Filip Margetiny
Thesis title: Molecular mechanisms of neuromuscular paralysis caused by agricultural insecticide metabolites
PhD Precision Medicine with Integrated Study
Year of study: 2
- Centre for Discovery Brain Sciences
- Usher Institute of Population Health Sciences and Informatics
Contact details
- Email: fmargeti@ed.ac.uk
PhD supervisors:
Address
- Street
-
1 George Square
- City
- Edinburgh
- Post code
- EH8 9JZ
Background
As a PhD student on the Precision Medicine DTP in Centre for Discovery Brain Sciences, my project is concerned with construction of biophysical models of neuromuscular synaptic transmission and cellular signalling to characterise solvent and organophosphorus toxicity at neuromuscular junction. My work includes machine learning, stochastic modelling and in-vitro electrophysiology in HEK and CN-21 cells (outside-out patch, whole cell patch), as well as molecular modelling of drug binding.
Qualifications
BSc (Hons) Biomedical Sciences with Management (Pharmacology), University of Edinburgh
Undergraduate teaching
Demonstrator/Tutor: Biomedical Sciences 2, Chemical Pharmacology 2, Pharmacology 3, Applied Pharmacology 3
Research summary
Neuromuscular junction, single channel electrophysiology, neuromuscular toxicology, machine learning
Current research interests
Cellular neuroscience, neuropharmacology, organophosphate toxicology, solvent toxicology, stochastic modelling, kinetic modelling, molecular modellingPast research interests
Computer vision, calcium imaging, ex-vivo tissue cultureAffiliated research centres
Project activity
Currently I'm working on modelling toxic activity of solvents in the context of organophosphate poisoning and IMS, and on developing routines for analysis of single channel and whole cell recording data. My previous work included work on organophosphate toxicology in mice and tissue culture, kinetic modelling of NMDA receptors and investigation of Drosophila neuromuscular transmission.
Current project grants
MRC DTP Precision Medicine