Dr Peter Connick
Senior Clinical Research Fellow
- Centre for Clinical Brain Sciences
- Euan MacDonald Centre for Motor Neurone Disease Research
- Anne Rowling Regenerative Neurology Clinic
Contact details
- Email: pconnick@exseed.ed.ac.uk
Background
I'm an academic neurologist who trained in Cambridge and London before taking my current position at the University of Edinburgh, Anne Rowling Regenerative Neurology Clinic.
Qualifications
Doctor of Philosophy (PhD), University of Cambridge:Autologous mesenchymal stem cells as a neuroprotective therapy for secondary progressive multiple sclerosis
Bachelor of Medicine and Bachelor of Surgery, University of Glasgow
Bachelor of Science, University of Glasgow
Research summary
The big challenge in 21st century neurology is to develop treatments that can slow, stop, or reverse the loss of brain cells in neurodegenerative diseases like the dementias, motor neurone disease, and MS.
Part of the reason why we don't already have these treatments is because we lack the tools to measure neuroprotection and brain repair in clinical trials. My work aims to develop the measurement tools we need.
Separately, by defining diseases through their symptoms rather than through the underlying (patho)biology, most patients in any regenerative neurology trial will have little prospect of benefit. I also work on methods to ""stratify" neurodegenerative diseases so that the right person gets the right treatment at the right time.
Research Interests
Regenerative neurology spanning two principal themes. First: developing and improving existing techniques to measure the impact of regenerative therapies in brain diseases, and second: developing techniques to stratify phenomenologically defined patient groups according to the undelying pathology - i.e. stratified medicine in the neurodegenerative disorders.
Related links
Research into neurodegenerative conditions at the Centre for Clinical Brain Sciences
Clinical research & trials at the Centre for Clinical Brain Sciences
-
Psychometric properties of the PHQ-9 depression scale in people with multiple sclerosis: A systematic review
In:
PLoS ONE, vol. 14, no. 2, pp. e0197943
DOI: https://doi.org/10.1371/journal.pone.0197943
Contribution to journal › Article (Published) -
Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial (MS-SMART). : A multi-arm phase 2b randomised, double blind, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis.
In:
BMJ Open
DOI: https://doi.org/10.1136/bmjopen-2018-021944
Contribution to journal › Article (Published) -
Characterisation of tissue-type metabolic content in Secondary Progressive Multiple Sclerosis: a Magnetic Resonance Spectroscopic Imaging study
In:
Journal of Neurology
DOI: https://doi.org/10.1007/s00415-018-8903-y
Contribution to journal › Article (E-pub ahead of print) -
MS-SMART Trial : a multi-arm phase 2b randomised, double blind, parallel group, placebo-controlled clinical trial comparing the efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis [NCT01910259]
(2 pages)
In:
Multiple Sclerosis, vol. 24, pp. 986-987
Contribution to journal › Meeting abstract (Published) -
The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: a systematic review and meta-analysis.
In:
PLoS ONE
DOI: https://doi.org/10.1371/journal.pone.0177727
Contribution to journal › Article (E-pub ahead of print)