Vahid Aslanzadeh (PhD)

Postdoctoral Research Fellow

Current research interests

Insulin acts by binding the transmembrane insulin receptor, triggering biochemical responses within target cells. Insulin resistance denotes reduced ability of insulin to lower blood glucose, and is associated with several major diseases. Some extreme forms of insulin resistance are caused by genetic mutations in the gene that encodes the receptor, INSR. The most severe of these disorders leads to uncontrollable diabetes and death in infancy, but many different mutations are found across the large receptor protein, and very few have been studied biochemically. My research is using genomics and cell biology to interrogate the effect of mutations in the insulin binding domain on receptor expression, insulin binding and receptor signalling. Findings will make a valuable resource for the clinical community and will be of immediate translational value diagnostically. It will also inform future experimental medicine studies, and rapid identification of mutations potentially amenable to novel targeted therapies bypassing the signalling defect.