Vahid Aslanzadeh (PhD)
Postdoctoral Research Fellow

Current research interests
Insulin acts by binding the transmembrane insulin receptor, triggering biochemical responses within target cells. Insulin resistance denotes reduced ability of insulin to lower blood glucose, and is associated with several major diseases. Some extreme forms of insulin resistance are caused by genetic mutations in the gene that encodes the receptor, INSR. The most severe of these disorders leads to uncontrollable diabetes and death in infancy, but many different mutations are found across the large receptor protein, and very few have been studied biochemically. My research is using genomics and cell biology to interrogate the effect of mutations in the insulin binding domain on receptor expression, insulin binding and receptor signalling. Findings will make a valuable resource for the clinical community and will be of immediate translational value diagnostically. It will also inform future experimental medicine studies, and rapid identification of mutations potentially amenable to novel targeted therapies bypassing the signalling defect.-
A fast and tuneable auxin-inducible degron for depletion of target proteins in budding yeast
(7 pages)
In:
Yeast, vol. 36, pp. 75-81
DOI: https://doi.org/10.1002/yea.3362
Research output: Contribution to Journal › Article (Published) -
Revisiting the window of opportunity for co-transcriptional splicing efficiency and fidelity
(14 pages)
DOI: https://doi.org/10.1101/497040
Research output: › Preprint (Published) -
Transcription rate strongly affects splicing fidelity and cotranscriptionality in budding yeast
(11 pages)
In:
Genome Research, vol. 28, pp. 203-213
DOI: https://doi.org/10.1101/gr.225615.117
Research output: Contribution to Journal › Article (Published) -
Molecular characterization of a patient presumed to have prader-willi syndrome.
In:
Clinical Medicine Insights: Case Reports
DOI: https://doi.org/10.4137/CCRep.S11510
Research output: Contribution to Journal › Article (Published) -
Global profiling of alternative splicing events and gene expression regulated by hnRNPH/F.
In:
PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0051266
Research output: Contribution to Journal › Article (Published) -
Homology Modeling and Functional Characterization of PR-1a Protein of Hordeum vulgare subsp. Vulgare.
In:
Bioinformation
DOI: https://doi.org/10.6026/97320630008807
Research output: Contribution to Journal › Article (Published)