a B.Sc. and a Ph.D. in Molecular Biology both at the University of Buenos Aires in Argentina. In 1989, he moved to the USA to carry out postdoctoral research in the laboratory of Jim Dahlberg (University of Wisconsin-Madison), where he studied transcriptional control of small nuclear RNA genes. In 1991, he joined Adrian Krainer’s laboratory at Cold Spring Harbor, where he worked on alternative splicing regulation. He joined the MRC Human Genetics Unit in 1997. His laboratory is interested on the regulation of gene expression. Their focus is on the role of RNA-binding proteins (RNABPs) in gene expression and how alterations to RNA processing mechanisms can contribute to human disease. He serves in numerous International reviewing panels and Editorial Boards. He was elected as a member of the European Molecular Biology Organization (EMBO) in 2008 and as a fellow of the Royal Society of Edinburgh in 2011.
Qualifications
-
Master
- 1985, Master in Science, University of Buenos Aires, Argentina
- Doctorate
- 1989, Doctor of Science, University of Buenos Aires, Argentina
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Genetic variation and RNA structure regulate microRNA biogenesis
(12 pages)
In:
Nature Communications, vol. 8
DOI: https://doi.org/10.1038/ncomms15114
Research output: Contribution to Journal › Article (Published) -
A slow transcription rate causes embryonic lethality and perturbs kinetic coupling of neuronal genes
(18 pages)
In:
EMBO Journal, vol. 38
DOI: https://doi.org/10.15252/embj.2018101244
Research output: Contribution to Journal › Article (Published) -
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants
In:
Nature Communications
DOI: https://doi.org/10.1038/s41467-020-14829-5
Research output: Contribution to Journal › Article (Published) -
Identification of a localized Nonsense-Mediated Decay pathway at the Endoplasmic Reticulum
In:
Genes and Development, vol. 34, pp. 1075-1088
DOI: https://doi.org/10.1101/gad.338061.120
Research output: Contribution to Journal › Article (E-pub ahead of print) -
Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function
In:
eLIFE
DOI: https://doi.org/10.7554/eLife.65104
Research output: Contribution to Journal › Article (Published)