Dr Úna Clancy (MB BAO BCh PhD)

Scottish Clinical Research Excellence Development Scheme (SCREDS) Clinical Lecturer

Biography

Background

  • Current Scottish Clinical Research Excellence Development Scheme (SCREDS) Clinical Lecturer
  • Previous Chief Scientist Office Clinical Academic Fellow
  • Previous Princess Margaret Research Development Fellow
  • Recipient of SINAPSE Postgraduate and Early Career Research Experience travel fellowship to Sunnybrook Dementia Institute, University of Toronto

Qualifications

MB BAO BCh

MRCPUK (Edin)

Undergraduate teaching

Supervisor, BMS Honours Student Projects

Postgraduate teaching

Department of Geriatric Medicine tutor at the University of Edinburgh, August 2022-present

Research summary

Analysing relationships between neuropsychiatric symptoms and longitudinal imaging features of cerebral small vessel disease

Current research interests

Clinical features of SVD progression Delirium and cerebral small vessel disease Neuropsychiatric symptoms and cerebral small vessel disease Gait and SVD

Knowledge exchange

Publications

Clancy U*, Makin SDJ, McHutchison CA, Cvoro V, Chappell FM, Valdes Hernandez MC, Sakka E, Doubal F, Wardlaw JM Impact of small vessel disease progression on long-term cognitive and functional changes after stroke. Neurology Apr 2022, 98 (14) e1459-e1469

Clancy U*, Ramirez J, Chappell FM, Doubal FN, Wardlaw JM, Black SE Small vessel disease progression and neuropsychiatric symptoms in Alzheimer’s and vascular cognitive impairment. Cerebral Circulation: Cognition and Behavior, Volume 3, 2022, 100041

Clancy U,* Appleton JP, Arteaga C, Doubal FN, Bath PM, Wardlaw JM. Clinical management of cerebral small vessel disease: a call for a holistic approach. Chin Med J (Engl). 2020 Oct 6; ;134(2):127-142 Jiménez-Sánchez L, Hamilton OKL, Clancy U*, Backhouse EV, Stewart CR, Stringer MS, Doubal FN, Wardlaw JM Sex differences in cerebral small vessel disease: a systematic review and meta-analysis. Front Neurol. 2021 Oct 28;12:756887

Zhang JF, Lim HF, Chappell FM, Clancy U*, Wiseman S, Valdés-Hernández MC, Garcia DJ, Bastin ME, Doubal FN, Hewins W, Cox SR, Maniega SM, Thrippleton M, Stringer M, Jardine C, McIntyre D, Barclay G, Hamilton I, Kesseler L, Murphy M, Perri CD, Wu YC, Wardlaw JM. Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease. Neurobiol Aging. 2021 Oct;106:130-138

Manning C, Stringer M, Dickie B, Clancy U*, Valdés Hernandez MC, Wiseman SJ, Garcia DJ, Sakka E, Backes WH, Ingrisch M, Chappell F, Doubal F, Buckley C, Parkes LM, Parker GJM, Marshall I, Wardlaw JM, Thrippleton MJ. Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage. Magn Reson Med. 2021 Oct;86(4):1888-1903

Clancy U*, Gilmartin D, Jochems ACC, Knox L, Doubal FN, Wardlaw JM. Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis. The Lancet Psychiatry. 2021 Mar;8(3):225-236

Clancy U*, Garcia DJ, Stringer MS, Thrippleton MJ, Valdés-Hernández MC, Wiseman S, Hamilton OK, Chappell FM; Brown R, Blair GW, Hewins W, Sleight E, Ballerini L, Bastin ME, Muñoz Maniega, S; MacGillivray T, Hetherington K, Hamid C, Arteaga C, Morgan AG, Manning C, Backhouse E, Hamilton I, Job D, Marshall I, Doubal FN and Wardlaw JM. Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3. Eur Stroke J. 2021 Mar;6(1):81-88

Jochems ACC, Blair GW, Stringer MS, Thrippleton MJ, Clancy U*, Chappell FM, Brown R, Garcia DJ, Hamilton OKL, Morgan AG, Marshall I, Hetherington K, Wiseman S, MacGillivray T, Valdés Hernandez MC, Doubal FN, Wardlaw JM. Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases. Stroke. 2020;51(5):1503-1506

Clancy U*, Brown M, Alio Z, Wardle K, Pendleton N. Older people with hip fracture transferred to intermediate care: outcomes in an integrated health and social care model. Future Healthc J. 2018 Feb;5(1):58-63

Clancy U*, Ronayne A, Prentice MB, Jackson A. Actinomyces meyeri brain abscess following dental extraction BMJ Case Reports 2015 Apr 13;2015:bcr2014207548

Clancy U*, Tuthill A, Moran J. Prevalence and predictors of influenza and pneumococcal vaccine uptake in patients with diabetes mellitus. Ir Med J. 2012 Oct;105(9):298-300

Li BM, Castorina LV, Valdés Hernández MC, Clancy U*, Wiseman SJ, Sakka E, Storkey AJ, Jaime Garcia D, Cheng Y, Doubal FN, Thrippleton MT, Stringer MS, Wardlaw JM. Deep Attention Super-Resolution of Brain Magnetic Resonance Images Acquired Under Clinical Protocols. Frontiers in Computational Neuroscience (in press: Manuscript ID 887633)

Wiseman S, Zhang JF, Gray C, Hamid C, Valdes Hernandez MC, Ballerini L, Thrippleton M, Manning C, Stringer M, Sleight E, Munoz Maniega S, Morgan A, Cheng Y, Arteaga C, Jaime Garcia D, Clancy U*, Doubal F, Dhillon B, MacGillivray T, Wu YC, Wardlaw JM. Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease. Journal of Cerebral Blood Flow and Metabolism (in press: Manuscript ID JCBFM-0178-22-ORIG.R1)

Jochems ACC, Muñoz Maniega S, Clancy U*, Jaime Garcia D, Arteaga C, Hewins W, Penman R, Hamilton OKL, Czechoń A, Backhouse EV, Thrippleton MJ, Stringer MS, Bastin ME, Valdés Hernández MC, Wiseman S, Chappell FM, Doubal FN, Wardlaw JM. Associations of peak-width skeletonized mean diffusivity and post-stroke cognition. Life (in press)

Project activity

During my CSO fellowship, I led coordination and recruitment of a prospective serial imaging study of stroke patients (>180 patients/500 visits/2.5 years) achieving 90% one-year retention, 2018-2021. I led the study team and chaired weekly study team meetings. I contributed to study administration including set-up, ethical and R&D approvals, and progress and funding reports. I also recruited to 4 multicentre studies including the LACI-2 RCT., Rates Risks and Routes to Reduce Vascular Dementia, the LACunar Intervention (LACI-2) Trial-2, TREAT-SVDs trial, and the INVESTIGATE-SVDs study.

Current project grants

Awarding body: British Geriatrics Society Research Start Up Grant
Grantholders: Clancy U, Doubal FN, Maclullich A, Wardlaw JM
Title: Studies of Small Vessel Diseases: Brain Imaging in Delirium
Award amount: £10,000
Role: Lead Applicant/Principal Investigator
Dates: August 2022 - August 2023

Past project grants

Awarding body: Stroke Association Project Grant
Grantholders: Doubal FN, Clancy U, Chappell F, Wiseman S, Wardlaw JM
Title: Small Vessel Disease - Spotlight on Symptoms (SVD-SOS): Improving recognition of symptoms and signs of
progressing cerebral small vessel disease-related brain damage to prevent cognitive decline, dementia and stroke (SA PG
19\100068)
Role: co-applicant, study recruitment and coordination
Dates: 2019-2022

Awarding body: Chief Scientist Office Clinical Academic Fellowship
Grantholder: Clancy U
Title: Symptoms of SVD: identifying non-traditional neurological and cognitive symptoms of cerebral small vessel disease
(CAF/18/08)
Award amount: £221,372
Role: Clinical Research Fellow
Dates: 2018-2021

Awarding body: Stroke Association
Grantholder: Clancy U, Whiteley W
Title: Princess Margaret Research Development Fellowship
Award amount: £20,652
Role: Clinical Research Fellow - Salary support to work on pilot data and develop a successful training fellowship application
Dates: February 2018 - August 2018

Awarding body: Scottish Imaging Network – A Platform for Scientific Excellence Postdoctoral and Early Career Exchange
Travel Grant.
Title: Neuropsychiatric symptoms as a sign of small vessel disease progression in cognitive impairment
Award amount: £3,800
Role: Visit to collaborators at Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, to harmonise multisite study procedures and analyse longitudinal data
Dates: 2018-2019

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